A5082423826- Stress Responses and Cortisol
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurogenesis and neuroplasticity mechanisms
- Neuroscience and Neuropharmacology Research
- Memory and Neural Mechanisms
- Nerve injury and regeneration
- Tryptophan and brain disorders
- Neurotransmitter Receptor Influence on Behavior
- Intensive Care Unit Cognitive Disorders
- Treatment of Major Depression
- Adipose Tissue and Metabolism
- Neuropeptides and Animal Physiology
- Neural dynamics and brain function
- Anesthesia and Neurotoxicity Research
- Nuclear Receptors and Signaling
- Receptor Mechanisms and Signaling
- Advanced Neuroimaging Techniques and Applications
- Neurological Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Cancer-related cognitive impairment studies
- Phosphodiesterase function and regulation
- Apelin-related biomedical research
- Barrier Structure and Function Studies
- Peroxisome Proliferator-Activated Receptors
- Functional Brain Connectivity Studies
Trinity College Dublin
2011-2022
Schizophrenia is a neurodevelopmental disorder that affects up to 1% of the general population. Various genes show associations with schizophrenia and very weak nominal association tight junction protein, claudin-5, has previously been identified. Claudin-5 expressed in endothelial cells forming part blood-brain barrier (BBB). Furthermore, occurs 30% individuals 22q11 deletion syndrome (22q11DS), population who are haploinsufficient for claudin-5 gene. Here, we variant gene weakly associated...
Exposure to severe and prolonged stress has detrimental effects on the hippocampus. However, relatively little is known about gradual changes in hippocampal structure, its behavioral consequences, over course of repeated stress. Behavioral analyses during 10 days chronic pointed a delayed decline spatial memory, full impact which evident only after end In contrast, concurrent volumetric measurements same animals revealed significant reduction volumes stressed relative their unstressed...
Abstract Consolidation of long‐term memory is dependent on synthesis new proteins in the hippocampus and associated cortical regions. The neurotrophin brain‐derived neurotrophic factor (BDNF) tightly regulated by activity‐dependent cellular processes strongly linked with mechanisms underlying learning memory. BDNF activation tyrosine receptor kinase (TrkB) stimulates intracellular signaling cascades implicated plasticity, including extracellular‐signal related (ERK)/mitogen‐activated protein...
Abstract Post-operative cognitive dysfunction (POCD) is a debilitating clinical phenomenon in elderly patients. Management of pain complicated because analgesic opiates elicit major side effects. In contrast, paracetamol (acetaminophen) has shown efficacy, no impact on cognition, and its effects are well tolerated. We investigated the efficacy paracetamol, compared to opioid buprenorphine, model POCD by investigating decline, allodynia, peripheral hippocampal cytokines levels, microtubule...
Place cells are that exhibit location-dependent responses; they have mostly been studied in the hippocampus. also reported rat claustrum, an underexplored paracortical region with extensive corto-cortical connectivity. It has hypothesised claustral neuronal responses anchored to cortical visual inputs. We show place remap when inputs eliminated from environment, and this remapping is NMDA-receptor-dependent. Eliminating input decreases delta-band oscillatory activity, increases theta-band...
Abstract Rationale Many patients respond inadequately to antidepressant drug treatment; the search for alternate pharmacological treatment mechanisms is ongoing. Until 1950’s, opium was sometimes used treat depression, but eventually abandoned due addiction risk. Recent insights into opioid biology have sparked a renewed interest in potential properties of opioids. Objective We studied how mu (MOR), kappa (KOR) and delta (DOR) receptor ligands affect dysregulation motivated behavior...
Abstract Post-operative cognitive dysfunction (POCD) is a debilitating clinical phenomenon in elderly patients. Management of pain complicated because analgesic opiates elicit major side effects. In contrast, paracetamol (acetaminophen) has shown efficacy, no impact on cognition, and its effects are well tolerated. We investigated the efficacy paracetamol, compared to opioid buprenorphine, model POCD by investigating decline, allodynia, peripheral hippocampal cytokines levels, microtubule...
Abstract Place cells are exhibiting location-dependent responses; they have mostly been studied in the hippocampus. also reported rat claustrum, an underexplored paracortical region with extensive corto-cortical connectivity. It has hypothesised that claustral neuronal responses anchored to cortical visual inputs. We show place remap when inputs eliminated from environment and this remapping is NMDA-receptor-dependent. Eliminating input enhances delta-band oscillatory activity without...