A5049356211- Inflammatory mediators and NSAID effects
- Cytokine Signaling Pathways and Interactions
- Immune cells in cancer
- RNA Research and Splicing
- Epigenetics and DNA Methylation
- Plant Molecular Biology Research
- Peroxisome Proliferator-Activated Receptors
- Genomics and Chromatin Dynamics
- RNA and protein synthesis mechanisms
- Horticultural and Viticultural Research
- Plant Gene Expression Analysis
- Cancer-related gene regulation
- TGF-β signaling in diseases
- Plant Stress Responses and Tolerance
- Cancer-related molecular mechanisms research
- Immune Response and Inflammation
- Cutaneous Melanoma Detection and Management
- Plant Pathogens and Fungal Diseases
- Medicine and Dermatology Studies History
- RNA modifications and cancer
- Silk-based biomaterials and applications
- Nuts composition and effects
- Genetic Syndromes and Imprinting
- Light effects on plants
- PARP inhibition in cancer therapy
European Institute of Oncology
2013-2023
Istituti di Ricovero e Cura a Carattere Scientifico
2020-2023
Humanitas University
2018
University of Milan
2009-2012
Myeloid-derived suppressor cells (MDSC) include immature monocytic (M-MDSC) and granulocytic (PMN-MDSC) that share the ability to suppress adaptive immunity hinder effectiveness of anticancer treatments. Of note, in response IFNγ, M-MDSCs release tumor-promoting immunosuppressive molecule nitric oxide (NO), whereas macrophages largely express antitumor properties. Investigating these opposing activities, we found tumor-derived prostaglandin E2 (PGE2) induces nuclear accumulation p50 NF-κB...
Abstract The enzymes of the poly-ADP-ribose polymerase (PARP) superfamily control many relevant cellular processes, but a precise understanding their activities in different physiological or disease contexts is largely incomplete. We found that transcription several Parp genes was dynamically regulated upon murine macrophage activation by endotoxin. PARP14 strongly induced inflammatory stimuli and translocated into nucleus stimulated cells. Quantitative mass spectrometry analysis showed...
Abstract Background MicroRNAs are short (~21 base) single stranded RNAs that, in plants, generally coded by specific genes and cleaved specifically from hairpin precursors. critical for the regulation of multiple developmental, stress related other physiological processes plants. The recent annotation genome grapevine ( Vitis vinifera L.) allowed identification many putative conserved microRNA precursors, grouped into gene families. Results Here we use oligonucleotide arrays to provide first...
Plant responses to drought are regulated by complex genetic and epigenetic networks leading rapid reprogramming of plant growth. miRNAs have been widely indicated as key players in the regulation growth development. The role response was investigated young leaves Brachypodium distachyon, a drought-tolerant monocot model species. Adopting an vivo assay, shown cause dramatic reduction leaf size, mostly due reduced cell expansion, small RNA libraries were produced from proliferating expanding...
Transcription termination pathways mitigate the detrimental consequences of unscheduled promiscuous initiation occurring at hundreds thousands genomic cis -regulatory elements. The Restrictor complex, composed Pol II-interacting protein WDR82 and RNA-binding ZC3H4, suppresses processive transcription extragenic sites in mammalian genomes. Restrictor-driven does not involve nascent RNA cleavage, its interplay with other machineries is unclear. Here we show that efficient Restrictor-controlled...
<div>Abstract<p>Myeloid-derived suppressor cells (MDSC) include immature monocytic (M-MDSC) and granulocytic (PMN-MDSC) that share the ability to suppress adaptive immunity hinder effectiveness of anticancer treatments. Of note, in response IFNγ, M-MDSCs release tumor-promoting immunosuppressive molecule nitric oxide (NO), whereas macrophages largely express antitumor properties. Investigating these opposing activities, we found tumor-derived prostaglandin E2 (PGE2) induces...
<p>Association of each induced gene to the nearest STAT1 peak according distance between TSS (Transcription Start Site) and summit peaks.</p>
<p>Stat1 peaks detected in p50-/- PEC stimulated with IFNγ for 2 hours as compared to WT PEC</p>
<p>selective gene expression alterations in p50-/- PEC stimulated with IFNγ for 4 hours as compared to WT PEC</p>
<p>supplementary figures and Materials & Methods</p>
<p>selective gene expression alterations in p50-/- M-MDSC stimulated with IFNγ for 4 hours as compared to WT M-MDSC</p>
<p>selective gene expression alterations in p50-/- M-MDSC stimulated with IFNγ for 4 hours as compared to WT M-MDSC</p>
<p>Stat1 peaks detected in p50-/- PEC stimulated with IFNγ for 2 hours as compared to WT PEC</p>
<p>supplementary figures and Materials & Methods</p>
<p>Association of each induced gene to the nearest STAT1 peak according distance between TSS (Transcription Start Site) and summit peaks.</p>
<p>selective gene expression alterations in p50-/- PEC stimulated with IFNγ for 4 hours as compared to WT PEC</p>
<div>Abstract<p>Myeloid-derived suppressor cells (MDSC) include immature monocytic (M-MDSC) and granulocytic (PMN-MDSC) that share the ability to suppress adaptive immunity hinder effectiveness of anticancer treatments. Of note, in response IFNγ, M-MDSCs release tumor-promoting immunosuppressive molecule nitric oxide (NO), whereas macrophages largely express antitumor properties. Investigating these opposing activities, we found tumor-derived prostaglandin E2 (PGE2) induces...