A5101649286- Analytical Chemistry and Sensors
- CCD and CMOS Imaging Sensors
- Photonic and Optical Devices
- Photoreceptor and optogenetics research
- Neuroscience and Neural Engineering
- Advanced Optical Sensing Technologies
- Biosensors and Analytical Detection
- Electrochemical sensors and biosensors
- Advanced Memory and Neural Computing
- Molecular Sensors and Ion Detection
- Advanced Fiber Optic Sensors
- Neural dynamics and brain function
- Electrochemical Analysis and Applications
- Advanced Fluorescence Microscopy Techniques
- Advancements in PLL and VCO Technologies
- Diamond and Carbon-based Materials Research
- Plant nutrient uptake and metabolism
- Gas Sensing Nanomaterials and Sensors
- Spectroscopy and Laser Applications
- Semiconductor Lasers and Optical Devices
- Optical Coherence Tomography Applications
- Water Quality Monitoring and Analysis
- Advanced MEMS and NEMS Technologies
- Advanced Sensor and Energy Harvesting Materials
- Photoacoustic and Ultrasonic Imaging
Toyohashi University of Technology
2016-2024
Various biosensing platforms for real-time monitoring and mapping of chemical signals in neural networks have been developed based on CMOS process technology. Despite their achievements, however, there remains a demand an advanced method that can offer detailed insights into cellular functions with higher spatiotemporal resolution. Here, we present pH image sensor employs high-density array 256 × pixels readout circuitry designed fast operation. The sensor's characteristics, such as the...
Abstract Recent studies have shown that protons can function as neurotransmitters in cultured neurons. To further investigate regional and neural activity-dependent proton dynamics the brain, development of a device with both wide-area detectability high spatial-ltemporal resolution is necessary. Therefore, we develop an image sensor spatial-temporal specifically designed for measuring vivo. Here, demonstrate spatially deferent stimulation by visual induced distinct patterns changes cortex....
Abstract The improvement of a filter-less fluorescence sensor, by suppressing forward scattering in silicon surface planarization is presented. A microscope has been widely used biochemical fields. However, it difficult to miniaturize because optical filters and other parts are necessary. We previously developed sensor. separation ability excitation light the previous device was 550:1. It necessary improve ability. This study focuses on suppression forward-scattered incident silicon, through...
We developed a low-detection-limit filter-free fluorescence sensor by charge accumulation technique. For accumulation, floating diffusion amplifier (FDA), which included capacitor, transfer gate, and source follower circuit, was used. To integrate CMOS circuits with the sensor, we adopted triple-well process to isolate transistors from on single chip. detected 0.1 nW under illumination of excitation light 1.5 ms one order magnitude greater than that previous current detection sensor.
The use of conventionally developed pH image sensors under light irradiation is challenging owing to the strong influence signal contamination. Thus, this study a sensor that achieves measurement without We propose method separate and information by combining arraying two types pixels with different characteristics. A proof-of-concept was designed as 32 × 32-pixel sensor. characterization results fabricated demonstrated its capability simultaneously measure intensity error 10%. proposed...
In this study, we developed a filter-free fluorescence image sensor that performed 2D imaging without optical filters utilizing the wavelength-dependent absorption depth of silicon substrate. This changes potential distribution in direction substrate by controlling polysilicon gate atop sensing area. And it can display both images excitation light and at same time measuring each current. We obtained quantum dot emission immobilized on 32 × sensor. Quantum emitted with wavelength 620 nm...
Conventionally developed pH image sensors are strongly affected by light. In this study, we a multimodal sensor that can simultaneously measure light and visualize each separately. We propose method for sensing of combining arraying two types pixels with different characteristics. The results the characterization proof-of-concept device demonstrated it information measurement error 10% an optical 8%. proposed enables imaging under irradiation, whereas previously, was possible only dark...
In this paper, the detection of fluorescence from solution a fluorescent dye with submicromolar concentration by filter-free sensor is reported. The has photo-gate structure and intensities excitation lights can be calculated photocurrents for different gate voltages. It makes it possible to measure various wavelengths even without optical filters mirrors. separation ability light (470 nm) (530 in developed was 1200:1 LED source. measurements were carried out fluorescein isothiocyanate...
We developed a <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">$256\times 32$</tex> -pixel needle-type pH image sensor to visualize ion behavior at the cellular level under in vivo conditions. This has pixel configuration that can be fabricated via modified CMOS process technology, and it achieved size of xmlns:xlink="http://www.w3.org/1999/xlink">$5.65\times 4.39\ \mu \mathrm{m}^{2}$</tex> . The proposed is highest-definition implantable among...
We report the world-first result of visualization intra-stem ion dynamics living plants using a novel image sensor. A dedicated sensor that can insert to plant stem was fabricated. The has <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">$128\times 32$</tex> ion-sensitive pixels capture distribution reflecting structure (vascular bundle). Imaging results showed hydrogen ions moved from bottom top due natural transpiration. Ion vascular bundle...
Recently there has been a growing trend toward the development of touch sensing devices with high spatial resolution in robotic field. Most all sensors are limited due to their large device size. We have aimed develop high-density and high-resolution pressure sensor array using complementary metal oxide semiconductor (CMOS) imaging technologies. To realize device, we here propose bonding technique that connects polarized film 256 × potentiometric demonstrate fabricated device.
In this study, we designed and evaluated a new extended gate pH image sensor with accumulation function circuits as state-of-the-art bio-image sensor. The circuit can be expected to amplify the signal by repeatedly transferring charge from pixel capacitor, improve resolution viewpoint of noise ratio (SNR). From measurement results, achieved sensitivity 210 mV / 0.0099 at single four times accumulation. These results indicate future realization an capable imaging activity biological cells 0.01 pH.
In vivo neural imaging devices are developed not only to record chronically but also obtain the spatiotemporal information of neurochemical signals. Here, we present an image sensor consisting a 256 × pixel array and integrated readout circuitry for biomedical implantation application. The key idea this is that higher resolution than our previous insertable realizes by employing two transistors in circuit. proposed architecture was fabricated modified 1P4M 0.15 μm CMOS process. This able...
Ion measurements in existing ion sensors fluctuate significantly owing to the incident light. Therefore, a light shield is required, which critically limits applicability of sensors. In this study, two sophisticated methods eliminate optical signal contamination occurring during imaging were proposed and demonstrated. The first method involved design pixels with different characteristics, comparatively eliminated interference second measure voltage due photoelectrons subtracted it from...