A5007370162- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Microbial Metabolism and Applications
- Autoimmune and Inflammatory Disorders
- Aquaculture disease management and microbiota
- Immune responses and vaccinations
- Atherosclerosis and Cardiovascular Diseases
- Bacterial biofilms and quorum sensing
- Ocular Surface and Contact Lens
- melanin and skin pigmentation
- Cell Adhesion Molecules Research
- Olfactory and Sensory Function Studies
- Gut microbiota and health
- Corneal Surgery and Treatments
- Fungal Biology and Applications
- Chemokine receptors and signaling
Duke University
2023-2024
Abstract Granulomas often form around pathogens that cause chronic infections. Here, we discover an innate granuloma model in mice with environmental bacterium called Chromobacterium violaceum . Granuloma formation not only successfully walls off, but also clears, the infection. The infected lesion can arise from a single replicates despite presence of neutrophil swarm. Bacterial replication ceases when macrophages organize infection and granuloma. This response is accomplished independently...
Granulomas are defined by the presence of organized layers immune cells that include macrophages. often characterized as a way for system to contain an infection and prevent its dissemination. We recently established mouse model where Chromobacterium violaceum induces innate form granulomas in liver. This response successfully eradicates bacteria returns liver homeostasis. Here, we sought characterize chemokines involved directing distinct granuloma. use spatial transcriptomics investigate...
Granulomas are defined by the presence of organized layers immune cells that include macrophages. often characterized as a way for system to contain an infection and prevent its dissemination. We recently established mouse model where Chromobacterium violaceum induces innate form granulomas in liver. This response successfully eradicates bacteria returns liver homeostasis. Here, we sought characterize chemokines involved directing distinct granuloma. use spatial transcriptomics investigate...
Abstract Granulomas are defined by the presence of organized layers immune cells that include macrophages. often characterized as a way for system to contain an infection and prevent its dissemination. We recently established mouse model where Chromobacterium violaceum induces innate form granulomas in liver. This response successfully eradicates bacteria returns liver homeostasis. Here, we sought characterize chemokines involved directing distinct granuloma. use spatial transcriptomics...
Granulomas often form around pathogens that cause chronic infections. Here, we discover a novel granuloma model in mice.
Granulomas are defined by the presence of organized layers immune cells that include macrophages. often characterized as a way for system to contain an infection and prevent its dissemination. We recently established mouse model where Chromobacterium violaceum induces innate form granulomas in liver. This response successfully eradicates bacteria returns liver homeostasis. Here, we sought characterize chemokines involved directing distinct granuloma. use spatial transcriptomics investigate...
Granulomas are defined by the presence of organized layers immune cells that include macrophages. often characterized as a way for system to contain an infection and prevent its dissemination. We recently established mouse model where Chromobacterium violaceum induces innate form granulomas in liver. This response successfully eradicates bacteria returns liver homeostasis. Here, we sought characterize chemokines involved directing distinct granuloma. use spatial transcriptomics investigate...