A5100349843- Cancer Genomics and Diagnostics
- Advanced Combustion Engine Technologies
- Mitochondrial Function and Pathology
- Heat transfer and supercritical fluids
- Combustion and flame dynamics
- Genetic factors in colorectal cancer
- Single-cell and spatial transcriptomics
- Advanced Radiotherapy Techniques
- Radiative Heat Transfer Studies
- Laser-induced spectroscopy and plasma
- Metabolism and Genetic Disorders
- Laser Material Processing Techniques
- Radiation Therapy and Dosimetry
- Breast Cancer Treatment Studies
- ATP Synthase and ATPases Research
- Peroxisome Proliferator-Activated Receptors
- Lipid metabolism and biosynthesis
- Gene expression and cancer classification
- Thermodynamic and Exergetic Analyses of Power and Cooling Systems
- Atomic and Molecular Physics
- Ocular and Laser Science Research
- Theoretical and Computational Physics
- Petroleum Processing and Analysis
- Solid State Laser Technologies
- Heat Transfer Mechanisms
Shanghai Ninth People's Hospital
2024
Shanghai Jiao Tong University
2024
University of Science and Technology of China
2011-2024
Shanghai Institute of Optics and Fine Mechanics
2022
Beijing Institute of Technology
2014
Electric Power Research Institute
2014
National Synchrotron Radiation Laboratory
2011
Academia Sinica
2006
Abstract Extrachromosomal circular DNA (eccDNA) is currently attracting considerable attention from researchers due to its significant impact on tumor biogenesis. High-throughput sequencing (HTS) methods for eccDNA identification are continually evolving. However, an efficient pipeline the integrative and comprehensive analysis of obtained HTS data still lacking. Here, we introduce eccDNA-pipe, accessible software package that offers a user-friendly conducting starting raw data. This dataset...
Mitochondria are in a constant balance of fusion and fission. Excessive fission or deficient leads to mitochondrial fragmentation, causing dysfunction physiological disorders. How the cell prevents excessive mitochondria is not well understood. Here, we report that yeast AAA-ATPase Yta4, which homolog budding Msp1 responsible for clearing mistargeted tail-anchored (TA) proteins on mitochondria, plays critical role preventing The absence Yta4 mild fragmentation Dnm1-dependent manner but...
Abstract Advanced stellarators are typically optimized in two stages. The plasma equilibrium is first, followed by the design of coils/permanent magnets. However, magnets second stage may become too complex to achieve desired equilibrium. To address this problem, a quasi-single-stage optimization method has been proposed. In paper, we introduce for designing permanent magnet (PM) stellarators. new approach combines straightforward PM metrics penalize maximum required thickness and mismatch...
Extrachromosomal circular DNA (eccDNA) is crucial in oncogene amplification, gene transcription regulation, and intratumor heterogeneity. While various analysis pipelines experimental methods have been developed for eccDNA identification, their detection efficiencies not systematically assessed. To address this, we evaluate the performance of 7 using seven simulated datasets, terms accuracy, identity, duplication rate, computational resource consumption. We also compare efficiency through...
Regioregular poly(3-hexylthiophene) (P3HT) was synthesized by a Grignard metathesis method. The annealed and fast cooled P3HT films were studied UV-vis absorption spectroscopy, atomic force microscopy, grazing incidence X-ray diffraction (GIXRD) measurements. It is demonstrated that thermal annealing at around the onset temperature of melting point polymer results in film having highest interchain intrachain orders while preserving original morphological features. However, has or lowest...
Mitochondria are involved in many cellular activities, including energy metabolism and biosynthesis of nucleotides, fatty acids amino acids. Mitochondrial morphology is a key factor dictating mitochondrial functions. Here, we report that the acyl-CoA-binding protein (ACBP) Acb1 fission yeast Schizosaccharomyces pombe required for maintenance tubular proper respiration. The absence causes severe fragmentation dynamin-related Dnm1-dependent manner impairs Moreover, regulates remodelling lipid...
Abstract In this paper, the Chinese Fusion Engineering Testing Reactor (CFETR) power conversion system, with a supercritical CO 2 (SCO ) Brayton cycle, is designed, analyzed and optimized. Considering pulse operation of reactor, heat storage loop high temperature molten salt low concrete introduced. Based on parameters first cooling loop, CFETR designed studied. A new SCO cycle for dual sources, blanket divertor, developed optimized using genetic algorithm. Compared to other simple...
