A5025983616- Hippo pathway signaling and YAP/TAZ
- Retinal and Macular Surgery
- Retinal and Optic Conditions
- Glaucoma and retinal disorders
- Visual perception and processing mechanisms
- Retinal Imaging and Analysis
- Genetic and Kidney Cyst Diseases
- Intraocular Surgery and Lenses
- Retinal Diseases and Treatments
- RNA Research and Splicing
- Optical Coherence Tomography Applications
- Microtubule and mitosis dynamics
- Virtual Reality Applications and Impacts
- Cancer-related molecular mechanisms research
- Advanced Optical Imaging Technologies
- Acute Ischemic Stroke Management
- Pregnancy and preeclampsia studies
- Melanoma and MAPK Pathways
- Ocular Infections and Treatments
- Musculoskeletal pain and rehabilitation
- Micro and Nano Robotics
- Advanced Glycation End Products research
- Scoliosis diagnosis and treatment
- Protist diversity and phylogeny
- Urological Disorders and Treatments
Washington University in St. Louis
2021-2022
Seoul National University
2009-2021
Seoul National University Bundang Hospital
2011-2021
Institute for Basic Science
2017
Korea Advanced Institute of Science and Technology
2012-2015
Angiogenesis is a multistep process that requires coordinated migration, proliferation, and junction formation of vascular endothelial cells (ECs) to form new vessel branches in response growth stimuli. Major intracellular signaling pathways regulate angiogenesis have been well elucidated, but key transcriptional regulators mediate these control EC behaviors are only beginning be understood. Here, we show YAP/TAZ, coactivator acts as an end effector Hippo signaling, critical for sprouting...
Primary cilia exert a profound impact on cell signalling and cycle progression. Recently, actin cytoskeleton destabilization has been recognized as dominant inducer of ciliogenesis, but the exact mechanisms regulating ciliogenesis remain poorly understood. Here we show that remodelling controls by transcriptional coactivator YAP/TAZ well ciliary vesicle trafficking. Cytoplasmic retention correlates with active either in spatially confined cells or treated an filament destabilizer. Moreover,...
RNA binding proteins are important regulators of T cell activation, proliferation, and cytokine production. The zinc finger protein 36 (ZFP36) family genes (
Objective evaluation results using optometric device to measure accommodative responses in viewing a real object and integral imaging are presented. From the empirical between an integrated three-dimensional (3D) image, we find that over 73% of participants keep eyes on 3D image instead display panel. The also show do not recognize mismatch response convergence eye, which used be believed as one major factors cause visual fatigue near-distance imaging. Seventy-one normal adult subjects (23 ~...
To analyze the long-term changes of peripapillary retinal nerve fiber layer (RNFL) thickness before and after panretinal photocoagulation (PRP) in patients with severe diabetic retinopathy.In this retrospective observational case series, we reviewed records 46 (68 eyes) retinopathy, who were treated PRP could be followed for more than 6 months. Peripapillary RNFL foveal measured at baseline, 3-month intervals until 1 year post-PRP, 6- to 12-month post-PRP using optical coherence tomography....
To investigate the validity and reliability of Microsoft Kinect-based head tracker (KHT) for measuring posture.Considering cervical range motion (CROM) as a reference, one-dimensional three-dimensional (1D 3D) postures 12 normal subjects (28-58 years age; 6 women men) were obtained using KHT. The KHT was validated by Pearson's correlation coefficient intraclass (ICC) coefficient. Test-retest determined its 95% limit agreement (LoA) with Bland-Altman plot. Face recognition success rate...
Purpose.: To evaluate the accuracy, validity, and reliability of a newly developed infrared optical head tracker (IOHT) using Nintendo Wii remote controllers (WiiMote; Co. Ltd., Kyoto, Japan) for measurement angle posture. Methods.: The IOHT consists two (IR) receivers (WiiMote) that are fixed to mechanical frame connected monitoring computer via Bluetooth communication channel an IR beacon four light-emitting diodes (LEDs). With use Cervical Range Motion (CROM; Performance Attainment...
