A5054528582- Neurofibromatosis and Schwannoma Cases
- Bone Tumor Diagnosis and Treatments
- Meningioma and schwannoma management
- Asthma and respiratory diseases
- Soft tissue tumor case studies
- Pelvic floor disorders treatments
- Smoking Behavior and Cessation
- Urinary Bladder and Prostate Research
- Sarcoma Diagnosis and Treatment
- Urinary Tract Infections Management
- Mitochondrial Function and Pathology
- Plant biochemistry and biosynthesis
- Respiratory and Cough-Related Research
- Photosynthetic Processes and Mechanisms
- Neuroblastoma Research and Treatments
Dr. Kade Pharmazeutische Fabrik (Germany)
2021
Pfizer (Germany)
2012
Klinikum Kassel
2012
Universität Ulm
2002-2007
Abstract Branched-chain amino acid transaminases (BCATs) play a crucial role in the metabolism of leucine, isoleucine, and valine. They catalyze last step synthesis and/or initial degradation this class acids. In Arabidopsis, seven putative BCAT genes are identified by their similarity to counterparts from other organisms. We have now cloned respective cDNA sequences six these genes. The deduced show between 47.5% 84.1% identity each about 30% homologous enzymes yeast (Saccharomyces...
The NF2 gene encodes the tumour suppressor protein merlin. mutation of a single allele this causes autosomal dominantly inherited disease neurofibromatosis type 2 (NF2), which is characterized mainly by vestibular schwannoma carrying second hit mutation. Complete lack merlin also found in spontaneous schwannomas and meningiomas. As events leading to development are largely unknown we investigated differences expression between cells from patients normal human primary Schwann cDNA array...
Neurofibromatosis 2 (NF2) is a hereditary tumor disease characterized by bilateral vestibular schwannomas. Polyneuropathy seems to occur quite frequently in NF2 and most cases, the etiology of this neuropathy unclear, especially when symmetric. believed follow two‐hit hypothesis. According this, one allele mutated germline, second hit somatic results formation. The loss locus, often entire chromosome 22. We set out investigate underlying genetics peripheral nerve patients with...
<b><i>Aims:</i></b> Although varenicline is commonly prescribed in primary care, information on smoking-related comorbidities and the effectiveness of this context Germany scarce. This study assessed efficacy safety a large sample patients seeking smoking cessation treatment through their general practitioners. The frequency was also evaluated. <b><i>Methods:</i></b> 12-week, prospective, observational, non-comparative phase IV trial conducted...
Abstract Purpose The main objective of this open, prospective, multicentre, observational study is to investigate the relapse rate and tolerability lactic acid gels in adult female patients with recurrent urinary tract infections during routine practice. Methods Data were collected from undergoing intermittent short courses intravaginal treatment gel for prevention infections. observation period individual was 4 months, aimed at covering four treatment. on UTI relapses, tolerability,...
Neurofibromatose Typ 2 (NF2) ist eine seltene (1:40000 Geburte) autosomal dominant vererbte Tumorerkrankung klinisch charakterisiert durch die Entstehung multiple ZNS Tumoren, vor allem Schwannome, Meningiome und Ependymome. Pathognomonisch sind bilaterale N. vestibularis Schwannome. NF2 Patienten tragen Mutationen auf einem Allel des Gens (Chromosom 22), das für ERM (Ezrin, Radixin, Moesin) Protein Merlin kodiert. Durch einen „second hit“ kommt es zu Verlust der Merlinexpression...