A5041104838- Cancer-related Molecular Pathways
- Ubiquitin and proteasome pathways
- CAR-T cell therapy research
- Lymphoma Diagnosis and Treatment
- Renal cell carcinoma treatment
- RNA modifications and cancer
- Forensic Toxicology and Drug Analysis
- Diverse Scientific Research Studies
- Cardiac, Anesthesia and Surgical Outcomes
- Chronic Lymphocytic Leukemia Research
- School Health and Nursing Education
- Alcohol Consumption and Health Effects
- Therapeutic Uses of Natural Elements
- Air Quality and Health Impacts
- Artificial Intelligence in Healthcare and Education
- Agriculture and Farm Safety
- Bladder and Urothelial Cancer Treatments
- Adipokines, Inflammation, and Metabolic Diseases
- Infective Endocarditis Diagnosis and Management
- HIV/AIDS drug development and treatment
- Cardiac Valve Diseases and Treatments
- Cancer Genomics and Diagnostics
- Heme Oxygenase-1 and Carbon Monoxide
- Air Quality Monitoring and Forecasting
- Cardiovascular Function and Risk Factors
Rajasthan Police Academy
2024
Yale University
2023-2024
Galgotias University
2024
Roswell Park Comprehensive Cancer Center
2018-2019
Abstract Background: Immune checkpoint inhibitors (ICI) have tremendously improved outcomes for various cancers but can be associated with immune-related adverse effects (IrAE), which affect multiple organ systems. For patients pre-existing autoimmune diseases (AD), there is an added risk of exacerbating autoimmunity, either through a flare prior IrAEs or the development de novo during ICI therapy. Clinical trials leading up to FDA approval ICIs excluded AD, resulting in lack data on...
Introduction: Renal cell carcinoma (RCC) with sarcomatoid component carries a poor prognosis. Immune checkpoint inhibitors (CPIs) have been approved for the treatment of metastatic RCC, but their efficacy in patients is not known.Materials and Methods: We conducted retrospective chart review 30 consecutive at our center who were treated RCC component.Results: Ten CPI group while 20 No-CPI group. There no significant differences age, sex, race, stage diagnosis between two groups. After median...
Alzheimer's disease is a progressive neurological condition characterized by brain changes resulting in the accumulation of specific proteins, leading to shrinkage and eventual cell death. It primary cause dementia, gradual decline memory, cognition, behaviour, social skills, impairing overall functionality. The case study involves an 84-year-old woman displaying symptoms requiring physiotherapy rehabilitation. Assessment reveals joint pain, abnormal gait, respiratory issues due pneumonia,...
Objectives: Tobacco consumption is mainly done in two forms, smoked tobacco and smokeless tobacco. This study was carried out to determine the negative effects of cigarette smoking, bidi chewing on haematological parameters establish a link between them. Material methods: A matched comparative cross-sectional Upgraded Department Physiology partnership with Medicine at SMS Medical College, Jaipur. The included 210 apparently healthy people (70 smokers, 70 chewers, non-tobacco users). Blood...
The incidence of cardiovascular disease is increasing in young adults. We are reporting a case acute stroke patient with severe ischaemic cardiomyopathy the absence traditional risk factors. After ruling out atherosclerotic disease, his presentation was attributed to synthetic cannabinoid use. then discussed typical barriers early diagnosis and limitations laboratory testing this condition. Due increase abuse these drugs among adults, there need for high clinical suspicion which can help...
Abstract Background: X-linked inhibitor of apoptosis protein (XIAP) has been implicated in development resistance to chemotherapy via its direct inhibition caspases 3,7 and 9. It is overexpressed several lymphoma cell lines including rituximab-resistant (RRCL), Raji4RH RL4RH, produced by our group. We have previously demonstrated that XIAP critical for chemotherapy-resistance survival RRCL knocking down using siRNA interference which chemotherapy-sensitivity RRCL. MDM2 activates p53...
Abstract Background: Upregulation of the anti-apoptotic protein Mcl-1 has been implicated in chemotherapy resistance and poor clinical outcomes activated B-cell like (ABC)-DLBCL. We hypothesized that singular inhibition by AMG-176 and/or dual MCL-1 Bcl-2 combining with venetoclax could be an effective strategy for inducing cell death DLBCL pre-clinical models. Materials Methods: Using a panel lines, we conducted targeting AMG-176. Cells were exposed to as single agent (0-20uM) over 24, 48,...