A 68-year-old woman presented with a visual field defect in her right eye.The fundus of eye showed multiple telangiectatic vessels, retinal hemorrhages, and subretinal exudates the inferior peripheral retina.Nine months later, extended to fovea despite treatment laser photocoagulation.Cryotherapy was not possible at time because posterior location vessels.She treated combination photodynamic therapy (PDT) intravitreal bevacizumab injection: three injections were given 2-month intervals.After...
Central retinal artery occlusion (CRAO) is associated with and shares common risk factors cardiovascular diseases. Over the past several decades, incidence rates of stroke ischemic heart disease have substantially decreased in high-income industrialized countries. However, little known regarding current trends CRAO rates.To estimate Korea.This nationwide population-based cohort study was designed on September 7, 2017, used data from Korean National Health Insurance Service January 1, 2002,...
Accommodative response measurement according to angular resolution in autostereoscopic display based on lenticular lens and array method is presented. Conflict between accommodation convergence one of the most dominant factors leading visual fatigue viewing three-dimensional display. The conflict originates from directional rays that do not have enough density. Therefore purpose this paper verify relationship density elemental images accommodation-convergence conflict. For a single eye, we...
To investigate whether the parafoveal capillary architecture predicts clinical course and visual outcomes after epiretinal membrane (ERM) surgery.A total of 71 eyes patients treated with vitrectomy for idiopathic ERM were enrolled. The displacement fractal geometries compared according to stage ERM. Correlations between in superficial plexus, dimension lacunarity deep plexus (DCP), foveal thickness, evaluated.Compared mild ERM, severe exhibited higher lower DCP, greater thickness (P < 0.05)....
Central retinal artery occlusion (CRAO) is an ischemic stroke of the eye. The atherosclerotic lesions in intracranial segment carotid (CA) and ophthalmic (OphA) are not well defined. We aimed to investigate cerebral angiographic features CRAO patients assess relationship between outcomes after intra-arterial thrombolysis (IAT). included 101 acute non-arteritic treated with IAT. analyzed detailed OphA ipsilateral CA, visual acuity, fundus photography, fluorescein angiography. Of patients, 38...
Single umbilical artery (SUA) is the most common malformation of cord. However, there have been no studies on ocular findings in SUA, except for one case report. This study aimed to investigate children with SUA.Fourteen (eight boys and six girls) SUA were evaluated retrospectively. All underwent a complete ophthalmologic examination.The prevalence abnormal was up 42.9%. Refractive errors are detected four eyes (14.3%): myopia ≥-1.50 diopters (D) eye (3.6%) hyperopia ≥+2.00 D three (10.7%)....
Abstract The zinc finger 36 (ZFP36) family of RNA-binding proteins, consisting ZFP36, ZFP36L1, and ZFP36L2, is known to negatively regulate mRNA stability and/or inhibit translation many transcripts, including cytokines. While there are reports all three members regulating T cell cytokine production, delineating the functions these genes challenging due spontaneous phenotypes upon global deletion single potential redundancy in their functions. To overcome this, we generated Cd4-Cre+...
Purpose: To describe the clinical features and surgical outcomes of congenital cataracts in patients with oculocerebrorenal syndrome. Methods: We retrospectively analyzed age, sex, types cataracts, operation method time, perioperative visual acuity, postoperative intraocular pressure, associated ocular disease 10 (20 eyes) that had been diagnosed syndrome undergone cataract surgery a minimum follow-up period 1 year. Results: All were male bilateral detected on their first full ophthalmic...
안와 평활근종 1예김종신 1 ⋅김남주 1,2 서울대학교 의과대학 안과학교실 , 분당서울대학교병원 안과 목적: 안구 돌출로 내원한 평활근종의 증례를 경험하였기에 이에 보고하고자 한다.증례요약: 69세 여자가 3개월 전 발생한 좌안 내원하였다.우안 안압 17 mmHg, 23 mmHg이었고 상방 주시시 좌안의 하방편위가 있었으며 안저 검사에서 상이측에 망막 주름이 관찰되었다.Computed Tomography (CT) 좌측 주변 조직과 잘 분획된 직경 2.6 cm 크기의 조영 증강되는 고형 종괴가 관찰되었다.종괴는 근원추 밖에 위치하며 안구를 앞쪽으로 밀고 있는 양상이었다.전신 마취 하에 외측 절개술