A5004126768- Neonatal and fetal brain pathology
- Neonatal Respiratory Health Research
- Pregnancy and preeclampsia studies
- Birth, Development, and Health
- Neuroscience of respiration and sleep
- Retinopathy of Prematurity Studies
- Retinal Development and Disorders
- Anesthesia and Neurotoxicity Research
- Cardiovascular Conditions and Treatments
- Infant Development and Preterm Care
- Preterm Birth and Chorioamnionitis
- Infant Health and Development
- Congenital heart defects research
- Noise Effects and Management
- Neurological Disorders and Treatments
- Neurogenesis and neuroplasticity mechanisms
- Delphi Technique in Research
- Nerve injury and regeneration
- Hearing Loss and Rehabilitation
- Hearing, Cochlea, Tinnitus, Genetics
- Advanced Glycation End Products research
- Congenital Diaphragmatic Hernia Studies
- Traumatic Brain Injury and Neurovascular Disturbances
- Glaucoma and retinal disorders
- Assisted Reproductive Technology and Twin Pregnancy
La Trobe University
2017
The University of Melbourne
2002-2011
Monash University
2004-2010
In-Q-Tel
2006
National Health and Medical Research Council
2006
Intrauterine infection and inflammation have been linked to preterm birth brain damage. We hypothesized that recombinant human erythropoietin (rhEPO) would ameliorate damage in anovine model of fetal inflammation. At 107 ± 1 day gestational age (DGA), chronically catheterized sheep received on 3 consecutive days 1) an intravenous bolus dose lipopolysaccharide ([LPS] ∼0.9 μg/kg; n = 8); 2) LPS, followed at hour by 5,000 IU/kg rhEPO (LPS + rhEPO, or 3) (n 5). Untreated fetuses 8) served as...
We tested the hypotheses that an episode of hypoxemia near mid-gestation in fetal sheep has long-term effects on brain development and extent type damage is related to stage within a particular structure at time hypoxemia. Fetal (n = 8) were made hypoxemic 90 ± 2 days (term ∽147 days) by restricting maternal blood supply placenta for 12 hours (h) using vascular clamp so as reduce arterial O2 saturation 50%–60%. Fetuses killed 35 later brains analysed histologically immunohistochemically....
BACKGROUND. The survival of prematurely born infants has greatly increased in recent decades because advances neonatal intensive care, which have included the advent ventilatory therapies. However, there is limited knowledge as to impact these therapies on developing brain. purpose this work was evaluate influence randomized respiratory therapy with either early continuous positive airway pressure or delayed preceded by ventilation extent brain injury and altered development a delivered...
Chronic placental insufficiency (CPI) has the potential to affect fetal brain development and cause injury. Our aim was determine effects of exposure CPI during late gestation on retinal structure neurotrophin expression 8 weeks after birth. Six sheep were exposed CPI, induced by umbilico-placental embolization, from 120 days until term (∼147 days) such that arterial oxygen saturation (SaO2) reduced ∼50%. Nine untreated animals served as controls. During PO2, SaO2, pH, growth (p < 0.05);...
Purpose.: Intrauterine infection is a common antecedent of preterm birth. Infants born very are at increased risk for neurologic dysfunction, including visual deficits. With increasing survival infants, there need therapies that prevent adverse outcomes. Using an ovine model, the authors investigated neuroprotective potential recombinant human erythropoietin (rhEPO) on retinal injury induced by intrauterine inflammation. Methods.: At 107 ± 1 days gestational age (DGA), chronically...
Premature infants now have an improved chance of survival, but the impact respiratory therapies on brain, particularly cerebellum, remains unclear. We examined effects early nasal continuous positive airway pressure (EnCPAP) ventilation and delayed (Dn) CPAP development cerebellum in prematurely delivered baboons. The baboons were at 125 +/- 2days gestation ventilated for 28 days with either EnCPAP commencing 24 hours (n = 5) or DnCPAP 5 5). Gestational controls 4) 153 days. Cerebella...
purpose. Chronic placental insufficiency (CPI) severe enough to cause growth restriction (GR) results in alterations the retina, including a reduction tyrosine hydroxylase immunoreactive (TH-IR)-dopaminergic amacrine cells. Brain-derived neurotrophic factor (BDNF) plays role development of retinal dopaminergic network and may therefore be an appropriate therapy for restoring cells after prenatal compromise. This study was conducted (1) establish whether BDNF its receptor NTRK2 (Trk B) are...
Reduced birth weight is associated with an increased risk of visual impairments. This study was undertaken to determine whether prenatal exposure a chronic compromise sufficient cause fetal growth restriction (FGR) results in long-term alterations the retina and optic nerve.FGR induced by umbilicoplacental embolization (UPE) two cohorts pregnant ewes from (1) 120 days gestation (dg) until 140 dg (2) term ( approximately 147 dg). Control fetuses were not subjected UPE. The structure...
Very low birth weight (VLBW) and fetal growth restriction are associated with increased risks of long-term visual impairments, including alterations to contrast sensitivity, a parameter mediated in part by dopaminergic amacrine cells. This study was conducted determine whether chronic placental insufficiency (CPI), sufficient cause restriction, results neurochemical retinal interneurons, specifically horizontal cell populations near term.CPI induced just before midgestation (term...
Intrauterine infection has been linked to preterm delivery and neurologic injury. The purpose of this study was investigate the effects fetal inflammation induced by exposure endotoxin on structure neurochemistry retina optic nerve.The bacterial endotoxin, lipopolysaccharide (LPS), administered sheep at approximately 0.65 147-day gestation period via repeated bolus doses (1 microg/kg per day) over 5 days, with retinas nerves assessed 10 days after first LPS exposure.In retina, total number...
Prenatal hypoxia affects neuronal survival and process outgrowth. Brain-derived neurotrophic factor, which influences neural growth, is decreased in these conditions. We tested whether addition of brain-derived factor enhances growth neurons cultured from guinea pig fetuses (n=7) compromised by chronic placental insufficiency 30-52 days gestation (term approximately 67 days). Cultures were prepared the olfactory bulb, hippocampus cerebellum. Compared with controls (n=7), resulted reduced...