A5051772562- Long-Term Effects of COVID-19
- COVID-19 Clinical Research Studies
- COVID-19 and healthcare impacts
- Streptococcal Infections and Treatments
- High Altitude and Hypoxia
- Pulmonary Hypertension Research and Treatments
- Healthcare Systems and Public Health
- Rheumatoid Arthritis Research and Therapies
- Toxin Mechanisms and Immunotoxins
- Human Health and Disease
- Musculoskeletal Disorders and Rehabilitation
- Cardiovascular Disease and Adiposity
- Respiratory and Cough-Related Research
- Autoimmune and Inflammatory Disorders Research
- Liver Disease Diagnosis and Treatment
- Zoonotic diseases and public health
- Systemic Lupus Erythematosus Research
- Inflammasome and immune disorders
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Monoclonal and Polyclonal Antibodies Research
- Medical and Biological Ozone Research
- COVID-19 and Mental Health
- Otolaryngology and Infectious Diseases
- Mitochondrial Function and Pathology
- Pain Management and Treatment
National Center of Cardiology and Internal Medicine
2009-2023
Center for Rheumatology
2018
Brigham and Women's Hospital
2012
Harvard University
2012
St. Marianna University School of Medicine
2009-2010
The epidemiological situation involving rheumatic fever (RF) and heart disease (RHD) not only remains unresolved but is also a cause of serious concern due to the rapid increase in incidence RF/RHD many developing countries. After collapse Soviet Union, republics Central Asia experienced an economic decline that directly affected public health sector this region. This main high prevalence infectious diseases Asia, including streptococcal tonsillopharyngitis, which carries risk complications...
Background: Circulating apoptotic signals (CASs) have been described in the pathologies associated with dysregulated apoptosis, such as cancer, heart diseases, and pulmonary hypertension (PH). However, nothing is known about expression profiles of these markers circulation humans exposed to acute chronic effects high altitude (HA). Methods: Gene levels different (ASs) were analyzed human artery smooth muscle cells (PASMCs) upon hypoxia incubation. In addition, we measured plasma values...
Background/Aims: Long-term high altitude residence leads to a sustained increase in pulmonary vascular resistance and elevation of artery pressure due chronic alveolar hypoxia. However, living at is also associated with other environmental factors such as cold. There still little experimental evidence suggesting detrimental effects low temperatures on the vasculature. Therefore, our objective was investigate acute cold exposure circulation Kyrgyz natives. Methods: Responses during controlled...
Rheumatologic and public health services of Central Asia's republics have suffered hugely as a result social economic declines following the dissolution Union Soviet Socialist Republics (USSR) transition these to market economies. Between 1990 2000 there was mass outflow highly skilled rheumatologists teachers researchers in rheumatology countries abroad, leading significant deprivation rheumatological service Asian countries. During this time, continued growth various rheumatic diseases...
Rheumatic fever (RF) is well known disease as a result of frequent complication the group A b-hemolytic streptococcal (GABHS) tonsillopharyngitis, have noticeably grown for last 15 years among young generation in Kyrgyz Republic. It important to hold study about prevalence RF and GABHS their susceptibility antibiotics Republic.We studied 200 children with chronic tonsillopharyngitis at National Center Pediatrics Child Surgery Bishkek (the Republic) from August till September 2008. 188 (48...
Rheumatology has pioneered in the study of autoantibodies by showing that they are not only involved pathogenesis but also highly useful as diagnostic biomarkers.The biomarker aspect autoimmunity gained increasing importance cancer and many insights have contributed to understanding significance cancer.Features rheumatic disorders: In diseases no individual autoantibody-antigen system sufficient combination sensitivity specificity serve a biomarker.Instead, several antigen-antibody systems...
The role of microparticles (MPs) and cold in high altitude pulmonary hypertension (HAPH) remains unexplored. We investigated the impact long-term exposure on circulation lowlanders high-altitude natives MPs. Pulmonary hemodynamics were evaluated using Doppler echocardiography at end colder warmer seasons. further examined miRNA content MPs isolated from study participants studied their effects human artery smooth muscle (hPASMCs) endothelial cells (hPAECs). Long-term to environment was...
<h3>Background</h3> Rheumatoid arthritis (RA) is a chronic inflammatory disease affecting the synovial joints, often with progressive and destructive course, associated production of wide range autoantibodies, their detection has diagnostic prognostic implication. <h3>Objectives</h3> This study was to estimate value antibodies against cyclic citrullinated peptide (ACCP) nuclear antigen RA33 IgA rheumatoid factor (RF) versus routinely used profile autoantibodies in work-up RA....
Background: In patients with SLE previous adverse obstetric outcome the risk of an in subsequent pregnancy rises.In this prospective cohort such primary objective was to assess impact a protocol based care.Methods: Between March and September 2010 all fulfilling ACR classification criteria at least one (maternal; preterm labour, pre ecalampsia or medical termination (MTP) view flare, foetal; miscarriage, IUGR, birth, low birth weight (LBW), intrauterine death still birth) desirous having...