A5103182767- Pain Mechanisms and Treatments
- Musculoskeletal pain and rehabilitation
- Pain Management and Placebo Effect
- Pain Management and Opioid Use
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Pediatric Pain Management Techniques
- Cannabis and Cannabinoid Research
- Opioid Use Disorder Treatment
- Heat shock proteins research
- Effects of Radiation Exposure
- Botulinum Toxin and Related Neurological Disorders
- Radiation Therapy and Dosimetry
- Anesthesia and Pain Management
- Pharmacology and Obesity Treatment
- Forensic Toxicology and Drug Analysis
- Spine and Intervertebral Disc Pathology
- Complementary and Alternative Medicine Studies
- Myofascial pain diagnosis and treatment
- RNA modifications and cancer
- Cancer, Hypoxia, and Metabolism
- Treatment of Major Depression
- Poisoning and overdose treatments
- Pharmacological Effects and Assays
- Childhood Cancer Survivors' Quality of Life
- Cancer-related Molecular Pathways
Dalhousie University
2014-2024
Royal College of Physicians and Surgeons of Canada
2024
Harvard University
2023
Massachusetts General Hospital
2023
Cancer Research Center
2023
University of Washington
2021
Seattle Epidemiologic Information and Research Center
2021
Queen Elizabeth II Health Sciences Centre
2005-2020
Nova Scotia Health Authority
2018-2020
McGill University
2004-2015
Neuropathic pain (NeP), generated by disorders of the peripheral and central nervous system, can be particularly severe disabling. Prevalence estimates indicate that 2% to 3% population in developed world suffer from NeP, which suggests up one million Canadians have this disabling condition. Evidence‐based guidelines for pharmacological management NeP are therefore urgently needed. Randomized, controlled trials, systematic reviews existing focusing on were evaluated at a consensus meeting....
Eccleston, Christopher; Blyth, Fiona M.; Dear, Blake F.; Fisher, Emma A.; Keefe, Francis J.; Lynch, Mary E.; Palermo, Tonya Reid, M. Carrington; Williams, Amanda C de Author Information
Cannabis is widely used as a self-management strategy by patients with wide range of symptoms and diseases including chronic non-cancer pain. The safety cannabis use for medical purposes has not been systematically evaluated. We conducted prospective cohort study to describe issues among individuals A standardized herbal product (12.5% tetrahydrocannabinol) was dispensed eligible 1-year period; controls were pain from the same clinics who users. primary outcome consisted serious adverse...
The objective of the present study was to examine relative contributions different dimensions catastrophic thinking (i.e. rumination, magnification, helplessness) pain experience and disability associated with neuropathic pain. Eighty patients diabetic neuropathy, post-herpetic neuralgia, post-surgical or post-traumatic who had volunteered for participation in a clinical trial formed basis analyses. Spontaneous assessed sensory affective subscales McGill Pain Questionnaire. Pinprick...
OBJECTIVE: The present exploratory, descriptive study aimed to determine the designated time for mandatory pain content in curricula of major Canadian universities students health science and veterinary programs before being licensed. METHOD: Major university sites (n=10) were chosen where faculties included at least medicine nursing (n=10); many also dentistry (n=8), pharmacy (n=7), physical therapy (n=8) and/or occupational (n=6). These disciplines provide largest number entering workforce...
There has been a surge in interest medicinal cannabis Canada. We conducted questionnaire survey to determine the current prevalence of use among patients with chronic non-cancer pain, estimate dose size and frequency use, describe main symptoms for which relief was being sought. Over 6-week period mid-2001, 209 pain were recruited an anonymous cross-sectional survey. Seventy-two (35%) subjects reported ever having used cannabis. Thirty-two (15%) (pain users), 20 (10%) currently using relief....
To estimate the patterns and prevalence of cannabis use among patients with multiple sclerosis (MS), 220 were surveyed in Halifax, Nova Scotia. Seventy-two subjects (36%) reported ever having used for any purpose; 29 respondents (14%) continuing symptom treatment. Medical was associated male gender, tobacco use, recreational use. The symptoms by medical users to be most effectively relieved stress, sleep, mood, stiffness/spasm, pain.
A double-blind, randomized, placebo-controlled 3-week study evaluated the efficacy of topical 2% amitriptyline, 1% ketamine, and a combination both in treating patients with neuropathic pain.Ninety-two diabetic neuropathy, postherpetic neuralgia, or postsurgical/posttraumatic pain allodynia, hyperalgesia, pinprick hypesthesia were randomly assigned to receive one four creams (placebo, amitriptyline-1% ketamine combined). The primary outcome measure was change average daily intensity...
Fibromyalgia is difficult to treat and requires the use of multiple approaches. This study a randomized controlled trial qigong compared with wait-list control group in fibromyalgia.One hundred participants were randomly assigned immediate or delayed practice groups, receiving training at end period. Qigong (level 1 Chaoyi Fanhuan Qigong, CFQ), given over three half-days, was followed by weekly review/practice sessions for eight weeks; also asked home 45 60 minutes per day this interval....
The involvement of ongoing peripheral activity in the generation nociceptive input neuropathic pain suggests that topical drug delivery may be useful as a treatment strategy. This is pilot study providing initial information regarding use novel preparations containing amitriptyline (AMI), ketamine (KET), and combination both pain.The design included 2 day randomized, double blind, placebo controlled, 4 way cross-over trial all treatments, followed by an open label phase using cream for 7...
Previous research suggests that high levels of pain catastrophizing might predict poorer response to pharmacological interventions for neuropathic pain.The present study sought examine the clinical relevance relation between and analgesic in individuals with pain. Clinically meaningful reductions were defined terms magnitude through course treatment, number patients whose end-of-treatment ratings below 4⁄10.Patients (n=82) conditions completed a measure at beginning three-week trial...
Abstract Prenatal alcohol exposure (PAE) is associated with various adverse effects on human brain and behavior. Recently, neuroimaging studies have begun to identify PAE specific structures. Investigation of such important for understanding the teratogenic mechanism brain, which critical differentiating from other disorders. In this structural MRI study young adults, volumes automatically segmented cortical subcortical regions interest (ROIs) were evaluated both through a group difference...
Objectives: Several tools have been developed to screen for neuropathic pain. This study examined the sensitivity of Douleur Neuropathique en 4 Questions (DN4) in screening various pain syndromes. Materials and Methods: prospective observational was conducted 7 Canadian academic centers between April 2008 December 2011. All newly admitted patients (n=2199) were approached 789 eligible participants form sample this analysis. Baseline data included demographics, disability, health-related...
Background: As the result of public health authority responses to COVID-19 pandemic, pain clinics have had cease providing in-person appointments reduce contact between patients and staff. Over past decade, Canadians living with chronic faced long waiting times for care within multidisciplinary clinics. We are concerned that ceasing services exacerbates daily hardships already by pain.Aims: The aim this study was evaluate impact pandemic on Canadian clinics, their responses, changes clinic...