A5082230423- RNA Research and Splicing
- Cytokine Signaling Pathways and Interactions
- Cancer-related molecular mechanisms research
- interferon and immune responses
- Biofuel production and bioconversion
- Autophagy in Disease and Therapy
- Hematopoietic Stem Cell Transplantation
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Probiotics and Fermented Foods
- Energy and Environment Impacts
- Postharvest Quality and Shelf Life Management
- Advanced Glycation End Products research
- Food Safety and Hygiene
- RNA regulation and disease
- Listeria monocytogenes in Food Safety
- Blood transfusion and management
- Mycobacterium research and diagnosis
- RNA modifications and cancer
- Tuberculosis Research and Epidemiology
- Immune Response and Inflammation
- Xenotransplantation and immune response
- RNA and protein synthesis mechanisms
- Microbial Metabolites in Food Biotechnology
- Immune cells in cancer
Washington University in St. Louis
2020-2025
North Carolina State University
2008-2018
Agricultural Research Service
2008
RNA binding proteins are important regulators of T cell activation, proliferation, and cytokine production. The zinc finger protein 36 (ZFP36) family genes (
Abstract Better understanding of the host responses to Mycobacterium tuberculosis infections is required prevent and develop new therapeutic interventions. The transcription factor BHLHE40 essential for controlling M. infection, in part by repressing Il10 expression, where excess IL-10 contributes early susceptibility Bhlhe40−/− mice infection. Deletion Bhlhe40 lung macrophages dendritic cells sufficient increase but how impacts macrophage cell unknown. In this study, we report that myeloid...
Abstract TH17 cells are implicated in the pathogenesis of multiple sclerosis and experimental autoimmune encephalomyelitis (EAE). We previously reported that transcription factor basic helix-loop-helix family member e40 (BHLHE40) marks cytokine-producing pathogenic TH during EAE, its expression T is required for clinical disease. In this study, using dual reporter mice, we show BHLHE40 within TH1/17 ex-TH17 following EAE induction. Il17a-Cre–mediated deletion led to less severe with reduced...
Abstract The zinc finger 36 (ZFP36) family of RNA-binding proteins, consisting ZFP36, ZFP36L1, and ZFP36L2, is known to negatively regulate mRNA stability and/or inhibit translation many transcripts, including cytokines. While there are reports all three members regulating T cell cytokine production, delineating the functions these genes challenging due spontaneous phenotypes upon global deletion single potential redundancy in their functions. To overcome this, we generated Cd4-Cre+...
Abstract We currently lack a complete understanding of the immune responses required to control Mycobacterium tuberculosis (Mtb) infection. Our lab has shown that transcription factor BHLHE40 is essential during Mtb Deletion Bhlhe40 in CD11c +lung macrophages and dendritic cells (DCs) sufficient increase mouse susceptibility infection, though role these infection unknown. Murine bone marrow cultured presence GM-CSF, an abundant cytokine lung, develop into populations +macrophages, DCs,...
Abstract Cytokine production must be tightly regulated in order to prevent auto-inflammatory diseases. The zinc finger 36 (Zfp36) family of RNA-binding proteins, including Zfp36, Zfp36l1, and Zfp36l2, are known negatively regulate mRNA stability or translation many transcripts, cytokines. Polymorphisms ZFP36L1 ZFP36L2 have been identified GWAS studies a variety human autoimmune diseases, necessitating understanding the functions these genes. While there reports all three members controlling...
Abstract Cytokine production must be tightly regulated in order to prevent auto-inflammatory diseases. The zinc finger 36 (Zfp36) family of RNA-binding proteins, including Zfp36, Zfp36l1, and Zfp36l2, are known negatively regulate mRNA stability or translation many transcripts, cytokines. Polymorphisms ZFP36L1 ZFP36L2 have been identified GWAS studies a variety human autoimmune diseases, necessitating understanding their functions. While there reports all three members regulating T cell...