A5019398807- Supramolecular Self-Assembly in Materials
- Chemical Synthesis and Analysis
- Advanced Polymer Synthesis and Characterization
- Force Microscopy Techniques and Applications
- Polydiacetylene-based materials and applications
- Molecular Junctions and Nanostructures
- Polymer Surface Interaction Studies
- Hydrogels: synthesis, properties, applications
- Silicon Carbide Semiconductor Technologies
- Surface Modification and Superhydrophobicity
- Nanofabrication and Lithography Techniques
- Advanced biosensing and bioanalysis techniques
- Dendrimers and Hyperbranched Polymers
- RNA Interference and Gene Delivery
- Advanced Sensor and Energy Harvesting Materials
- biodegradable polymer synthesis and properties
- Silk-based biomaterials and applications
- Conducting polymers and applications
- Connective tissue disorders research
- Advanced DC-DC Converters
- Dielectric materials and actuators
- Multilevel Inverters and Converters
- Polymer composites and self-healing
- Adhesion, Friction, and Surface Interactions
- Glycosylation and Glycoproteins Research
Doshisha University
2016-2025
University of Minnesota
2024
Kyocera (Japan)
2015-2021
Toyota Central Research and Development Laboratories (Japan)
2018
National Institute of Advanced Industrial Science and Technology
2002-2012
Tohoku University
2012
Kyushu University
1996-2007
Japan Synchrotron Radiation Research Institute
2007
SPring-8
2007
Fuji Electric (Japan)
1996-2005
Micropatterned fluoroalkylsilane monolayer surfaces with liquidphilic/liquidphobic area (line width 1-20 microm) were prepared few defects by vacuum ultraviolet (VUV) photolithography. The anisotropic wetting of a macroscopic droplet 0.5-5 mm diameter on the micropatterned was investigated. strong anisotropy contact angle and sliding distortion for fluoroalkylsilane/silanol patterned attributed to difference in energy barrier between parallel orthogonal lines. decreased decreases...
A novel method for the control of peptide self-assembly has been developed by using synthetic triblock-type β-sheet peptides composed l- or d-amino acid, 1L and 1D, as building blocks. The 1D self-assemble into nanofibers with left- right-handed twists, respectively, under appropriate condition. On other hand, 1L/1D binary mixture was found to form only globular aggregates at same Thus, amyloid-like nanofiber formation its nanostructure could be successfully regulated stereospecificity...
Abstract The elastic modulus of hydrogels is one the most important factors for controlling cell fate. In this study, composed poly( N ‐acryloylglycinamide) (PNAGAm) grafted with arginine (R)–glycine (G)–aspartic acid (D)–serine (S) peptide designed without a chemical crosslinker. are prepared by conventional radical copolymerization ‐acryloylglycinamide polymerizable RGDS peptide. grafting ratio easily controlled adjusting feed composition polymerization. exhibit thermo‐responsiveness upper...
Abstract Herein, the formation of unique shape‐memory hydrogels that are composed thermo‐responsive amino‐acid‐derived vinyl polymer networks is reported; these readily prepared by radical copolymerization N ‐acryloyl glycinamide with commercially available cross‐linkers, namely, methylenebis(acrylamide) and poly(ethylene glycol) diacrylate. These transparent (>90% transmittance at 600 nm) comprised 97–70 wt% water. Furthermore, contain both chemical physical cross‐linkages based on...
Abstract Amino acid‐derived vinyl polymers are of great interest as bio‐based thermoresponsive soft materials with diverse applications in the industrial, biomedical, and cosmetic fields. In this study, 14 distinct core‐crosslinked stars (CCS) synthesized by reversible addition–fragmentation chain transfer polymerization N ‐acryloyl amino acid (X)‐methyl esters (X = alanine, β‐alanine, or glycine), followed a core–gel approach. These CCS have following systematic variations their molecular...
A thermo-responsive polymer system showing widely tunable UCST/LCST behaviors from amino acid-based vinyl polymers.
Widespread alterations in RNA alternative splicing (AS) have been identified adult gliomas. However, their regulatory mechanism, biological significance, and therapeutic potential remain largely elusive. Here, using a computational approach with both bulk single cell RNA-sequencing, we uncover prognostic AS signature linked neural developmental hierarchies. Using advanced iPSC glioma models driven by driver mutations, show that this could be enhanced EGFRvIII inhibited situ IDH1 mutation....
The molecular aggregation state of octadecylsiloxane monolayers on Si-wafer substrate surfaces prepared from octadecyltrimethoxysilane (OTMS) or octadecyltrichlorosilane (OTS) was investigated the basis grazing incidence X-ray diffraction (GIXD), Fourier transform infrared spectroscopy (FT-IR), contact angle measurement, field emission scanning electron microscopy (FE-SEM), and force (SFM). OTMS monolayer by using chemical vapor adsorption (CVA) method, OTS monolayers, which were used as...
