A5077104686- Glycosylation and Glycoproteins Research
- Genomics and Phylogenetic Studies
- Machine Learning in Bioinformatics
- Enzyme Structure and Function
- Protein Structure and Dynamics
- interferon and immune responses
- Insect Utilization and Effects
- Forensic Entomology and Diptera Studies
- Infrared Thermography in Medicine
- Milk Quality and Mastitis in Dairy Cows
- Immunotherapy and Immune Responses
- Neuropeptides and Animal Physiology
- Pesticide and Herbicide Environmental Studies
- Parasites and Host Interactions
- Crystallization and Solubility Studies
- vaccines and immunoinformatics approaches
- Parasite Biology and Host Interactions
- Electrochemical sensors and biosensors
- Chemical Synthesis and Analysis
- Insect behavior and control techniques
- melanin and skin pigmentation
- Helminth infection and control
- Receptor Mechanisms and Signaling
- Animal Virus Infections Studies
- Microbial Natural Products and Biosynthesis
Tamil Nadu Veterinary and Animal Sciences University
2020-2024
Central Sheep and Wool Research Institute
2023
Solamalai College of Engineering
2020
Madurai Kamaraj University
2011-2015
National Centre for Biological Sciences
2008-2009
Manipal Academy of Higher Education
2008
Indian Institute of Science Bangalore
2006
Mastitis, a prevalent inflammatory condition in the mammary gland of dairy cattle, is primarily caused by bacterial infections and results reduced milk production quality. There are two main types mastitis: clinical subclinical. Clinical mastitis visible through symptoms such as swelling, redness, abnormal secretion, while subclinical lacks signs but still impacts The economic health cattle profound, leading to yield, increased veterinary costs, potential culling affected animals,...
The effect of N-terminal diproline segments in nucleating helical folding designed peptides has been studied two model sequences Piv-Pro-Pro-Aib-Leu-Aib-Phe-OMe (1) and Boc-Aib-Pro-Pro-Aib-Val-Ala-Phe-OMe (2). structure 1 crystals, determined by X-ray diffraction, reveals a (αR) conformation for the segment residues 2 to 5, stabilized one 4→1 hydrogen bond 5→1 interactions. N-terminus residue, Pro(1) adopts polyproline II (PII) conformation. NMR studies three different solvent systems...
The serotonergic system has been implicated in emotional and cognitive function. In particular, 5-HT2A (5-hydroxytrytamine receptor 2A) is attributed to a number of disorders like schizophrenia, depression, eating anxiety. 5-HT2A, being GPCR (G-protein coupled receptor), important the pharmaceutical industry as proven target for these disorders. Despite their extensive clinical importance, structural studies this protein lacking due difficulties determining its crystal structure.
Accurate sequence alignments are crucial for modelling and to provide an evolutionary picture of related proteins. It is well-known that hard obtain during distant relationships. Three thousand fifty-two 218 pairs protein domain structural entries, with <40% identity, belonging different classes, diverse sizes length-rigid/variable domains were performed using 12 programs. Structural parameters such as root mean square deviation, secondary-structural content equivalences considered critical...
A detailed comparison of protein domains that belong to families and superfamilies shows structure is better conserved than sequence during evolutionary divergence. Sequence alignments, guided by structural features, permit a sampling the space effective construction libraries for fold recognition. alignments are useful models in defining structure-function relationships superfamilies. The PASS2 database, maintained authors, presents proteins related at superfamily level characterised low...
Interleukin-8 and related chemokines are small proteins that bind to receptors belonging the large family of G-protein-coupled receptors. They can cause migration cells like neutrophils eosinophils some them implicated in angiogenic diseases. More than 40 subfamilies these ligands known share poor sequence similarity display receptor specificity. There is very little structural information about mode binding between We have employed multi-fold sensitive search methods provide a repertoire...
Interferon (IFN) epsilon (ε) has been identified as an important protein of interest, which plays a major role in innate immune system mammals. Indian Avishaan sheep is well known for its twinning and triplet traits. Hence, the present study undertaken with aim to characterize IFNε, although reports found on Ovis aries IFN-epsilon Arabian Camel IFN-epsilon. The cDNA type I interferon viz., Interferon-ε from liver amplified by PCR subsequently cloned sequence analysis. Sequence analysis...
Interleukin-17A is a pro-inflammatory cytokine that plays key role in the immune response to many pathogens and implicated autoimmune diseases. This molecule also involved providing protection bacterial fungal infections of gastro-intestinal tract respiratory mucosa. Although molecular aspect IL-17A has been studied few species, no data are available for buffalo, which one major sources milk production India. Therefore, present study, gene Indian Murrah Buffalo origin was cloned, expressed,...
Among the various groups of pesticides that are being used world over, p-Nitro phenyl (pNP)-substituent Organophosphates (OPs) acutely toxic and more extensively group pesticides. Organophosphorus hydrolase (OPH) is an enzyme involved in hydrolysis aromatic OPs Thus, OPH extremely attractive biological component biosensors for detection pNP substituent concentration. The difference structural organisation from different microbe will influences catalytic activity these enzymes. So, rationale...
Abstract Purpose Upon post mortem examination of sheep (from SRRC, Mannavanur, South India) having the history natural death, nasal sinuses animals contained dipteran larvae. The objective present study is to characterize larvae species infesting being maintained at by means COI gene based PCR. Methods During last week May 2021, an Avikalin male (20 months old) died suddenly. Post examination, skull dead was in sinuses. were washed PBS (pH 7.2) and preserved 70 % alcohol. taken out alcohol...