A5072984121- Pulmonary Hypertension Research and Treatments
- High Altitude and Hypoxia
- Cardiovascular Effects of Exercise
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Heart Failure Treatment and Management
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Cancer, Hypoxia, and Metabolism
- Hormonal Regulation and Hypertension
- Cardiac Fibrosis and Remodeling
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Travel-related health issues
- Cardiovascular Function and Risk Factors
- Mast cells and histamine
- Bone and Dental Protein Studies
- MicroRNA in disease regulation
- Congenital Heart Disease Studies
- Renin-Angiotensin System Studies
- Protease and Inhibitor Mechanisms
- Food Allergy and Anaphylaxis Research
- RNA modifications and cancer
- Neuroscience of respiration and sleep
- Enzyme function and inhibition
- Congenital heart defects research
- ATP Synthase and ATPases Research
- Infectious Aortic and Vascular Conditions
Cardio-Pulmonary Institute
2019-2024
Justus-Liebig-Universität Gießen
2016-2024
German Center for Lung Research
2018-2024
University of Freiburg
2021-2024
Universities of Giessen and Marburg Lung Center
2016-2023
Max Planck Institute for Heart and Lung Research
2020
National Center of Cardiology and Internal Medicine
2016-2017
Endothelial cells play crucial roles in physiology and are increasingly recognized as therapeutic targets cardiovascular disease. Here, we analyzed the regulatory landscape of cardiac endothelial by assessing chromatin accessibility, histone modifications, 3D organization confirmed functional relevance enhancer-promoter interactions CRISPRi-mediated enhancer silencing. We used this dataset to explore mechanisms transcriptional regulation disease compared six different experimental models...
Abstract Right ventricular ( RV ) remodeling represents a complex set of functional and structural adaptations in response to chronic pressure or volume overload due various inborn defects acquired diseases is an important determinant patient outcome. However, the underlying molecular mechanisms remain elusive. We investigated time course changes murine model overload‐induced hypertrophy C57Bl/6J mice. Using magnetic resonance imaging, we assessed structure function at different points for...
In response to various stressors, cardiac chambers undergo structural remodeling. Long-term exposure of the right ventricle (RV) pressure or volume overload leads its maladaptive remodeling, associated with RV failure and increased mortality. While left ventricular adverse remodeling is well understood therapeutic options are available emerging, remains underexplored, no specific therapies currently available. Accumulating evidence implicates role mast cells in Mast produce release numerous...
Background: Circulating apoptotic signals (CASs) have been described in the pathologies associated with dysregulated apoptosis, such as cancer, heart diseases, and pulmonary hypertension (PH). However, nothing is known about expression profiles of these markers circulation humans exposed to acute chronic effects high altitude (HA). Methods: Gene levels different (ASs) were analyzed human artery smooth muscle cells (PASMCs) upon hypoxia incubation. In addition, we measured plasma values...
Pulmonary arterial hypertension is a severe respiratory disease characterized by pulmonary artery remodeling. RV dysfunction and dysregulated circulating metabolomics are associated with adverse outcomes in hypertension. We investigated effects of tadalafil macitentan alone or combination on the plasma SuHx PAB models. For model, rats were injected SU5416 exposed to hypoxia for three weeks then returned normoxia treated either (10 mg/kg chow) their (both 10 two weeks. subjected sham surgery...
Although the response of right ventricle (RV) to increased afterload is an important determinant patient outcome, very little known about underlying mechanisms. Mast cells have been implicated in pathogenesis left ventricular maladaptive remodeling and failure. However, role mast RV remains unexplored. We subjected cell-deficient WBB6F1-KitW/W-v (KitW/KitW-v) mice their cell-sufficient littermate controls (MC+/+) pulmonary artery banding (PAB). PAB led dilatation, extensive myocardial...
Background/Aims: Long-term high altitude residence leads to a sustained increase in pulmonary vascular resistance and elevation of artery pressure due chronic alveolar hypoxia. However, living at is also associated with other environmental factors such as cold. There still little experimental evidence suggesting detrimental effects low temperatures on the vasculature. Therefore, our objective was investigate acute cold exposure circulation Kyrgyz natives. Methods: Responses during controlled...
The leading cause of death in Pulmonary Arterial Hypertension (PAH) is right ventricular (RV) failure. tumor suppressor p53 has been associated with left hypertrophy (LVH) and remodeling but its role RV (RVH) unclear. purpose this study was to determine whether pharmacological activation by Quinacrine affects function the pulmonary artery banding (PAB) model compensated RVH mice. effects on cellular functions were studied isolated cardiomyocytes, cardiac fibroblasts endothelial cells (ECs)....