Hisham A. Alhadlaq

ORCID: 0000-0002-3073-7025
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Research Areas
  • Nanoparticles: synthesis and applications
  • Advanced Nanomaterials in Catalysis
  • Graphene and Nanomaterials Applications
  • Heavy Metal Exposure and Toxicity
  • Osteoarthritis Treatment and Mechanisms
  • Nanoparticle-Based Drug Delivery
  • Air Quality and Health Impacts
  • Carbon and Quantum Dots Applications
  • Nanoplatforms for cancer theranostics
  • Copper-based nanomaterials and applications
  • Advanced Photocatalysis Techniques
  • Anesthesia and Neurotoxicity Research
  • Synthesis and biological activity
  • Lower Extremity Biomechanics and Pathologies
  • Polymer Nanocomposite Synthesis and Irradiation
  • Conducting polymers and applications
  • Vitamin C and Antioxidants Research
  • Gas Sensing Nanomaterials and Sensors
  • Molecular Sensors and Ion Detection
  • Electrochemical Analysis and Applications
  • Nanomaterials for catalytic reactions
  • Synthesis and Characterization of Heterocyclic Compounds
  • Nanocluster Synthesis and Applications
  • Curcumin's Biomedical Applications
  • Multicomponent Synthesis of Heterocycles

King Saud University
2015-2024

Oakland University
2005-2007

University of Rochester
2002-2004

We studied the structural and antimicrobial properties of copper oxide nanoparticles (CuO NPs) synthesized by a very simple precipitation technique. Copper (II) acetate was used as precursor sodium hydroxide reducing agent. X‐ray diffraction patter (XRD) pattern showed crystalline nature CuO NPs. Field emission scanning electron microscope (FESEM) field transmission (FETEM) demonstrated morphology The average diameter NPs calculated TEM XRD around 23 nm. Energy dispersive spectroscopy (EDS)...

10.1155/2014/637858 article EN cc-by Journal of Nanomaterials 2014-01-01

Copper oxide nanoparticles (CuO NPs) are heavily utilized in semiconductor devices, gas sensor, batteries, solar energy converter, microelectronics and heat transfer fluids. It has been reported that liver is one of the target organs for after they gain entry into body through any possible routes. Recent studies have shown cytotoxic response CuO NPs cells. However, underlying mechanism apoptosis cells due to exposure largely lacking. We explored mechanisms induced by human hepatocellular...

10.1371/journal.pone.0069534 article EN cc-by PLoS ONE 2013-08-05

Background: Therapeutic selectivity and drug resistance are critical issues in cancer therapy. Currently, zinc oxide nanoparticles (ZnO NPs) hold considerable promise to tackle this problem due their tunable physicochemical properties. This work was designed prepare SnO 2 -doped ZnO NPs/reduced graphene nanocomposites (SnO -ZnO/rGO NCs) with enhanced anticancer activity better biocompatibility than those of pure NPs. Materials Methods: Pure NPs, -ZnO) NCs were prepared via a facile...

10.2147/ijn.s285392 article EN cc-by-nc International Journal of Nanomedicine 2021-01-01

Abstract The experiments reported herein are the first MRI investigations of orientational dependence T 2 relaxation in articular cartilage at microscopic resolution over 360° angular space. For each six canine specimens, 48 independent ‐weighted proton images were acquired for 12 different specimen orientations. Pixel‐wise monoexponential fits these produced images, with an in‐plane pixel 13.7 μm. Cartilage as a function orientation was shown to follow approximately nuclear dipole–dipole...

10.1002/mrm.10216 article EN Magnetic Resonance in Medicine 2002-08-23

We investigated the anticancer potential of Ag-doped (0.5-5%) anatase TiO

10.1038/s41598-017-17559-9 article EN cc-by Scientific Reports 2017-12-11

Abstract: The widespread use of zinc oxide (ZnO) nanoparticles worldwide exposes humans to their adverse effects, so it is important understand biological effects and any associated risks. This study was designed investigate the cytotoxicity, oxidative stress, apoptosis caused by ZnO in human skin melanoma (A375) cells. MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazoliumbromide] lactate dehydrogenase-based cell viability assays showed a significant decrease after exposure...

