A5041452442- Fibromyalgia and Chronic Fatigue Syndrome Research
- Musculoskeletal pain and rehabilitation
- Pain Mechanisms and Treatments
- Pain Management and Opioid Use
- Pediatric Pain Management Techniques
- Cannabis and Cannabinoid Research
- Pain Management and Placebo Effect
- Anesthesia and Pain Management
- Biochemical effects in animals
- Botulinum Toxin and Related Neurological Disorders
- Spine and Intervertebral Disc Pathology
- Health Systems, Economic Evaluations, Quality of Life
- Myofascial pain diagnosis and treatment
- Phytoestrogen effects and research
- Diet and metabolism studies
- Pharmacology and Obesity Treatment
- Opioid Use Disorder Treatment
- Health, psychology, and well-being
- Pain Management and Treatment
- Trigeminal Neuralgia and Treatments
- Eating Disorders and Behaviors
- Cardiac, Anesthesia and Surgical Outcomes
- Anesthesia and Sedative Agents
- Pharmacological Effects of Natural Compounds
- Workplace Health and Well-being
McGill University Health Centre
2015-2025
McGill University
2008-2024
Edwards (United Kingdom)
2010-2023
Montreal General Hospital
2004-2021
JSS Medical Research (India)
2014-2021
Jewish General Hospital
2014-2021
Klinikum Saarbrücken
2019
Technical University of Munich
2019
Iran University of Medical Sciences
2015
Shiraz University of Medical Sciences
2015
Chronic pain is associated with reduced brain gray matter and impaired cognitive ability. In this longitudinal study, we assessed whether neuroanatomical functional abnormalities were reversible dependent on treatment outcomes. We acquired MRI scans from chronic low back (CLBP) patients before ( n = 18) 6 months after (spine surgery or facet joint injections; 14) treatment. addition, scanned 16 healthy controls, 10 of which returned the first visit. performed cortical thickness analysis...
BACKGROUND: Recent neurophysiological evidence attests to the validity of fibromyalgia (FM), a chronic pain condition that affects >2% population. OBJECTIVES: To present evidence-based guidelines for diagnosis, management and patient trajectory individuals with FM. METHODS: A needs assessment following consultation diverse health care professionals identified questions pertinent various aspects literature search available address these questions; was graded according standards Oxford...
In Brief BACKGROUND: Sleep disorders affect many patients with chronic pain conditions. Cannabis has been reported by several patient populations to help sleep. We evaluated the safety and efficacy of nabilone, a synthetic cannabinoid, on sleep disturbance in fibromyalgia (FM), disease characterized widespread insomnia. METHODS: conducted randomized, double-blind, active-control, equivalency crossover trial compare nabilone (0.5–1.0 mg before bedtime) amitriptyline (10–20 FM Subjects...
Abstract Fibromyalgia (FM) is a prevalent syndrome, characterised by chronic widespread pain, fatigue, and impaired sleep, that challenging to diagnose difficult treat. The microbiomes of 77 women with FM 79 control participants were compared using 16S rRNA gene amplification whole-genome sequencing. When comparing patients unrelated controls differential abundance analysis, significant differences revealed in several bacterial taxa. Variance the composition was explained FM-related...
In a previous report we presented novel behavioral model of neuropathic pain disorders, produced in rat by unilateral ligation about half the sciatic nerve. The is characterized rapid onset behaviors suggesting spontaneous and disordered responses to non-noxious noxious stimuli. These include reduced withdrawal thresholds repetitive touch partially deafferented skin ('touched-evoked hyperesthesia'), touch-evoked allodynia, thermal stimuli exaggerated heat mechanical ('thermal hyperalgesia')....
We previously reported that effective treatment of chronic low back pain (CLBP) reversed abnormal brain structure and functional MRI (fMRI) activity during cognitive task performance, particularly in the left dorsolateral prefrontal cortex (DLPFC). Here, we used resting-state fMRI to examine how affects connectivity networks supporting functioning effect 14 CLBP patients 16 healthy, pain-free controls (scans were acquired at baseline for all subjects 6-months post-treatment a matched...
Objectives Patient Global Rating of Change (GRC) scales are commonly used in routine clinical care given their ease use, availability and short completion time. This analysis aimed at assessing the validity Impression (PGIC), a GRC scale fibromyalgia, Canadian real-life setting. Methods 167 fibromyalgia patients with available PGIC data were recruited 2005–2013 from tertiary-care multidisciplinary clinic. In addition to PGIC, disease severity was assessed with: pain visual analogue (VAS);...
