A5034168411- Inflammasome and immune disorders
- Calcium signaling and nucleotide metabolism
- Biomarkers in Disease Mechanisms
- Autophagy in Disease and Therapy
- Erythrocyte Function and Pathophysiology
- Autoimmune and Inflammatory Disorders Research
University of Calgary
2021-2022
Recognition of pathogen-or-damage-associated molecular patterns is critical to inflammation. However, most exist within intact microbes/cells and are typically part non-diffusible, stable macromolecules that not optimally immunostimulatory or available for immune detection. Partial digestion following phagocytosis potentially generates new diffusible patterns, however, our current understanding phagosomal biology would have these molecules sequestered destroyed phagolysosomes. Here, we show...
Respiratory silicosis is a preventable occupational disease that develops secondary to the aspiration of crystalline silicon dioxide (silica) into lungs, activation NLRP3 inflammasome, and IL-1β production. Cathepsin Z has been associated with development inflammation production; however, mechanism how cathepsin leads production unknown. Here, requirement for in was determined using WT mice deficient Z. The inflammasome macrophages studied Z-deficient bone marrow-derived murine dendritic...