A5083208432- Cancer Genomics and Diagnostics
- Lung Cancer Treatments and Mutations
- Economic and Financial Impacts of Cancer
- Colorectal Cancer Treatments and Studies
- Behavioral Health and Interventions
- Gastric Cancer Management and Outcomes
- Radiomics and Machine Learning in Medical Imaging
- Esophageal Cancer Research and Treatment
- Health Systems, Economic Evaluations, Quality of Life
- Mobile Health and mHealth Applications
- Consumer Behavior in Brand Consumption and Identification
- Media Influence and Health
- Smoking Behavior and Cessation
- Obesity, Physical Activity, Diet
- Global Cancer Incidence and Screening
- Cancer Treatment and Pharmacology
- Cancer Immunotherapy and Biomarkers
- Child Development and Digital Technology
- Healthcare Policy and Management
- Genetic factors in colorectal cancer
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Lymphoma Diagnosis and Treatment
- Statistical Methods in Clinical Trials
- Impact of Technology on Adolescents
- Global Maternal and Child Health
Flatiron Health (United States)
2018-2025
Cancer Research Center
2017-2022
Fred Hutch Cancer Center
2017-2020
University of Washington
2012-2019
Bayer (United States)
2018
George Washington University
2011-2014
Seattle University
2012
Schulman, Ronca & Bucuvalas
2011
Abt Associates (Nepal)
2011
Abt Global (United States)
2011
Mobile phone technologies for health promotion and disease prevention have evolved rapidly, but few studies tested the efficacy of mobile in full-fledged programs. Text4baby is an example based on behavioral theory, it delivers text messages to traditionally underserved pregnant women new mothers change their health, care beliefs, practices, behaviors order improve clinical outcomes. The purpose this pilot evaluation study assess messaging campaign.We conducted a randomized study. All...
Abstract Background Lower neighborhood socioeconomic status (SES) is associated with suboptimal cancer care and reduced survival. Most studies examining inequities across area-level tend to use less granular or unidimensional measures pre-date the COVID-19 pandemic. Here, we examined association of on real-world treatment initiation overall survival among adults 20 common cancers. Methods This retrospective cohort study used electronic health record–derived deidentified data (Flatiron Health...
Background There is uncertainty around clinical applicability of tumor mutational burden (TMB) across cancer types, in part because inconsistency between TMB measurements from different platforms. The KEYNOTE 158 trial supported United States Food and Drug Administration (FDA) approval the Foundation Medicine test (FoundationOneCDx) at TMB≥10 mut/Mb as a companion diagnostic (CDx) for single-agent pembrolizumab second+line. Using large real-world dataset with validated survival endpoint...
Abstract Objective The present study examined whether characteristics such as quality, selection and convenience are associated with dietary intake of fruits vegetables independent perceived costs in an inner-city, low-income population. Design Secondary analysis baseline data from a social marketing intervention designed to change household practices among parents 3- 7-year-old children. Setting A community sample drawn six low-income, primarily minority neighbourhoods Chicago, IL, USA....
Background: Mobile health (mHealth) is growing rapidly, but more studies are needed on how to optimize programs, including optimal timing of messaging, dose exposure, and value interactive features. This study evaluates final outcomes text4baby (a text message service for pregnant postpartum women) from a randomized trial performed in population female soldiers family members. Objective: The aims were evaluate (1) treatment effects (2) dose-response behavioral compared control (no text4baby)...
Background: The use of mobile phone technologies for health promotion and disease prevention has advanced rapidly in recent years. Text4baby is a theory-based (mHealth) program which text messages are delivered to pregnant women new mothers improve their care beliefs behaviors status clinical outcomes. Recent evaluations have found that it improves targeted attitudes beliefs, but effects on behavior not yet been determined. Objective: In this study, investigators aimed evaluate the military...
Purpose The overall goal of the Saleema Initiative in Sudan is to promote long-term abandonment female genital mutilation and cutting (FGM) through a contribution changing social norms, attitudes, intentions related practice. initiative aims create positive cultural associations with girl remaining uncut, new norm. hypothesizes that branding alternative FGM (abandonment) will norms change. In 2014, lead author designed monitoring evaluation framework for partnership UNICEF, National Council...
Neurotrophic tyrosine receptor kinase (NTRK) gene fusions are oncogenic drivers in various tumor types. While NTRK predictive of benefit from tropomyosin inhibitors regardless type, the prognostic significance a pan-tumor setting remains unclear.This study evaluated characteristics and prognosis fusion cancer real-world setting.This retrospective used de-identified clinico-genomic database included patients with who had comprehensive genomic profiling between January 2011 July 2018. Patients...
2503 Background: There is controversy around the applicability of TMB across cancer types and reliability between assays from different manufacturers. The KEYNOTE 158 trial supported FDA approval Foundation Medicine test (FoundationOne CDx) at ≥ 10 mut/Mb as a solid tumor companion diagnostic (CDx) for single-agent pembrolizumab in 2 nd + line. Using large real-world dataset with validated rwOS endpoint data, we evaluated clinical validity measurement by approved over 8,000 patients 24 who...
