A5086414065- Computational Drug Discovery Methods
- Nuclear reactor physics and engineering
- Nuclear Materials and Properties
- Metaheuristic Optimization Algorithms Research
- Spectroscopy and Chemometric Analyses
- Optimization and Search Problems
- Nuclear Physics and Applications
- Cellular Automata and Applications
- Bioinformatics and Genomic Networks
- Advanced Mathematical Modeling in Engineering
- Ship Hydrodynamics and Maneuverability
- Advanced Multi-Objective Optimization Algorithms
- Optical Coherence Tomography Applications
- Cardiovascular Health and Disease Prevention
- Metabolomics and Mass Spectrometry Studies
- Machine Learning and Data Classification
- Traditional Chinese Medicine Studies
- Coronary Interventions and Diagnostics
- Pharmacogenetics and Drug Metabolism
- Study of Mite Species
- Nuclear and radioactivity studies
- Graphite, nuclear technology, radiation studies
- Cholinesterase and Neurodegenerative Diseases
- Spectroscopy Techniques in Biomedical and Chemical Research
- Nuclear Engineering Thermal-Hydraulics
University of Science and Technology Liaoning
2020-2024
Changchun Institute of Optics, Fine Mechanics and Physics
2024
Nanyang Technological University
2024
Anshan Hospital
2020
Idaho National Laboratory
2011-2016
Metabolism refers to a series of orderly chemical reactions used maintain life activities in organisms. In healthy individuals, metabolism remains within normal range. However, specific diseases can lead abnormalities the levels certain metabolites, causing them either increase or decrease. Detecting these deviations metabolite aid diagnosing disease. Traditional biological experiments often rely on lot manpower do repeated experiments, which is time consuming and labor intensive. To address...
The butterfly optimization algorithm (BOA) is a meta-heuristic that mimics foraging and mating behavior of butterflies. In order to alleviate the problems slow convergence, local optimum lack population diversity BOA, an enhanced adaptive (EABOA) proposed in this paper. First, new fragrance model designed, which provided finer perception way effectively convergence speed accuracy. Second, Lévy flight with high-frequency short-step jumping low-frequency long-step walking adopted help jump out...
Acute toxicity of the fathead minnow (Pimephales promelas) is an important indicator to evaluate hazards and risks compounds in aquatic environments. The aim our study explore predictive power quantitative structure-activity relationship (QSAR) model based on a radial basis function (RBF) neural network with joint optimization method acute mechanism, develop potential prediction model, for minnow. To ensure symmetry fairness data splitting generate multiple chemically diverse training...
The Caco-2 cell model is widely used to evaluate the in vitro human intestinal permeability of drugs due its morphological and functional similarity enterocytes. Although it safe relatively economic, time-consuming. A rapid accurate quantitative structure-property relationship (QSPR) helpful improve efficiency oral drug development. aim our study explore predictive ability QSPR model, permeation mechanism, develop a potential prediction for cells. In study, large data set was collected...
Drug-induced liver injury (DILI) is the major cause of clinical trial failure and postmarketing withdrawals approved drugs. It very expensive time-consuming to evaluate hepatotoxicity using animal or cell-based experiments in early stage drug development. In this study, an silico model based on joint decision-making strategy was developed for DILI assessment a relatively large dataset 2608 compounds. Five consensus models were with PaDEL descriptors PubChem, Substructure, Estate,...
The accuracy of optical coherence tomography angiography (OCTA) based blood flow velocimetry is affected by Axial Velocity Gradient (AVG) when the scanning beam not perpendicular to flow. We have developed two methods eliminate effect AVG on amplitude decorrelation, where term cancelled according established analytical model dynamic light scattering (DLS) using OCTA signals acquired with different spatial resolutions. verified both solutions phantom experiments. effectiveness and limitations...
Aiming at the problems of Flow Direction Algorithm (FDA), such as premature convergence and tendency to fall into local optimum, this paper proposes an efficient improved version named FDA_CPR. Firstly, embedding topological structure cellular automata increase population diversity algorithm. Then, Lévy flight is used replace D8 algorithm FDA a position update strategy based on Sine Cosine slow down Furthermore, new concept "potential energy" introduced calculate energy score flow determine...