In this study, we report the fabrication and characterization of self-healing shape-memorable hydrogels, mechanical properties which can be tuned via post-polymerization crosslinking. These hydrogels were constructed from a thermo-responsive poly(N-acryloyl glycinamide) (NAGAm) copolymer containing N-acryloyl serine methyl ester (NASMe) units (5 mol%) that readily synthesized conventional radical copolymerization. This transparent free-standing hydrogel is produced multiple hydrogen bonds...
Abstract The self‐assembly of peptides and proteins into β‐ sheet‐rich high‐order structures has attracted much attention as a result the characteristic nanostructure these assemblies because their association with neurodegenerative diseases. Here we report structural conformational properties peptide‐conjugated graft copolymer, poly( γ ‐methyl‐ L ‐glutamate) grafted polyallylamine ( 1 ) in water‐2,2,2‐trifluoroethanol solution simple model for amyloid formation. Atomic force microscopy...
A novel multiblock hybrid copolymer composed of a β-sheet peptide and glycine-derived vinyl polymer was developed to achieve single-chain folding into well-defined nanoparticles.
Abstract Here, we report a novel, programmable, molecular self‐assembling system to fabricate shape‐specific, three‐dimensional nanoarchitectures. Three types of simple 16‐mer peptides consisting hydrophobic Leu and hydrophilic Lys, LKL16, KLK16, LK16, were prepared as building blocks for nanofabrications. A detailed analysis the conformation mechanism was performed by using circular dichroism (CD), FTIR spectroscopy, atomic force microscopy (AFM). wide variety self‐assembled...
A hybridization of structurally regulated biopolymers and conventional synthetic polymers offers promising opportunities to design novel polymeric nanomaterials. In this study, we newly prepared an amphiphilic triblock copolymer with β-sheet forming peptide as a central block, polystyrene-block-tetra(leucine)-block-poly(ethylene glycol) (PS-L4-PEG), by combining the solid phase synthesis atom transfer radical polymerization (ATRP). On basis several morphological structural analyses using...
Significant challenges have gone into the design of smart hydrogels, with numerous potential applications in industrial, cosmetic, and biomedical fields. Herein, we report synthesis novel 4-arm self-assembling peptide–polyethylene glycol (PEG) hybrid star-shaped polymers their comprehensive hydrogel properties. β-sheet-forming oligopeptides alternating hydrophobic Leu/ionizable Glu repeats Cys residues were successfully conjugated to PEG via a thiol–maleimide click reaction. The demonstrated...
Abstract Fabricating robust shape‐memory hydrogels that respond to multiple external stimuli is an important challenge in facilitating gel technology for versatile applications. In this study, we report a simple approach constructing thermo‐, redox‐, and photo‐responsive with high mechanical strength shape fix/memory capability. Upper critical solution temperature (UCST)‐type amino acid‐based were facilely prepared by radical copolymerization of N ‐acryloyl glycinamide (NAGAm)...
The attachment of peptides to the surface spherical dendrimers via graft polymerization is described here (see Figure). It shown that resulting peptide display greatly enhanced helicity compared non-dendrimer-based analogues. This effect attributed aggregation segments on dendrimer surface.
Abstract The preparation of a novel peptide/dendrimer hybrid is reported in which an elastin‐like oligopeptide successfully assembled onto poly(amidoamine) dendrimer surface (G4‐ELP), and its unique thermo‐responsive behavior discussed. As result, the G4‐ELP found to exhibit LCST pH range 3–10 including physiological temperature under neutral‐pH conditions. Moreover, cooperative interplay between folding state ELP shell ionization core enables control widely by variation. This achievement...
Nitroxide-mediated polymerization of a wide variety vinyl monomers using novel TIPNO-based cyclic peptide successfully provided multiblock architectures composed sequential peptides and polymers in one step.
This study examines the monolayer properties of a novel amphiphilic diblock polymer poly(γ-benzyl-l-glutamate) (PBLG)-block-poly(l-glutamic acid) (PLGA) (PBLG-b-PLGA) at air−water interface and binding α-amino acids such as tryptophan, tyrosine, phenylalanine to surfaces. The block polymer, PBLG-b-PLGA, was synthesized via two steps: first PLGA prepared by polymerization γ-benzyl-l-glutamate-N-carboxylic anhydride (BLG-NCA) with propylamine then removal benzyl group, subsequently BLG-NCA...
Abstract Molecular aggregation structure of poly(fluoroalkyl acrylate) [PFA-Cy, where y is the fluoromethylene number fluoroalkyl (Rf) groups] thin films was characterized by grazing-incidence X-ray diffraction (GIXD). In-plane diffractions corresponding to hexagonal packing Rf groups were measured for PFA-Cy with ≥ 8 in surface and bulk regions. This result indicated that oriented almost perpendicular film surface.