A5026807326- Tuberculosis Research and Epidemiology
- Antibiotics Pharmacokinetics and Efficacy
- Pneumocystis jirovecii pneumonia detection and treatment
- Drug Transport and Resistance Mechanisms
- Antibiotic Use and Resistance
- Infectious Diseases and Tuberculosis
- Pneumonia and Respiratory Infections
- Epilepsy research and treatment
- Bacterial Identification and Susceptibility Testing
- Infective Endocarditis Diagnosis and Management
- Computational Drug Discovery Methods
- Metabolism and Genetic Disorders
- Bipolar Disorder and Treatment
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Coronary Artery Anomalies
- Mycobacterium research and diagnosis
- Anesthesia and Pain Management
- Nausea and vomiting management
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Healthcare Systems and Technology
- Antibiotic Resistance in Bacteria
- Cancer therapeutics and mechanisms
- Pharmacological Effects of Natural Compounds
- Pharmaceutical Practices and Patient Outcomes
- Rheumatoid Arthritis Research and Therapies
University of Maiduguri
2021-2023
University of Florida
2018-2023
Florida College
2023
Stellenbosch University
2016-2022
Columbus Oncology and Hematology Associates
2018-2020
Rationale: Carbapenems are recommended for treatment of drug-resistant tuberculosis. Optimal dosing remains uncertain. Objectives: To evaluate the 14-day bactericidal activity meropenem, at different doses, with or without rifampin. Methods: Individuals drug-sensitive pulmonary tuberculosis were randomized to one four intravenous meropenem-based arms: 2 g every 8 hours (TID) (arm C), TID plus rifampin 20 mg/kg once daily D), 1 E), 3 F). All participants received amoxicillin/clavulanate each...
Erector spinae plane blocks have become popular for thoracic surgery. Despite a theoretically favorable safety profile, intercostal spread occurs and systemic toxicity is possible. Pharmacokinetic data are needed to guide safe dosing.Fifteen patients undergoing surgery received continuous erector with ropivacaine 150 mg followed by subsequent boluses of 40 every 6 hours infusion 2 mg/hour. Arterial blood samples were obtained over 12 analyzed using non-linear mixed effects modeling, which...
Introduction: antibiotic overprescribing is associated with resistance worldwide but worst in developing nations. Minimal information exists on the prescribing habits of essentially all cadres healthcare workers Nigeria, particularly primary (PHC) workers. Our aim was to explore Nigerian context increasing which has a direct effect infections (HCAIs) and patient safety worldwide.
Abstract The glycopeptide antibiotic vancomycin is used for treatment of methicillin‐resistant Gram‐positive cocci. Adequate plasma concentrations are related to bacterial cure. However, inter‐ and intrapatient variability make it difficult achieve therapeutic concentrations. primary objective this study was determine the effectiveness using computerized drug monitoring (TDM) assist in achieving at a tertiary hospital South Africa. This 2‐period consisting retrospective 1‐month observational...
Abstract Background South Africa has one of the highest tuberculosis incidence rates. Biologic disease-modifying anti-rheumatic drugs are associated with an increased risk tuberculosis. The objective this study was to describe disease rate among public sector patients receiving biologic therapies in Western Cape Province. Methods A retrospective, descriptive analysis undertaken using routine health data collated by Provincial Health Data Centre from January 2007 (first use therapy Cape)...
Abstract Background Current TB treatment for children is not optimized to provide adequate drug levels in lesions. Dose optimization of first-line antituberculosis drugs increase exposure at the site disease could facilitate more optimal and future treatment-shortening strategies across spectrum with pulmonary TB. Objectives To determine concentrations intrathoracic Methods We quantified tissue samples from 13 children, median age 8.6 months, complicated forms requiring bronchoscopy or...
Abstract Para‐aminosalicylic acid (PAS), often the last drug remaining for treatment of drug‐resistant tuberculosis, is notorious causing gastrointestinal intolerance; however, cause PAS intolerance uncertain. The objective this study was to assess relationships between peak concentrations administered as a granular slow‐release enteric coated formulation, and its metabolites acetyl‐PAS glycine‐PAS, intolerance. were measured in 29 adult patients with tuberculosis at Brooklyn Hospital, Cape...
Background: Meropenem is being investigated for repurposing as an anti-tuberculosis drug. This study aimed to develop a meropenem population pharmacokinetics model in patients with pulmonary tuberculosis and identify covariates explaining inter-individual variability. Methods: Patients were randomized one of four treatment groups: 2 g three times daily plus oral rifampicin 20 mg/kg once daily, 1 3 daily. was administered by intravenous infusion over 0.5-1 h. All also received...
A 50-year-old woman known to have type 1 diabetes mellitus presented with a rare case of angio-oedema associated colistin use. The was temporally the use and discontinuation reasonable exclusion important differential diagnoses. Pseudoallergy may be probable underlying mechanism. However, we cannot exclude possibility hereditary 2 or 3, that her concomitant medications (particularly enalapril) renal impairment contributed risk severity angio-oedema.
Sinus of Valsalva Aneurysm (SVA) is a rare cardiac condition that commonly congenital.Acquired SVA very rare, resulting from infections affecting the aortic wall, degenerative diseases or traumatic injury to chest.Left SVAs are usually acquired, especially when associated with rupture into left heart.We present case ruptured in female Nigerian Septuagenarian who presented congestive failure.
Abstract Background Intravenous phenobarbital remains the first-line therapy in management of neonatal seizures. Shortages intravenous South Africa necessitated addition oral levetiracetam as part Objective We evaluated pharmacokinetics crushed immediate-release tablets administered to neonates terminate Methods A prospective, observational study admitted with seizures Tygerberg Hospital. Participants received (diluted saline) given orally or via naso-/orogastric tube. At steady-state,...
One of the greatest successes in fight against infectious diseases is discovery antimicrobials. This has remained a cornerstone subsequent advancements healthcare delivery. However, emergence Antimicrobial Resistance (AMR) dampened celebrations. Currently, AMR major hindrance to patient safety because emergence, re-emergence and continued spread multidrug resistant (MDR) pathogens. The speed extent threat human health globally. Several efforts approaches have been tried at different levels...