In lipoatrophic diabetes, a lack of fat is associated with insulin resistance and hyperglycemia. This in striking contrast to the usual association diabetes obesity. To understand underlying mechanisms, we transplanted adipose tissue into A-ZIP/F-1 mice, which have severe form diabetes. Transplantation wild-type reversed hyperglycemia, dramatically lowered levels, improved muscle sensitivity, demonstrating that mice caused by tissue. All aspects phenotype including hyperphagia, hepatic...

Vasovagal (vasodepressor) fainting was studied in three different situations: persons donating blood, having a simple venipuncture, and patients undergoing pneumoencephalography. Ten faints were observed the first situation, 7 second 6 third. In all instances, faint itself, characterized by low blood pressure bradycardia, phase of diphasic response; rapid or rising heart rate, pressure, especially diastolic. The data are compatible with view that (hyperdynamic) is reflection anxiety, while...

Available evidence suggests that the sensation of itching is closely related to pain (1). Titchener (2) observed when skin was explored with a fine hair, well-defined points were found which gave rise intensity stimulation low, and on stronger stimulation. Bishop (3) resulted from repetitive low electrical spots in skin. Lewis, Grant Marvin (4) pointed out noxious stimuli, if their be decreased, can made produce instead pain. Forster (5) Bickford (6) reported patients who had

Four hundred and fourteen consecutive blood donors to a hospital bank were studied discover items of value in predicting the occurrence "reactions." Since it is probable that donor "reactions" are almost always vasovagal faints, they so referred below. Several predictive found: none 62 Negroes, but 63 352 white persons fainted; younger donor, more likely faint; higher resting pulse rate before venipuncture, admission "nervousness" was associated with greater chance fainting than denial. Sex,...

The effect of ethanol on spontaneously released acetylcholine (ACh) was studied in rabbits with cortical collecting cups and push-pull cannulas. investigation designed to examine the possibility that behavioral depression produced by acute doses is consequence impaired central cholinergic transmission. Spontaneously ACh collected Locke's solution, containing physostigmine, held acrylic over parietal cortex unanesthetized but immobilized during consecutive 15-minute periods. Ethanol, 0.5, 1.0...

A specificity of attitude hypothesis, developed originally from the clinical study patients with various psychosomatic diseases, was tested experimentally by suggesting attitudes to normal subjects and measuring concomitant changes in skin temperature hand. The hypothesis states that each toward a disturbing situation is associated its own specific disease or set physiological changes. Subjects were hypnotized as an aid inducing desired told assume original had found be hives Raynaud's...

The association of urticaria with stressful life situations has been observed by numerous authors,¹but there are few available data concerning the mechanisms involved. Grant, Pearson and Comeau,^1bwho studied that occurs exercise, warming body "emotion," found parasympathomimetic drugs produced in susceptible persons. Hopkins, Kesten Hazel^1cconfirmed these observations. They inferred their patients represented an allergic reaction to acetylcholine released at...

A specificity-of-attitude hypothesis, proposed by Grace and Graham,3 stated that there is a specific relation between the attitude towards stressful stimulus disease which occurs in response to stimulus. Two interview studies with hospitalized patients investigated whether attitudes predicted be associated diseases were more applicable having question than who did not have disease. There 16 eight first study, 20 patients' ten second study. Half of patients, matched for disease, interviewed...

A specificity-of-attitude hypothesis for psychosomatic disease was tested experimentally by means of hypnotic suggestion attitudes. Twenty healthy male subjects were given two attitude suggestions on each 2 days, with the order presentation reversed second day. The attitudes employed those associated hives (the subject felt that he being unjustly treated and could think nothing wanted to do about it), hypertension (he had be guard against bodily assault). It predicted skin temperatures would...

BACKGROUND: Fear is an important contributor to the risk of presyncopal reactions blood donation. However, concern that asking donors about their fears may increase a potential impediment incorporating fear assessment into donor screening. STUDY DESIGN AND METHODS: Before donation, participants responded series questions either did (n = 488) or not 494) include related seeing drawn. Immediately after donation all provided ratings reactions. RESULTS: Among those asked predonation questions,...

The mind-body problem is of practical importance in medicine. Current thinking about it confused, and leads to significant errors considering health disease dealing with individual patients. "Psychological" "physical" cannot usefully be thought as referring different kinds states or events; rather, they are names but parallel languages that may used for describing exactly the same events. "Functional" "organic" at best useless concepts worst seriously misleading. "Psychogenic" meaningfully...

Summary Observations of changes in the minute vessels (capillaries and venules) arterioles forearm skin were made 19 patients with various diseases at times experimentally induced emotional disturbances. An attitude hostility (a wish to take directly aggressive action) was associated constriction increased tone vessels. Such found be an invariable accompaniment major attacks Raynaud's disease 4 women this condition who studied. The Raynaud phenomenon itself consists both It is suggested that...

Abstract This study examines the effects of social media use on anxiety levels Australian Jews during 5-week post-October 7 aftermath. It considers this relationship in context mediating roles played by concerns about rising antisemitism Australia and Israel. further moderating these relationships non-Jewish friends reaching out with messages sympathy concern, Jewish communal ties. The analysis is based data collected from 7611 adults employs a series ordinary least squares regression...

The insulin receptor initiates action by phosphorylating multiple intracellular substrates. Previously, we have demonstrated that substrates (IRS)-1 and -2 can mediate insulin's to promote translocation of GLUT4 glucose transporters the cell surface in rat adipose cells. Although IRS-1, -2, -4 are similar overall structure, IRS-3 is approximately 50% shorter differs with respect sites tyrosine phosphorylation. Nevertheless, as this study, both IRS-4 also stimulate GLUT4. Rat cells were...

Collagenase clostridium histolyticum is now established as an effective and safe option to treat patients with a single joint affected Dupuytren's contracture. We have extended its use natatory combined cords. In prospective consecutive series of 298 cords in 237 patients, the mean total extension loss improved crossing metacarpophalangeal from 46° 1°, proximal interphalangeal 56° 7°, 130° 25° 102° 16°. The immediate correction was less reliable than that obtained or joint. Less severe...

The cellular compatibility of each several brands urinary catheters available on the Australian market was measured by means cellculture methods, a rabbit intramuscular implant test, and traditional mouse systemic toxicity test. Good agreement obtained between in-vitro tests (although were simpler, more rapid, sensitive, quantitative). test insensitive, detected no toxic samples. rabbit-implant results indicated that some can release substances harmful to mammalian cells. Such may contribute...