10.2147/ijn.s42028 article EN cc-by-nc International Journal of Nanomedicine 2013-03-01

Abstract We investigated whether Aluminum (Al) doping tunes band gap energy level as well selective cytotoxicity of ZnO nanoparticles in human breast cancer cells (MCF-7). Pure and Al-doped were prepared by a simple sol-gel method. Characterization study confirmed the formation single phase Al x Zn 1-x O nanocrystals with size range 33–55 nm. Al-doping increased (from 3.51 eV for pure to 3.87 ZnO). also enhanced oxidative stress response MCF-7 cells. The IC50 undoped was 44 μg/ml while...

10.1038/srep13876 article EN cc-by Scientific Reports 2015-09-08

Iron oxide (Fe3O4) nanoparticles (IONPs) have received much attention for their utility in biomedical applications such as magnetic resonance imaging, drug delivery and hyperthermia. Recent studies reported that IONPs induced cytotoxicity mammalian cells. However, little is known about the genotoxicity of following exposure to human In this study, we investigated cytotoxicity, oxidative stress two cell lines; skin epithelial A431 lung A549. Prepared were polygonal shape with a smooth surface...

10.2174/1381612811319370011 article EN Current Pharmaceutical Design 2013-09-26

Copper oxide nanoparticles (CuO NPs) are of great interest in nanoscience and nanotechnology because their broad industrial commercial applications. Therefore, toxicity CuO NPs needs to be thoroughly understood. The aim this study was investigate the cytotoxicity, genotoxicity, oxidative stress induced by human lung epithelial (A549) cells. were synthesized solvothermal method size measured under transmission electron microscopy (TEM) found around 23 nm....

10.1177/0748233713511512 article EN Toxicology and Industrial Health 2013-12-05

Copper oxide nanoparticles (CuO NPs) are being used in several industrial and commercial products. Inhalation is one of the most significant routes metal NP exposure. Hence, toxicity CuO NPs lung tissues great concern. In vitro studies have indicated that induce cytotoxicity, oxidative stress genetic cultivated human cells. Leaching Cu ions, reactive oxygen species generation autophagy appear to be underlying mechanisms vivo on largely lacking. Some shown intratracheal instillation induced...

10.2217/nnm.15.72 article EN Nanomedicine 2015-08-01

Due to unique physicochemical properties, magnesium oxide nanoparticles (MgO NPs) have shown great potential for various applications, including biomedical and environmental remediation. Moreover, the physiochemical properties of MgO NPs can be tailored by metal ion doping that utilized in photocatalytic performance field. There is limited study on activity biocompatibility silver (Ag)-doped NPs. This was planned facile synthesis, characterization, pure In addition, cytotoxicity Ag-doped...

10.3390/nano11112915 article EN cc-by Nanomaterials 2021-10-30

The efficacy of current cancer therapies is limited due to several factors, including drug resistance and non-specific toxic effects. Due their tuneable properties, silver nanoparticles (Ag NPs) graphene derivative-based nanomaterials are now providing new hope treat with minimum side Here, we report a simple, inexpensive, eco-friendly protocol for the preparation silver-reduced oxide nanocomposites (Ag/RGO NCs) using orange peel extract. This work was planned curtail use chemicals, improve...

10.3390/polym13193350 article EN Polymers 2021-09-30

ZnO nanoparticles (NPs) have attracted great attention in cancer therapy because of their novel and tailorable physicochemical features. Pure NPs, molybdenum (Mo)-doped Mo-ZnO/reduced graphene oxide nanocomposites (Mo-ZnO/RGO NCs) were prepared using a facile, inexpensive, eco-friendly approach date palm (

10.1021/acsomega.1c06789 article EN cc-by-nc-nd ACS Omega 2022-02-15

CuO NPs is being applied for various applications including catalyst, electronics, cosmetics, and biomedicines due to its exceptional physicochemical properties. Physical chemical routes synthesis raised the concern of environmental hazard use high energy, temperature, toxic chemicals. Conversely, green procedure considered as an inexpensive eco-friendly approach. To compare in vitro bioactivities vivo toxicity, was synthesized by two different methods; routes. Leaf extract a medicinal plant...

10.1016/j.jksus.2022.102092 article EN cc-by-nc-nd Journal of King Saud University - Science 2022-05-17

ABSTRACT: Due to advent of nanotechnology, nickel nanoparticles (Ni NPs) are increasingly recognized for their utility in various applications including catalysts, sensors and electronics. However, the environmental human health effects Ni NPs have not been fully investigated. In this study, we examined toxic liver (HepG2) cells. were prepared characterized by X‐ray diffraction, transmission electron microscopy dynamic light scattering. We observed that (size, ∼28 nm; concentration range,...

10.1002/tox.21879 article EN Environmental Toxicology 2013-06-17
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