Aim. This paper reports a study to compare nurses’ ratings of pain intensity and suffering (affect) in adult surgical patients with patients’ own these variables, investigate whether were influenced by cultural ethnic differences. Background. Studies show that postoperative continues be under‐treated large proportion cases. The problem may partly due inaccurate assessment nurses. Method. A convenience sample 95 nurses units was selected from four hospitals Jerusalem, Israel 2003–2004....
Although preemptive analgesia has been shown to decrease postinjury pain in animals, studies humans have provided controversial results. The authors studied whether surgical epidural anesthesia with local anesthetics could affect postoperative and analgesic demands, when compared general anesthesia.Male patients scheduled for radical retropubic prostatectomy were randomly assigned receive only (EA, n = 34), combined (EG, 32), or (GA, 30). A lumbar catheter was inserted tested all patients....
Temporomandibular pain disorder (TMD) is a common condition in the face. People with TMD report multiple comorbidities. The presence of fibromyalgia and migraine people associated an increase intensity duration. However, data on relationship between increasing number comorbidities are rare. aims this study were: firstly to evaluate extent which duration; secondly specific sample included 180 seeking treatment at Boston Montreal clinics. was diagnosed using Research Diagnostic Criteria for...
In some rat strains, total hindpaw denervation triggers autotomy, a behavior of self mutilation presumably related to neuropathic pain. Partial sciatic ligation (PSL) in rats produces tactile allodynia and heat hyperalgesia but not autotomy. Our aims this study were examine: (1) whether sensibility intact noxious non-noxious stimuli is strain-dependent; (2) could predict levels or the PSL model; (3) autotomy are correlated with hyperalgesia. Here we report that two inbred strains (Lewis...
Background: Impaired pulmonary functions are common in cardiac patients. Early and late effects of surgery on function tests (PFTs) presented. Methods: Fifty patients undergoing (coronary artery bypass grafting [CABG, 74%], valve replacement or val‐vuloplasty [20%] combined procedures [6%]) were studied. Anginal failure symptoms severity, smoking history, evaluated preoperatively. PETS studied compared pre‐, 3 weeks 3.5 months postoperatively. Results: Pre‐ postoperative PFTs inversely...
Chronic noncancer pain includes a heterogenous group of disorders and is often refractory to treatment. Cannabis products have historically been used for chronic are attracting renewed pharmaceutical interest. Nabilone synthetic cannabinoid licensed in Canada the treatment severe nausea vomiting associated with cancer chemotherapy. We nabilone off-label since 1999. In this article, we review our clinical experience 20 adult patients who had treated followed up an average 1.5 years. Prior...
As pain is the cardinal symptom of fibromyalgia (FM), strategies directed towards relief are an integral component treatment. Opioid medications comprise a category pharmacologic treatments which have impact on in various conditions with best evidence for acute relief. Although opioid therapy other than tramadol has never been formally tested treatment FM, these agents commonly used by patients. We examined effect patients diagnosed FM and followed longitudinally multidisciplinary center...
Although persons with lower socioeconomic status (SES) generally have poorer health for many medical conditions, the association of SES symptom severity in fibromyalgia (FM) is unknown. The subjective symptoms FM may be influenced by personal perceptions, and environmental psychosocial factors. Therefore influence expression severity.Data this cross-sectional analysis were obtained from a real-life prospective cohort 246 patients categorized according to level education: high school...
Arthritis pain is reported as one of the most common reasons for persons using medical herbal cannabis in North America. "Severe arthritis" condition justifying legal use over half all authorizations Canada, where remains a controlled substance. As champions care with arthritis, rheumatologists must be knowledgeable treatment modalities both traditional and non-traditional, used by their patients. study cannabinoid molecules medicine recent, we have examined confidence knowledge cannabinoids...
The Quebec Pain Registry (QPR) is a large research database of patients suffering from various chronic pain (CP) syndromes who were referred to one five tertiary care centres in the province (Canada). Patients monitored using common demographics, identical clinical descriptors, and uniform validated outcomes. This paper describes development, implementation, potential QPR. Between 2008 2013, 6902 enrolled QPR, data collected prior their first visit at clinic six months later. More than 90%...
Alterations in the composition and function of gut microbiome women with fibromyalgia have recently been demonstrated, including changes relative abundance certain bile acid-metabolizing bacteria. Bile acids can affect multiple physiological processes, visceral pain, but yet to be explored for association microbiome. In this study, 16S rRNA sequencing targeted metabolomic approaches were used characterize circulating a cohort 42 healthy controls. several bacterial species known metabolize...