A5011103547- Cancer Genomics and Diagnostics
- Lung Cancer Treatments and Mutations
- Genetic factors in colorectal cancer
- RNA modifications and cancer
- Ovarian cancer diagnosis and treatment
- Uterine Myomas and Treatments
- Endometrial and Cervical Cancer Treatments
- Colorectal Cancer Treatments and Studies
- Gastric Cancer Management and Outcomes
- Molecular Biology Techniques and Applications
- BRCA gene mutations in cancer
Kocaeli Üniversitesi
2019-2025
Objective: Understanding the relationship between genetic structure and molecular changes involved in endometrial cancer (EC) provides an opportunity to personalize treatments incorporate targeted therapies.Method: We compared cytogenetic features observed tumoral adjacent healthy tissue endometrium samples EC patients.Results: Non-clonal chromosome aberrations (NCCAs) frequently patients with EC, especially 10,15,17,22, X chromosomes were monitored 73.7%, clonal chromosomal alterations...
Objective: RAS genes are members of the RAS/Mitogen activated protein kinase pathway which is induced by Epidermal Growth Factor Receptor (EGFR). Mutations in this trigger cancer development. In colorectal cancer, mutations cause resistance to EGRF- targeted therapy. treatment metastatic EGFR’s monoclonal antibodies widely used as chemotherapeutic agents. Kirsten-RAS found 30-50% and N-RAS 2-3% cancer. study, we aimed analyze /N-RAS patients with Methods: One hundred resistant EGFR- therapy...
Breast cancer is the most prevalent malignancy in women worldwide. Although pathogenic variants BRCA1/2 genes are responsible for majority of hereditary breast cases, a substantial proportion patients negative variations these genes. In cancers, signal transduction pathways cell usually affected first. Therefore, this study aimed to detect and classified genetic non-BRCA signaling investigate underlying causes susceptibility cancer.Ninety-six without who met inclusion criteria were enrolled...