A5101635487- Cellular Mechanics and Interactions
- 3D Printing in Biomedical Research
- Microfluidic and Bio-sensing Technologies
- Cancer Cells and Metastasis
- Microfluidic and Capillary Electrophoresis Applications
- Algebraic structures and combinatorial models
- Cell Image Analysis Techniques
- Homotopy and Cohomology in Algebraic Topology
- Micro and Nano Robotics
- Mathematical Biology Tumor Growth
- GNSS positioning and interference
- Innovative Microfluidic and Catalytic Techniques Innovation
- Electrowetting and Microfluidic Technologies
- Modular Robots and Swarm Intelligence
- Cold Atom Physics and Bose-Einstein Condensates
- Advanced Topics in Algebra
- Collagen: Extraction and Characterization
- Advanced Sensor and Energy Harvesting Materials
- Indoor and Outdoor Localization Technologies
- Fluid Dynamics and Heat Transfer
- Coronary Interventions and Diagnostics
- Advanced Thermodynamics and Statistical Mechanics
- Vibration Control and Rheological Fluids
- Surface Modification and Superhydrophobicity
- Gene Regulatory Network Analysis
Chongqing University
2016-2025
AviChina Industry & Technology (China)
2024
Beijing Institute of Aeronautical Materials
2010-2024
Aero Engine Corporation of China (China)
2024
Nanjing University of Information Science and Technology
2024
University of Chinese Academy of Sciences
2018-2024
Xi'an Institute of Optics and Precision Mechanics
2024
Chinese Academy of Sciences
2013-2024
Pusan National University
2019-2024
Aviation Industry Corporation of China (China)
2024
Significance Intravasation is an early stage of metastasis that involves metastatic cells moving from the tumor into extracellular matrix (ECM), breakthrough basement membrane, and entry blood vessels. We found oriented fibers greatly enhance facilitate cell intravasation process during metastasis. suggest a possible “tissue treatment” therapy could be considered, in which ECM fiber structure orientation microenvironment might altered to minimize rate cells.
Circulating tumor cells (CTCs) and circulating clusters of cancer stromal have been identified in the blood patients with malignant can be used as a diagnostic for disease severity, assess efficacy different treatment strategies possibly determine eventual location metastatic invasions possible treatment. There is thus critical need to isolate, propagate characterize viable CTCs their associated stroma cells. Here, we present microfluidic device mL/min flow rate, continuous-flow capture from...
Abstract Owing to the advantages of integration and being magnet-free light-weight, switched-capacitor-convertor plays an increasing role compared traditional transformer in some specific power supply systems. However, high output impedance switching loss largely reduces its efficiency, due imperfect topology transistors. Herein, we propose a fractal-design based switched-capacitor-convertors with characteristics including conversion minimum impedance, electrostatic voltage applicability. As...
Metabolism refers to a series of orderly chemical reactions used maintain life activities in organisms. In healthy individuals, metabolism remains within normal range. However, specific diseases can lead abnormalities the levels certain metabolites, causing them either increase or decrease. Detecting these deviations metabolite aid diagnosing disease. Traditional biological experiments often rely on lot manpower do repeated experiments, which is time consuming and labor intensive. To address...
To investigate the transition from non-cancerous to metastatic a physical sciences perspective, Physical Sciences-Oncology Centers (PS-OC) Network performed molecular and biophysical comparative studies of non-tumorigenic MCF-10A MDA-MB-231 breast epithelial cell lines, commonly used as models cancer metastasis. Experiments were in 20 laboratories 12 PS-OCs. Each laboratory was supplied with identical aliquots common reagents culture protocols. Analyses these measurements revealed dramatic...
Glioblastoma (GBM) is the most malignant and highly aggressive brain tumor. In this study, four types of typical GBM cell lines (LN229, SNB19, U87, U251) were cultured in a microfabricated 3-D model to study their vitro behaviors. The provides hollow micro-chamber arrays containing natural collagen interface thus allows cells grow chambers. showed specific properties on aspects morphology, proliferation, migration, invasion, some which rarely observed before. Furthermore, how invaded into...
We present an ecology-inspired form of active matter consisting a robot swarm. Each moves over planar dynamic resource environment represented by large light-emitting diode array in search maximum light intensity; the robots deplete (dim) locally their presence local intensity and seek intensity. Their movement is directed along steepest gradient; we call this emergent symmetry breaking motion "field drive." show there emerge spatial transitions similar to gas, crystalline, liquid, glass,...
Abstract Wearable devices integrated with various electronic modules, biological sensors, and chemical sensors have drawn large public attention. Due to their inherent advantages of superior stretchability, elaborate microstructure, high integration multiple functions, low cost, microfluidics are an excellent candidate already been widely used in wearable devices. Well‐designed microfluidic can realize functions devices, including sample collecting, handling storage, analysis, signal...
As an important group of brominated flame retardants, polybrominated diphenyl ethers (PBDEs) persist in the wildlife food webs. However, biomagnification PBDEs has not been adequately studied terrestrial In this study, a web composed common kestrels, sparrows, rats, grasshoppers, and dragonflies urban environment from northern China was obtained. A field prey delivery reinforced by δ13C δ15N analyses, indicates that sparrows are primary items kestrels. Concentrations were following order:...
Metastasis, the truly lethal aspect of cancer, occurs when metastatic cancer cells in a tumor break through basement membrane and penetrate extracellular matrix. We show that MDA-MB-231 breast cooperatively invade 3D collagen matrix while following glucose gradient. The invasion front is dynamic one, with different assuming lead on time scale 70 h. cell leadership presumably because metabolic costs associated long-range strain field precedes invading front, which we have imaged using...
