A5091773159- PI3K/AKT/mTOR signaling in cancer
- Metabolism, Diabetes, and Cancer
- Cancer Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Pancreatic function and diabetes
- interferon and immune responses
- Hedgehog Signaling Pathway Studies
- Cancer Cells and Metastasis
- Adrenal and Paraganglionic Tumors
- Colorectal Cancer Treatments and Studies
- Genetic factors in colorectal cancer
- Melanoma and MAPK Pathways
- Cancer Immunotherapy and Biomarkers
- Autophagy in Disease and Therapy
- Cytokine Signaling Pathways and Interactions
Univerzitetski Klinički Centar Srbije
2025
University of Belgrade
2021-2024
Centre Méditerranéen de Médecine Moléculaire
2014
Inserm
2010-2014
Université Côte d'Azur
2014
Metformin is the most widely used antidiabetic drug because of its proven efficacy and limited secondary effects. Interestingly, recent studies have reported that metformin can block growth different tumor types. Here, we show exerts antiproliferative effects on melanoma cells, whereas normal human melanocytes are resistant to these metformin-induced To better understand basis this effect in melanoma, characterized sequence events underlying action. We showed 24 h treatment induced a cell...
Introduction. Familial adenomatous polyposis is an autosomal dominant disorder characterized by the presence of 100 or more polyps in mucosal lining large intestine with a significant risk colorectal cancer development. Case outline. This article presents case report previously undiagnosed familial patient admitted to surgical emergency department suspected sigmoid carcinoma. On computed tomography (CT), findings colonic mucosa were inconclusive due inadequate distension bowel lumen and...
Breast cancer is the most commonly occurring malignancy and leading cause of cancer-related death in women. Triple-negative breast (TNBC) aggressive subtype associated with high recurrence rates, incidence distant metastases, poor overall survival. The aim this study was to investigate PI3K/PTEN/Akt/mTOR pathway as one frequently deregulated pathways cancer. We aimed explore impact PI3K mTOR oncogenes well PTEN tumor suppressor on TNBC clinical behavior, prognosis, multidrug resistance...
Triple-negative breast cancer (TNBC) is the most aggressive subtype and associated with high recurrence rates, a incidence of distant metastases poor overall survival. The aim this study was to investigate role PD-L1, EGFR AR expression in TNBC promotion progression. To that end, we analyzed immunohistochemical these genes 125 patients their relation clinicopathological parameters An elevated PD-L1 significantly correlated higher tumor nuclear grade, while low loco-regional without any...
<p><strong>Introduction.</strong> Breast cancer (BC) is the most frequent type of malignancy and leading cause related death among women worldwide. BC exceptionally heterogeneous disease therefore distinct treatment modalities are necessary to address these differences. The aim our study was investigate impact TP53 PTEN tumor suppressor genes (TSGs) inactivation on response different their possible cooperation, post-operative...