A5066604596- Memory and Neural Mechanisms
- Neuroscience and Neuropharmacology Research
- Stress Responses and Cortisol
- Receptor Mechanisms and Signaling
- Neurotransmitter Receptor Influence on Behavior
- Neuroendocrine regulation and behavior
- Circadian rhythm and melatonin
- Cyclone Separators and Fluid Dynamics
- Nerve injury and regeneration
- Neuroinflammation and Neurodegeneration Mechanisms
- Mental Health Research Topics
- Apelin-related biomedical research
- Genetic Neurodegenerative Diseases
- Muscle and Compartmental Disorders
- Speech and Audio Processing
- Olfactory and Sensory Function Studies
- Neural dynamics and brain function
- Zebrafish Biomedical Research Applications
- Neurological disorders and treatments
- Alcohol Consumption and Health Effects
- Congenital heart defects research
- Spinal Hematomas and Complications
- Infant Health and Development
- Diet and metabolism studies
- Alcoholism and Thiamine Deficiency
University of Bristol
2022-2025
University of Cambridge
2017-2024
University Hospitals Birmingham NHS Foundation Trust
2022
University of Birmingham
2022
Queen Elizabeth Hospital Birmingham
2022
University of Edinburgh
2018
Sorbonne Université
2011-2017
Inserm
2014-2017
Institut de Biologie Paris-Seine
2014-2017
Centre National de la Recherche Scientifique
2014-2017
Convergent dopamine and glutamate signalling onto the extracellular signal-regulated kinase (ERK) pathway in medium spiny neurons (MSNs) of striatum controls psychostimulant-initiated adaptive processes underlying long-lasting behavioural changes. We hypothesised that physical proximity D1 (D1R) NMDA (NMDAR) receptors, achieved through formation D1R/NMDAR complexes, may act as a molecular bridge synergistic action on striatal plasticity responses to drugs abuse. found concomitant stimulation...
Rats display behaviours in response to aversive stimuli that communicate danger. Both male and female rats freezing ultrasonic vocalisation alarm calls, which are proposed have a communicative function. This study assessed dominance both using resource competition assay, recorded vocalisations produced by dominant pavlovian conditioning. To assess the ability of calls support subsequent learning conspecific, were played back submissive presence neutral odour. sexes responded playback calls....
Huntington's Disease (HD) is the most frequent neurodegenerative disease caused by an expansion of polyglutamines (CAG). The main clinical manifestations HD are chorea, cognitive impairment, and psychiatric disorders. transmission autosomal dominant with a complete penetrance. has single genetic cause, well-defined neuropathology, informative pre-manifest testing available. Striatal atrophy begins as early 15 years before onset continues throughout period manifest illness. Therefore,...
Extinction of a cued-fear memory within the reconsolidation window has been proposed to prevent fear reacquisition by interference. This 'retrieval-extinction' procedure received interest for its therapeutic potential reduce impact memories on behavior. To fully exploit potential, it is critical understand mechanisms that underlie effect. If effect depends upon original memory, then would be predicted destabilization, induced prediction error, observing Here, dependency retrieval-extinction...
Fear and anxiety are adaptive states that allow humans animals alike to respond appropriately threatening cues in their environment. Commonly used tasks for studying behaviour akin fear rodent models Pavlovian threat conditioning the elevated plus maze (EPM), respectively. In rodents learn associate an aversive event with a specific stimulus or context. The learnt association between two stimuli (the 'memory') can then be recalled by re-exposing subject conditioned stimulus. is argued...
Under certain conditions pavlovian memories undergo reconsolidation, whereby the reactivated memory can be disrupted by manipulations such as knockdown of zif268. For instrumental memories, reconsolidation disruption is less well established. Our previous, preliminary data identified that there was an increase in Zif268 posterior dorsolateral striatum (pDLS) after expression habit-like 'response' memory, but not goal-directed 'place' on a T-maze task. Here, requirement for response tested...
Abstract Background Peripheral nerve injuries (PNIs) can be acquired by patients in intensive care unit (ICU) who are critically unwell with Covid pneumonitis. Prone position ventilation has been linked to this life‐changing complication. Aim To reduce the occurrence and severity of PNIs for pneumonitis requiring prone positioning whilst sedated ventilated ICU. Study Design This study is a quality improvement project that evolved over course first two surges admissions within ICU at Queen...
Oxytocin is a peptide released into brain regions associated with the processing of aversive memory and threat responses. Given expression oxytocin receptors across this vigilance surveillance system brain, we investigated whether pharmacological antagonism receptor would impact contextual conditioning memory. Adult male rats were conditioned to form an The effects peripheral administration either competitive antagonist Atosiban or noncompetitive L-368,899 compared saline controls. treatment...
ABSTRACT Threat detection prompts reactions classified either as fear (obvious, predictable, immediate threat) or anxiety (ambiguous, sustained, distant threat). Hypervigilance is a state of sensitivity to threatening stimuli and an attentional bias symptomatic disorders. In rodents, threat can be measured by freezing behaviour production ultrasonic vocalisation (USV) alarm calls. The amygdala classically associated with fear-like responses, whereas the bed nucleus stria terminalis (BNST)...
Aims Overactive negative memories are thought to contribute the core symptoms of psychiatric conditions such as anxiety disorders or post-traumatic stress disorder (PTSD). For talking therapies, exposure therapy, there high rates relapse demonstrating necessity for innovative new treatments. It is that enhancing ability extinguish fear responses reactivation these in patients with pharmacological adjunct treatments will enhance efficacy interventions. N-methyl D-aspartate receptors (NMDARs)...
Fear and anxiety are adaptive states that allow humans animals alike to respond appropriately threatening cues in their environment. Commonly used tasks for studying behaviour akin fear rodent models pavlovian threat conditioning the elevated plus maze (EPM) respectively. In rodents learn associate an aversive event with a specific stimulus or context. The learnt association between two stimuli (the memory) can then be recalled by re-exposing subject conditioned stimulus. is argued measure...
Oxytocin is a peptide released into brain regions associated with the processing of aversive memory and threat responses. Given expression oxytocin receptors across this vigilance surveillance system brain, we investigated whether pharmacological antagonism receptor would impact contextual conditioning memory. Adult male rats were conditioned to form an The effects peripheral administration either competitive antagonist Atosiban or noncompetitive L-368,899 compared saline controls. treatment...