A5057995753- 3D Printing in Biomedical Research
- Liver physiology and pathology
- Erythrocyte Function and Pathophysiology
- Blood transfusion and management
- Gold and Silver Nanoparticles Synthesis and Applications
- Innovative Microfluidic and Catalytic Techniques Innovation
- Wireless Body Area Networks
- Neuroscience and Neural Engineering
- Tissue Engineering and Regenerative Medicine
- Hemoglobin structure and function
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Monoclonal and Polyclonal Antibodies Research
- Pluripotent Stem Cells Research
Emulate (United States)
2018-2019
University of Pennsylvania
2014-2017
A rat, dog, and human Liver-Chip designed using microengineered Organs-on-Chips technology recapitulates species-specific drug toxicities.
Clinical development of Hu5c8, a monoclonal antibody against CD40L intended for treatment autoimmune disorders, was terminated due to unexpected thrombotic complications. These life‐threatening side effects were not discovered during preclinical testing the lack predictive models. In present study, we describe microengineered system lined by human endothelium perfused with whole blood, “Vessel‐Chip.” The Vessel‐Chip allowed us evaluate key parameters in thrombosis, such as endothelial...
Red blood cell (RBC) transfusions are associated with increased risk of acute respiratory distress syndrome (ARDS) in the critically ill, yet mechanisms for enhanced susceptibility to ARDS conferred by RBC remain unknown.To determine lung endothelial (EC) High Mobility Group Box 1 (HMGB1) release following exposure RBCs and whether transfusion increases inflammation vivo through danger signal HMGB1.In vitro studies examining human EC viability HMGB1 allogenic were conducted under static...
Red blood cell (RBC) transfusion poses significant risks to critically ill patients by increasing their susceptibility acute respiratory distress syndrome. While the underlying mechanisms of this life-threatening syndrome remain elusive, studies suggest that RBC-induced microvascular injury in distal lung plays a central role development following transfusion. Here we present novel microengineering strategy model and investigate key disease process. Specifically, created microdevice for...
Abstract Nonclinical rodent and non-rodent toxicity models used to support clinical trials of candidate drugs may produce discordant results or fail predict complications in humans contributing drug failures the clinic. Here we applied microengineered Organ-on-Chip (Organ-Chip) technology design rat, dog, human Liver-Chips containing species-specific primary hepatocytes interfaced with liver sinusoidal endothelial cells, without Kupffer cells hepatic stellate cultured under physiological...