ObjectivesLiquid biopsy and comprehensive genomic profiling (CGP) of circulating tumor DNA (ctDNA) are increasingly used for detection targetable alterations (GA) in non-small cell lung cancer (NSCLC). To examine the clinical outcomes patients following CGP using liquid versus tissue biopsy, receipt matched targeted therapy post-CGP associated were evaluated real-world setting.Methods6491 with NSCLC (N = 937 tests) and/or 5582 included a de-identified commercial clinico-genomic database....
Abstract Background The Flatiron Health-Foundation Medicine Clinico-Genomic Databases (CGDBs) are de-identified, real-world data sources that link comprehensive genomic profiling (CGP) with clinical derived from electronic health records (EHRs) for patients cancer. Comparing the CGDBs to US population of cancer allows researchers understand representativeness a cohort when designing, conducting, and interpreting their analyses. objective this study was compare demographic characteristics in...
The present study provides evidence to support enhanced attention reproductive health and comprehensive measures increase access quality services. We compare contrast the financing utilization of services in six sub-Saharan African countries using data from National Health Accounts Demographic Surveys. Spending on 2006 ranged US$4 per woman age Ethiopia US$17 Uganda. These are below necessary level for assuring adequate given that an internationally recommended spending family planning alone...
Background Adolescent substance use rates in rural areas of the United States, such as upstate New York, have risen substantially recent years, calling for new intervention approaches response to this trend. The Mentor Foundation USA conducts Living Example (LTE) campaign engage youth prevention using an experiential approach. As part LTE, create their own messages following a training curriculum techniques effective messaging and then share them via social media. This paper reports on pilot...
Zimbabwe suffers from one of the greatest burdens HIV/AIDS in world that has been compounded by social and economic instability past decade. However, 2001 to 2009 HIV prevalence among 15-49 year olds declined 26% approximately 14%. Behavior change condom use may part explain this decline. PSI-Zimbabwe socially markets Protector Plus (P+) branded line condoms. When converted a dollar-based economy 2009, price condoms was greatly increased new marketing efforts were undertaken. This paper...
Human epidermal growth factor receptor 2 (HER2) overexpression or amplification (ERBB2amp) are biomarkers for approved anti-HER2 therapies. ERBB2amp may better predict response compared with immunohistochemistry in situ hybridization, and quantitative copy number (CN) further stratify patients. We characterized advanced gastroesophageal adenocarcinomas (GEA) hypothesized that increased CN was associated outcome to trastuzumab.Comprehensive genomic profiling, including assessment of ERBB2amp,...
Since 2000, the truth campaign has grown as a social marketing brand. Back then, employed branding to compete directly with tobacco industry. In 2014, launch of FinishIt reflected changes in brand's strategy, control environment, and youth/young adult behavior. Building on previous validation study, current study examined brand equity FinishIt, measured by validated multi-dimensional scales, related attitudes, beliefs, behavior based two waves Truth Longitudinal Cohort data from 2015 2016. A...
Abstract Health brands are based on the relations between individuals and health behaviors lifestyles. Brands can be measured by brand equity construct validated in previous studies. The National Youth Anti-Drug Media Campaign alternative, non–drug use as a behavior change strategy. This study goes beyond campaign evaluations, which did not include specific measurements. Using data from nationally representative media tracking, this examined relation antidrug adoption of targeted attitudes,...
The original truth campaign was a branded, national smoking prevention mass media effort focused on at-risk youth ages 12–17. Today the brand focuses goal of finishing tobacco (truth FinishIt). There have been significant changes in control landscape, leading FinishIt to focus 15- 21-year-olds. present article reports formative research and monitoring data collected pilot test new equity scale. goals this study were (a) content analyze ads, (b) assess truth's social followers' perceptions...
Aim: To assess concordance between HER2 status measured by traditional methods and ERBB2 amplification next-generation sequencing its association with first-line trastuzumab clinical benefit in patients advanced esophagogastric cancer. Methods: Retrospective analysis of HER2/ERBB2 using a deidentified USA-based clinicogenomic database. Clinical outcomes were assessed for HER2+ cancer who received trastuzumab. Results: Overall was 87.5%. Among trastuzumab, concordant associated longer time to...
The Patient Protection and Affordable Care Act (ACA) addresses use of clinical preventive services relative to evidence-based guidelines by mandating that most health insurance plans provide coverage without cost-sharing for receive an A or B rating. However, knowledge about positive attitudes towards are extremely low. This study was a population-based randomized experiment examine beliefs intentions adhere screening the Prostate Specific Antigen (PSA) Pap tests. had two objectives: (1)...
Abstract Background RAS short variant (SV) mutations in colorectal cancer (CRC) are associated with lack of benefit from epidermal growth factor receptor (EGFR) monoclonal antibody (EGFRmAb). However, the clinical implications for amplification (RASa) as a biomarker anti-EGFR therapy CRC remain ill defined. Methods Genomic analysis was performed using Foundation Medicine (FM) comprehensive genomic profiling database 37,233 cases. Clinical outcomes were assessed two independent cohorts: City...