A5010911294- Malaria Research and Control
- Mosquito-borne diseases and control
- Synthesis and biological activity
- Synthesis and Characterization of Heterocyclic Compounds
- Dyeing and Modifying Textile Fibers
- Parasites and Host Interactions
- Synthesis of heterocyclic compounds
- Invertebrate Immune Response Mechanisms
- Synthesis of Organic Compounds
- Nanocomposite Films for Food Packaging
- Quinazolinone synthesis and applications
- Electrospun Nanofibers in Biomedical Applications
- HIV/AIDS drug development and treatment
- Endoplasmic Reticulum Stress and Disease
- Adsorption and biosorption for pollutant removal
- Advanced Cellulose Research Studies
- Synthesis and Biological Evaluation
- Neurological diseases and metabolism
- Drug Transport and Resistance Mechanisms
- Multicomponent Synthesis of Heterocycles
- Asymmetric Synthesis and Catalysis
- Trypanosoma species research and implications
- Autophagy in Disease and Therapy
- Synthesis and Reactions of Organic Compounds
- Enzyme-mediated dye degradation
Al Akhawayn University
2022-2024
Bezmiâlem Vakıf Üniversitesi
2019-2024
National Research Centre
2007-2023
Sanaria
2022
Tulane University
2014-2020
John F. Kennedy Medical Center
2018
Hackensack Meridian Health
2018
Center for Infectious Disease Research
2007-2011
King Saud bin Abdulaziz University for Health Sciences
2011
Heidelberg University
2005
Intracellular malaria parasites require lipids for growth and replication. They possess a prokaryotic type II fatty acid synthesis (FAS II) pathway that localizes to the apicoplast plastid organelle is assumed be necessary pathogenic blood stage However, importance of FAS throughout complex parasite life cycle remains unknown. We show in rodent model enzymes localize sporozoite liver apicoplast. Targeted deletion FabB/F, critical enzyme synthesis, did not affect replication, mosquito...
The Plasmodium life cycle is a sequence of alternating invasive and replicative stages within the vertebrate invertebrate hosts. How malarial parasites exit their host cells after completion reproduction remains largely unsolved. Inhibitor studies indicated role cysteine proteases in merozoite release from erythrocytes. To validate vital function active parasite egress, we searched for target genes that can be analyzed functionally by reverse genetics. Herein, describe complete arrest...
Falciparum malaria is initiated when Anopheles mosquitoes transmit the Plasmodium sporozoite stage during a blood meal. Irradiated sporozoites confer sterile protection against subsequent infection in animal models and humans. This level of unmatched by current recombinant vaccines. However, live-attenuated vaccine approach faces formidable obstacles, including development accurate, reproducible attenuation techniques. We tested whether falciparum could be attenuated at early liver genetic...
Malaria parasite sporozoites prepare for transmission to a mammalian host by upregulation of UIS (Upregulated in Infectious Sporozoites) genes. A number gene products are essential the establishment intrahepatocytic niche. However, factors that regulate expression genes involved gain infectivity liver unknown. Herein, we show conserved Plasmodium sporozoite low-complexity asparagine-rich protein, SAP1 (Sporozoite Asparagine-rich Protein 1), has an role malaria infection. Targeted deletion...
Abstract This review presents a systematic and comprehensive survey of the methods preparation benzofurans. These compounds are important intermediates for synthesis variety synthetically useful novel heterocyclic systems.
The malaria parasite sporozoite transmission stage develops and differentiates within oocysts on the Anopheles mosquito midgut. Successful inoculation of into a mammalian host is critically dependent sporozoite's ability to first infect salivary glands. Remarkable changes in tissue infection competence are observed as sporozoites transit from midgut Our microarray analysis shows that compared oocyst sporozoites, gland upregulate expression at least 124 unique genes. Conversely, show...
Repeated immunizations with whole Plasmodium blood stage parasites and concomitant drug cure of infection confer protective immunity against parasite challenge in mice, monkeys humans. Moreover, it was recently shown that infections genetically modified rodent malaria conferred sterile protection lethal challenge. However, these models vaccination resulted high parasitemias and, consequence, carries risk vaccine-induced pathology death. Herein, we generated a novel, completely...
Summary Plasmodium salivary gland sporozoites upregulate expression of a unique subset genes, collectively called the UIS (upregulated in infectious sporozoites). Many were shown to be essential for early liver stage development, although little is known about their regulation. We previously identified conserved sporozoite‐specific protein, SAP1, which has an role infection. Targeted deletion SAP1 yoelii caused depletion number selectively tested transcripts sporozoites, resulting complete...
In nearly all non-photosynthetic cells, pantothenate (vitamin B5) transport and utilization are prerequisites for the synthesis of universal essential cofactor Coenzyme A (CoA). Early studies showed that human malaria parasites rely on uptake across parasite plasma membrane survival within erythrocytes. Recently, a P. falciparum candidate transporter (PAT) was characterized by functional complementation in yeast. These revealed PfPAT mediated yeast cells low concentrations restored...
Textile wet processing is one of the most polluting industrial processes. It a complex process, and its complexity depends on composition textile material. From this point view, new efficient strategies for cotton are needed, which cost-effective reduce impact environment. The goal work to accomplish aspects preparatory finishing (desizing, scouring) by means "green chemistry," or, in other words, nontoxic enzymatic treatments. To achieve goal, mixture α-amylase (Am) polygalacturonase (PG)...
Upregulated in infectious sporozoites gene 4 (UIS4) encodes a parasitophorous vacuole membrane protein expressed the sporozoite and liver stages of rodent malaria parasites. Parasites that lack UIS4 arrest early liver-stage development, vaccination mice with uis4(-) confers sterile protection against challenge sporozoites. Currently, it remains unclear whether an ortholog is carried human parasite Plasmodium falciparum, although PF10_0164 has been identified as candidate for on basis synteny...