About
Contact & Profiles
A5052585017
Research Areas
- Epilepsy research and treatment
- Computational Drug Discovery Methods
- Neuroscience and Neuropharmacology Research
- Drug Transport and Resistance Mechanisms
- Pharmacological Effects and Toxicity Studies
- Trypanosoma species research and implications
- Educational Technology in Learning
- Viral Infectious Diseases and Gene Expression in Insects
- Phenothiazines and Benzothiazines Synthesis and Activities
- Receptor Mechanisms and Signaling
- Machine Learning in Bioinformatics
- Lipid Membrane Structure and Behavior
- Ion channel regulation and function
- Salivary Gland Tumors Diagnosis and Treatment
- Phosphodiesterase function and regulation
Universidad Nacional de La Plata
2016-2020
The purpose of this investigation is to contribute the development new anticonvulsant drugs treat patients with refractory epilepsy. We applied a virtual screening protocol that involved search into molecular databases compounds and known find small molecules interact open conformation Nav1.2 pore. As 3D structure human not available, we first assembled models target, in closed conformations. After screening, resulting candidates were submitted second filter, better chances being effective...
10.1021/acs.jcim.7b00721
article
EN
Journal of Chemical Information and Modeling
2018-06-05
10.1016/j.yebeh.2019.106451
article
EN
Epilepsy & Behavior
2019-08-13
10.1016/j.ejphar.2016.02.001
article
EN
European Journal of Pharmacology
2016-02-02
10.1016/j.eplepsyres.2016.10.012
article
EN
Epilepsy Research
2016-10-27
Coming Soon ...