Nicola S. Klein

ORCID: 0000-0002-2135-2123
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About
Contact & Profiles
Research Areas
  • Mental Health Research Topics
  • Treatment of Major Depression
  • Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
  • Mental Health Treatment and Access
  • Digital Mental Health Interventions
  • Tryptophan and brain disorders
  • Identity, Memory, and Therapy
  • Mind wandering and attention
  • Health Systems, Economic Evaluations, Quality of Life
  • Child and Adolescent Psychosocial and Emotional Development
  • Bipolar Disorder and Treatment
  • Aging and Gerontology Research
  • Attention Deficit Hyperactivity Disorder
  • Impact of Technology on Adolescents
  • Functional Brain Connectivity Studies

GGZ Drenthe
2018-2025

University of Groningen
2017-2019

University of Washington
2017

Columbia University
2017

Massachusetts General Hospital
2017

Harvard University
2017

Dalhousie University
2017

Abstract Major depressive disorder is a leading cause of disability worldwide; identifying effective strategies to prevent depression relapse crucial. This individual participant data meta-analysis addresses whether and for whom psychological interventions can be recommended prevention major disorder. One- two-stage patient meta-analyses were conducted on 14 randomized controlled trials ( N = 1,720). The risk over 12 months was substantially lower those who received intervention versus...

10.1038/s44220-023-00178-x article EN cc-by Nature Mental Health 2024-01-08

Background: Major depressive disorder (MDD) is highly recurrent and has a significant disease burden. Although the effectiveness of internet-based interventions been established for treatment acute MDD, little known about their cost effectiveness, especially in MDD. Objectives: Our aim was to evaluate utility an relapse prevention program (mobile cognitive therapy, M-CT). Methods: The economic evaluation performed alongside single-blind parallel group randomized controlled trial....

10.2196/10437 article EN cc-by Journal of Medical Internet Research 2018-10-18

Previously depressed individuals experience disturbances in affect. Affective may be related to visual mental imagery, given that imagery-based processing of emotional stimuli causes stronger affective responses than verbal experimental laboratory studies. However, the role everyday life is unknown. This study assessed imagery daily previously and never individuals. Higher levels was hypothesised associated with more reactivity both negatively positively valenced representations.This first...

10.1080/02699931.2017.1365047 article EN cc-by-nc-nd Cognition & Emotion 2017-08-17

Background Continuation of antidepressant medication (ADM) after remission is widely used to prevent depressive relapse/recurrence. Little known about predictors ADM use in terms adherence, dosage, and successful tapering. The current study aimed explore beliefs the causes depression recovery (i.e., causal beliefs) examine whether they predict use. Methods data were drawn from a controlled trial an extension this with additional experience sampling. In total, 289 remitted patients recurrent...

10.1002/da.22598 article EN Depression and Anxiety 2017-01-19

Relapse prevention strategies include continuation of antidepressant medication and preventive psychological interventions. This study aims to gain understanding that may inform tailoring relapse individual differences, improve their effects. Such treatment personalization be based on repeated assessments within one individual, using experience sampling methodology. As a first step towards informing decisions this methodology, insight is needed in differences risk response treatment, how...

10.1016/j.conctc.2017.07.003 article EN cc-by-nc-nd Contemporary Clinical Trials Communications 2017-07-12

Background As depression has a recurrent course, relapse and recurrence prevention is essential. Aims In our randomised controlled trial (registered with the Nederlands register, identifier: NTR1907), we found that adding preventive cognitive therapy (PCT) to maintenance antidepressants (PCT+AD) yielded substantial protective effects versus only in individuals depression. Antidepressants were not superior PCT while tapering (PCT/−AD). To inform decision-makers on treatment allocation,...

10.1192/bjo.2018.81 article EN cc-by-nc-nd BJPsych Open 2019-01-01

BackgroundThere is an urgent need to better understand and prevent relapse in major depressive disorder (MDD). We explored the differential impact of various MDD prevention strategies (pharmacological and/or psychological) on affect fluctuations individual networks a randomised setting, their predictive value for relapse.MethodsWe did secondary analysis using experience sampling methodology (ESM) data from individuals with remitted recurrent depression that was collected alongside controlled...

10.1016/j.eclinm.2023.102329 article EN cc-by EClinicalMedicine 2023-11-22

<sec> <title>BACKGROUND</title> Major depressive disorder (MDD) is highly recurrent and has a significant disease burden. Although the effectiveness of internet-based interventions been established for treatment acute MDD, little known about their cost effectiveness, especially in MDD. </sec> <title>OBJECTIVES</title> Our aim was to evaluate utility an relapse prevention program (mobile cognitive therapy, M-CT). <title>METHODS</title> The economic evaluation performed alongside single-blind...

10.2196/preprints.10437 preprint EN 2018-03-23
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