A5109139968- Air Quality and Health Impacts
- Toxic Organic Pollutants Impact
- Mercury impact and mitigation studies
- Heavy Metal Exposure and Toxicity
- Effects and risks of endocrine disrupting chemicals
- Occupational and environmental lung diseases
- Environmental Justice and Health Disparities
- Carcinogens and Genotoxicity Assessment
- Occupational exposure and asthma
- Climate Change and Health Impacts
- Injury Epidemiology and Prevention
- Indoor Air Quality and Microbial Exposure
- Agriculture and Farm Safety
- Hearing, Cochlea, Tinnitus, Genetics
- Law and Political Science
- Public Administration and Political Analysis
- Occupational Health and Safety Research
- Noise Effects and Management
- Immunotoxicology and immune responses
- Hearing Loss and Rehabilitation
- Per- and polyfluoroalkyl substances research
- Neonatal Health and Biochemistry
- Public Health Policies and Education
- Food Security and Health in Diverse Populations
- Health, Environment, Cognitive Aging
University of Wisconsin–Madison
1992-2024
Cardiff and Vale University Health Board
2024
University of Wisconsin Health
2017-2020
Wisconsin Department of Health Services
2008-2019
Anderson University - South Carolina
2005-2018
Christensen Fund
2018
Wellcome / EPSRC Centre for Interventional and Surgical Sciences
2018
Wisconsin Division of Public Health
2007-2016
Centers for Disease Control and Prevention
1997-2016
Milwaukee Health Department
2002-2016
With the release of landmark report Toxicity Testing in 21st Century: A Vision and a Strategy, U.S. National Academy Sciences, 2007, precipitated major change way toxicity testing is conducted. It envisions increased efficiency decreased animal usage by transitioning from current expensive lengthy vivo with qualitative endpoints to vitro pathway assays on human cells or cell lines using robotic high-throughput screening mechanistic quantitative parameters. Risk assessment exposed population...
The use of nitrate-contaminated drinking water to prepare infant formula is a well-known risk factor for methemoglobinemia. Affected infants develop peculiar blue-gray skin color and may become irritable or lethargic, depending on the severity their condition. condition can progress rapidly cause coma death if it not recognized treated appropriately. Two cases blue baby syndrome were recently investigated. Both involved who became ill after being fed that was reconstituted with from private...
Persistent pollutants, such as polychlorinated biphenyls (PCBs), affect endocrine function. Human exposure to polybrominated diphenyl ethers (PBDEs), which are similar in structure PCBs, has increased recently, but health effects have not been well studied.Our goal this study was determine whether PBDE body burdens related thyroid and steroid hormone levels, antibodies, disease a cohort of frequent infrequent adult male sport fish consumers.We tested serum from 405 males for congeners, PCB...
BackgroundStudies have demonstrated ubiquitous human exposure to persistent organic pollutants (POPs) such as p,p′-diphenyldichloroethene (DDE) and polychlorinated biphenyls (PCBs). Although there is considerable evidence that POP exposures are associated with prevalent diabetes, these studies do not establish causality because the cross-sectional study design does allow for assessment of temporality exposure–disease association. Prospective studies, however, been lacking.ObjectivesThis was...
Inorganic arsenic is naturally occurring in groundwaters throughout the United States. This study investigated exposure and self-report of 9 chronic diseases. We received private well-water samples questionnaires from 1185 people who reported drinking their water for 20 or more years. Respondents with levels 2 microg/L greater were statistically likely to report a history depression, high blood pressure, circulatory problems, bypass surgery than respondents concentrations less microg/L.
Objectives. This study examined whether differences in heat alone, as opposed to public health interventions or other factors, accounted for the reduction heat-related deaths and paramedic emergency medical service (EMS) runs between 1995 1999 during 2 waves occurring Milwaukee, Wis. Methods. Two previously described prediction models were adapted compare expected observed morbidity mortality based on city's experience. Results. Both showed that EMS at least 49% lower than levels predicted...
Michigan dairy farm residents ate products containing polybrominated biphenyls (PBB's) after the accidental contamination of animal feed with chemical in that state 1973. The circulating blood lymphocytes these show significant changes. Abnormalities include decreases numbers and percentages peripheral form rosettes either sheep erythrocytes alone or sensitized antibody complement, increases no detectable surface markers ("null" cells), altered responses to tests designed evaluate functional...
Previous studies have suggested that exposure to polychlorinated biphenyls (PCBs) may alter thyroid function, but data on effects of PCB other endogenous hormones has been lacking. The current study is ancillary a larger investigation the Great Lakes fish consumption PCBs and reproductive function. In we examine associations PCBs, 1,1-bis (4-chlorophenyl)-2,2-dichloroethene (DDE), with steroid in 178 men DDE, 51 women from original study. Serum level are associated significantly lower levels...
Thyroid hormone homeostasis can be disrupted by exposure to ubiquitous and bioaccumulative organochlorines such as polychlorinated biphenyls (PCBs) dibenzo-p-dioxins (PCDDs). Whereas investigations of health effects have generally focused on human populations with relatively high exposures through occupation, accident, or fish consumption, general population may also carry risk.We studied associations total thyroxine (T(4)) thyroid-stimulating (TSH) PCBs, dioxin-like toxic equivalents...
Exposure misclassification is a serious concern in environmental epidemiology, as errors the dependent variable (exposure) may dilute or magnify effect size. biomarkers overcome many sources of bias exposure assessment, but they have limitations that are often overlooked. One such
As most carriers of genes for recessive deafness do not display hearing impairment to a greater extent than average, it is impossible identify suspected gene by ordinary audiometry. In the study reported here more advanced test methods, namely Békésy audiometry and stapedius reflex test, have been applied in an attempt detect any subclinical peculiarities hearing; material consisted group 30 parental pairs with normal strong indication genetic deafness; they had 74 children, 47 them severe...
Disaster epidemiology (i.e., applied in disaster settings) presents a source of reliable and actionable information for decision-makers stakeholders the management cycle. However, epidemiological methods have yet to be routinely integrated into response fully communicated leaders. We present framework consisting rapid needs assessments, health surveillance, tracking registries, investigations, including risk factor outcome studies evaluation interventions, which can practiced throughout...
Stimulation with an air jet in the orbital region is shown to elicit a recordable reflex activity m. tensor tympani. This fact offers additional possibilities differential diagnosis of hearing impairments, e.g. otosclerosis. The studied regarded as component startle response.