A5072896488- Nanoparticles: synthesis and applications
- Nanoparticle-Based Drug Delivery
- Advanced Nanomaterials in Catalysis
- Anesthesia and Pain Management
- Carcinogens and Genotoxicity Assessment
- Graphene and Nanomaterials Applications
- Genomics, phytochemicals, and oxidative stress
- Toxic Organic Pollutants Impact
- Retinoids in leukemia and cellular processes
- Pesticide Exposure and Toxicity
- Essential Oils and Antimicrobial Activity
- Environmental Toxicology and Ecotoxicology
- Cardiac, Anesthesia and Surgical Outcomes
- Neuroscience and Neuropharmacology Research
- Medicinal Plant Research
- Computational Drug Discovery Methods
- Bioactive Compounds and Antitumor Agents
- Synthesis and biological activity
- Antioxidant Activity and Oxidative Stress
- Nausea and vomiting management
- Curcumin's Biomedical Applications
- Natural Antidiabetic Agents Studies
- Luminescence Properties of Advanced Materials
- Phytochemicals and Antioxidant Activities
- Nigella sativa pharmacological applications
King Saud University
2016-2025
University of Karachi
2024
International Center for Chemical and Biological Sciences
2024
GMC Hospital
2019-2020
Jamia Hamdard
2010-2019
Regional Research Institute of Unani Medicine
2018
Z.V.M.Unani Medical College & Hospital
2018
Institute of Zoology
2016
Riyadh Elm University
2015
Indian Institute of Toxicology Research
2008-2012
Copper oxide nanoparticles (CuO NPs) are heavily utilized in semiconductor devices, gas sensor, batteries, solar energy converter, microelectronics and heat transfer fluids. It has been reported that liver is one of the target organs for after they gain entry into body through any possible routes. Recent studies have shown cytotoxic response CuO NPs cells. However, underlying mechanism apoptosis cells due to exposure largely lacking. We explored mechanisms induced by human hepatocellular...
Abstract Copper-based compounds are promising entities for target-specific next-generation anticancer and NSAIDS therapeutics. In lieu of this, benzimidazole scaffold plays an important role, because their wide variety potential functionalizations coordination modes. Herein, we report three copper complexes 1 – 3 with benzimidazole-derived scaffolds, a biocompatible molecule, secondary ligands viz, 1–10-phenanthroline 2,2′-bipyridyl. All the have been designed, synthesized adequately...
In this study, silver nanoparticles (AgNPs) were synthesized using aqueous extract of Nepeta deflersiana plant. The prepared AgNPs (ND-AgNPs) examined by ultraviolet-visible spectroscopy, Fourier transform infrared (FTIR) X-ray diffraction (XRD), transmission electron microscopy (TEM), scanning microscope (SEM), and energy dispersive spectroscopy (EDX). results obtained from various characterizations revealed that average size was 33 nm in face-centered-cubic structure. anticancer potential...
DNA/RNA binding studies, the MTT assay and ROS generation by complex<bold>1</bold>.
Methods: We investigated the possible mechanisms of genotoxicity induced by Co 3 O 4 NPs in human hepatocarcinoma (HepG2) cells. Cell viability, reactive oxygen species (ROS), glutathione, thiobarbituric acid substance, apoptosis, and DNA damage were assessed HepG2 cells after 2+ exposure. Results: elicited a significant ( P < 0.01) reduction glutathione with concomitant increase lipid hydroperoxide, ROS generation, superoxide dismutase, catalase activity 24- 48-hour had mild cytotoxic...
ABSTRACT: Due to advent of nanotechnology, nickel nanoparticles (Ni NPs) are increasingly recognized for their utility in various applications including catalysts, sensors and electronics. However, the environmental human health effects Ni NPs have not been fully investigated. In this study, we examined toxic liver (HepG2) cells. were prepared characterized by X‐ray diffraction, transmission electron microscopy dynamic light scattering. We observed that (size, ∼28 nm; concentration range,...
Nigella sativa (N sativa), commonly known as black seed, has been used in traditional medicine to treat many diseases. The antioxidant, anti-inflammatory, and antibacterial activities of N extracts are well known. Therefore, the present study was designed investigate anticancer activity seed extract (NSE) oil (NSO) against a human lung cancer cell line. Cells were exposed 0.01 1 mg/ml NSE NSO for 24 h, then percent viability assessed by 3-(4, 5-dimethylthiazol-2yl)-2, 5-biphenyl tetrazolium...
Monocrotophos (MCP) is a commonly used organophosphorus (OP) pesticide. We studied apoptotic changes in PC12 cells exposed to MCP. A significant induction reactive oxygen species (ROS), lipid peroxide (LPO), and the ratio of glutathione disulfide (GSSG)/reduced (GSH) was observed selected doses Following exposure MCP, levels protein mRNA expressions Caspase-3, Caspase-9, Bax, p53, P(21), Puma, cytochrome-c were significantly upregulated, whereas Bcl(2), Bcl(w), Mcl1 downregulated. TUNEL...