For high performance imaging and focusing applications, figure errors can degrade the of lenses, especially in catoptric catadioptric lenses. An automatic balancing method is proposed. By using geometrical optics, linear relationships between wavefront error (WFE) lens for three kinds optical surfaces are established verified. The WFE sensitivity to based on this relationship analyzed before clocking optimization improve efficiency optimization. procedure indirectly optimizes rotation angle...
Abstract The reversed field pinch (RFP) is a toroidal magnetic configuration in which plasmas can spontaneously transform into different self-organized states. Among various states, the ‘quasi-single-helical’ (QSH) state has dominant component for and significantly improves confinement. Many theoretical experimental efforts have investigated transitions among This paper employs multi-region relaxed magnetohydrodynamic model to study properties of QSH other stepped-pressure equilibrium code...
Abstract In the reversed field pinch (RFP), plasmas exhibit various self-organized states. Among these, three-dimensional (3D) helical state known as “quasi-single-helical” (QSH) enhances RFP confinement. However, accurately describing equilibrium is challenging due to presence of 3D structures, magnetic islands, and chaotic regions. It diffcult obtain a balance between available diagnostic real structure. To address this issue, we introduce KTX3DFit, new reconstruction code specifically...
Adipocytes play a crucial role in tissue regeneration, contributing to the restoration of damaged areas and modulating inflammatory milieu. The modulation gene expression through chemically modified PPARγ mRNA (PPARγ-modRNA) introduces sophisticated approach precisely control adipogenic processes. This study aims explore potential PPARγ-modRNA 3T3-L1 preadipocytes its wound healing.
In order to solve the problem of high temperature corrosion water wall opposed fired ultra supercritical boiler, comprehensive study is carried out by combining theoretical analysis and experimental research, obtaining variation flue gas composition before after introduction near wind effect primary air velocity, central opening, swirl intensity outer secondary inner opening on in region. The results show that 1) significantly improves reducing atmosphere region; 2) among four parameters...
Abstract Extrachromosomal circular DNA (eccDNA) is crucial in oncogene amplification, gene transcription regulation, and intratumor heterogeneity. While various analysis pipelines experimental methods have been developed for eccDNA identification, their detection efficiencies not systematically assessed. To address this, we evaluated the performance of 7 using three simulated datasets, terms accuracy, similarity, duplication rate, computational resource consumption. We also compared...
The exergy losses in the adiabatic premixed oxy-fuel combustion are quantitatively analysed. global loss decreases with increasing equivalence ratio. of chemical reaction is comparable to that internal thermal energy exchange for low ratio while mixing process negligible. To keep similar thermodynamic characteristics conventional combustion, O2/CO2 mole should be 30/70 combustion. on at same conditions following order: CH4 > H2 CO. preheating inlet oxidant improves efficiency
A constant heat flux transfer test bed is built, and experimental study on external characteristics of a new type elastic tube bundle conducted, obtaining overall local performance the at different Re numbers. The results show that, for fluid entirely impacting free end better than that completely entering from exchanger inlet. Besides, greatest occurs condition impinging small bundle. Similar occur when impinges big / respectively, namely lower coefficient fixed end, highest reason which...
Combustion instability in jet engines impedes efficient burning of fuel and degrades engine performance. Moreover, it can cause damage to the combustion chamber even lead a destructive failure operation engine. Considerable work has been carried out both theoretically experimentally understand characteristics this develop control methods. These studies have found based upon different on-line tests. However, they incurred high costs often achieved limited results. This paper presents an...
To shave peaks and fill valleys, the thermal power units are required to increase their operating time in low-load range which negatively affects denitrification of selective catalytic reduction (SCR). quantify effect, it is necessary make an accurate prediction on inlet gas temperature (SCRIGT). First, extreme gradient boosting (XGBoost) model adopted using unit parameters as inputs load∙SCRIGT -1 output. The result shows maximum absolute errors 23.78% 20.79% from two with different type...
Femtosecond laser ablation has been demonstrated to be a versatile tool produce micro/nanoscale features with high precision and accuracy. However, the use of fluence increase efficiency usually results in unwanted effects, such as redeposition debris, formation recast layer heat-affected zone or around craters. Here we circumvent this limitation by exploiting thin frost thickness tens microns, which can directly formed condensation water vapor from air onto exposed surface whose temperature...
Abstract Background This study aimed to compare the advantages and disadvantages of intensity-modulated radiation therapy (IMRT) volumetric-modulated arc (VMAT), in left-sided breast cancer patients who underwent hypofractionated radiotherapy after a modified radical mastectomy. Methods For study, 20 with required adjuvant mastectomy were selected randomly. The specified dose 43.5Gy/15f was adopted plan for IMRT VMAT. Dose volume histograms (DVH) employed evaluate distribution planning...