A5012866538- Immune Response and Inflammation
- Cancer Treatment and Pharmacology
- Chemotherapy-induced cardiotoxicity and mitigation
- Cytokine Signaling Pathways and Interactions
- Inflammatory Bowel Disease
- Chemotherapy-induced organ toxicity mitigation
- Sepsis Diagnosis and Treatment
- Parkinson's Disease Mechanisms and Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Cancer, Hypoxia, and Metabolism
- Genomics, phytochemicals, and oxidative stress
- Respiratory Support and Mechanisms
- Nerve injury and regeneration
- Clostridium difficile and Clostridium perfringens research
- Venous Thromboembolism Diagnosis and Management
- Mesenchymal stem cell research
- Enzyme function and inhibition
- Antimicrobial Resistance in Staphylococcus
- Clinical Nutrition and Gastroenterology
- Bacterial biofilms and quorum sensing
- Medical Imaging and Pathology Studies
- Biomarkers in Disease Mechanisms
- NF-κB Signaling Pathways
- Nanocomposite Films for Food Packaging
Suez Canal University
2014-2025
University of Toyama
2018-2020
Injury of a peripheral nerve (PNI) leads to both ischemic and inflammatory alterations. Sciatic injury (SNI) represents the most widely used model for PNI. Mesenchymal stem cell-based therapy (MSCs) has convenient properties on PNI by stimulating regeneration. Melatonin cytoprotective activity. The neuroprotective characteristics MSCs melatonin separately or in combination remain knowledge need. In rats-challenged SNI, therapeutic roles intralesional intraperitoneal injections were evaluated...
Doxorubicin (DOX) is used in the treatment of cancer. However, cardiotoxicity its major dose-limiting factor. Mechanism DOX–cardiac toxicity not completely elucidated. The aim current study was to explore whether addition subeffective dose curcumin (100 mg/kg) nebivolol would produce a better impact treating DOX-induced cardiac comparison with monotherapy. Male rats were and subdivided into seven groups. Cardiac induced 6 groups by intraperitoneal injection DOX over 23 days; six groups, five...
Ulcerative colitis (UC), a chronic autoimmune disease of the gut with relapsing and remitting nature, considers major health-care problem. DSS is well-studied pharmacologically-induced model for UC. Toll-Like Receptor 4 (TLR4) its close association p-38-Mitogen-Activated Protein Kinase (p-38 MAPK) nuclear factor kappa B (NF-κB) has important regulatory roles in inflammation developing Probiotics are gaining popularity their potential UC therapy. The immunomodulatory anti-inflammatory role...
Introduction: Although fluoroquinolones are used to treat methicillin-resistant Staphylococcus aureus (MRSA)-induced infections, acquisition of antibiotic resistance by bacteria has impaired their clinical relevance. We aimed evaluate the frequency norA, norB, and norC efflux pump genes-mediating measure expression levels in MRSA isolates. Methodology: 126 S. isolates were collected from different samples adult hospitalized patients identified conventional microbiological methods. was...
Abstract Sepsis is a major clinical challenge with unacceptably high mortality. The signal transducers and activators of transcription (STAT) family factors known to activate critical mediators cytokine responses, and, among this family, STAT3 implicated be key factor in both immunity inflammatory pathways. We investigated whether vivo introduction synthetic double-stranded decoy oligodeoxynucleotides (ODNs) can provide benefits for reducing organ injury mortality mice cecal ligation...
The recent global trend aims to limit the use of chemicals in all aspects our lives, necessitating research into plant extracts and ultraviolet light as eco-friendly treatments improve mango fruit storage. literature did not introduce studies on coating materials for Although ginger, lemon, green tea were utilized individually edible coatings some fruits, their combination a single solution is evaluated fruits. To preserve quality Keitt against decay during storage, fruits treated with (a...
STAT3 serves as a key transcription factor in both immunity and inflammatory pathways. We examined whether vivo introduction of decoy oligodeoxynucleotides (ODNs) is beneficial reducing septic end‐organ injury. Polymicrobial sepsis was induced by cecal ligation puncture (CLP) mice. rapidly activated major tissues following CLP, which accompanied activation the upstream kinase JAK2. Transfection ODNs significantly improved histopathological changes lung, liver, kidney, heart tissues. ODN...
Despite considerable progress in various antibiotic therapies, sepsis still has a high mortality rate. Sepsis been now redefined as life-threatening organ dysfunction due to dysregulated response of the host infection. Any definitive treatment for not yet established, and elucidation molecular mechanism pathology is an urgent issue. STAT3 (signal transducers activator transcription 3) inducible factor activated by cytokines such IL-6 regulates expression many genes involved immune...
Acute lung injury is one of the common lethal complications in sepsis.It clinically characterized by refractory hypoxemia, diffuse pulmonary infiltrates, and high permeability edema.Several molecules could contribute to increased vascular during sepsis.In this study, we investigated whether VEGF, originally known as a factor, plays possible role sepsis-associated hyperpermeability.Initially, examined time-dependent expression VEGF its receptors, Flt1 KDR, human endothelial cells...