Cancer cell invasion is a major component of metastasis and responsible for extensive diffusion into destruction tissues. Cells exhibit complex modes, including variety collective behaviors. This phenomenon results in the structural heterogeneity extracellular matrix (ECM) Here, we systematically investigated environmental facilitating tumor via combination vitro migration experiments computer simulations. Specifically, constructed an ECM microenvironment microfabricated biochip successfully...
Abstract Percutaneous coronary intervention (PCI), especially stent implantation, has been shown to be an effective treatment for artery disease. However, in-stent restenosis is one of the longstanding unsolvable problems following PCI. Although stents implanted inside narrowed vessels recover normal flux blood flows, they instantaneously change wall shear stress (WSS) distribution on vessel surface. Improper implantation positions bring high possibilities as it enlarges low WSS regions and...
Cell migration is essential for regulating many biological processes in physiological or pathological conditions, including embryonic development and cancer invasion. In vitro silico studies suggest that collective cell associated with some biomechanical particularities such as restructuring of extracellular matrix (ECM), stress force distribution profiles, reorganization the cytoskeleton. Therefore, phenomenon could be understood by an in-depth study cells' behavior determinants, but not...
Previous studies on light-driven droplet transport often use light to heat the substrate generate a temperature difference, thereby changing wettability or surface tension at two ends of droplet, propel forward, and not much attention has been paid droplets with photothermal properties. Herein, we introduce method ink manipulation via near infrared lubricant infused surfaces. Rather than heating itself, this uses near-infrared irradiate one end an creating gradient inside it forming...
Drop impacts on compound or patterned surfaces have been widely studied as these can significantly enhance the richness and diversity of outcomes. In this work, a simple preparation strategy for surface with temperature gradient is presented, impact ethanol drops such systematically investigated. The experiments reveal that gives rise to stiffness gradient. Both gradients make splash phenomenon drop more diverse. Moreover, also leads changes in physical properties liquid during spreading,...
Abstract The use of robotic swarms to study the properties active matter is a common experimental approach. In such studies, robots are often required possess capabilities in computation, storage, perception, and two-dimensional movement execute predefined rules. Under these rules, swarm can accomplish complex tasks, exhibit rich collective states, or demonstrate intriguing phase transition phenomena. However, this demonstrates how spin robots, which only respond simple ambient light...
Suppose that E=A[x;\sigma,\delta] is an Ore extension with \sigma automorphism. It proved if A twisted Calabi–Yau of dimension d , then E d+1 . The relation between their Nakayama automorphisms also studied. As application, the a class 5-dimensional Artin–Schelter regular algebras are given explicitly.
Cell migration in fibreous extracellular matrix (ECM) is crucial to many physiological and pathological processes such as tissue regeneration, immune response cancer progression. During migration, individual cells can generate active pulling forces via actin filament contraction, which are transmitted the ECM fibers through focal adhesion complexes, remodel ECM, eventually propagate be sensed by other system. The microstructure physical properties of also significantly influence cell e.g.,...
To analyse the impact and repercussions of surge in healthcare demand response to COVID-19 pandemic, assess potential effectiveness various infection/disease control measures, make projections on best approach exit from current lockdown.A four-compartment model was constructed for SARS-CoV-2 infection based Wuhan data validated with collected Italy, UK, US. The captures disease suppression measures three modifiable factors: (a) per capita contact rate (β) that can be lowered by means social...
Correlated cell migration in fibrous extracellular matrix (ECM) is important many biological processes. During migration, cells can remodel the ECM, leading to formation of mesoscale structures such as fiber bundles. However, how regulate correlated single-cells remains be elucidated. Here, using a quasi-3D vitro model, we investigate collagen bundles are dynamically re-organized and guide migration. By combining laser ablation technique with 3D tracking active-particle simulations,...
In shotgun proteomics, the proteome search engine analyzes mass spectra obtained by experiments, and then a peptide-spectra match (PSM) is reported for each spectrum. However, most of PSMs identified are incorrect, therefore various postprocessing software have been developed reranking peptide identifications. Yet these methods suffer from issues such as dependency on distribution, reliance shallow models, limited effectiveness. this work, we propose AttnPep, deep learning model rescoring...
This study investigates how deviation angles close to the [001] orientation affect tensile properties and deformation behavior of a nickel-based single-crystal superalloy at room temperature. The research focuses on samples with 3°, 8°, 13° from examines their strength ductility. We employed scanning electron microscopy (SEM), backscatter diffraction (EBSD), transmission (TEM) explore micro-mechanisms varying angles. Findings reveal that decreases ductility increases as angle widens within...
This study assesses the impact of secondary orientations on tensile deformation behavior single-crystal superalloys at mid-temperature 760 °C. Tensile tests and stress-strain analyses were performed specimens with primary orientation [001] [100], [410], [110]. Stress distributions modeled using Abaqus software, while fracture behavior, slip system activation, oxidation, lattice rotation, micro-dislocation movements investigated optical microscopy (OM), scanning electron (SEM),...
We report the design and fabrication of a chaotic mixer based on electrorheological (ER) fluid-controlled valves. The flow in main channel is perturbed by liquid orthogonal side channels, driven hydrodynamic pulsating pumps. Each pump consists chamber with diaphragm plus two out-of-phase ER valves operating push-pull mode. All valves, pumps, mixing channels are integrated one polydimethylsioxane chip. Mixing characteristics controlled strength frequency external electric fields applied fluid.