A5073096861- Ubiquitin and proteasome pathways
- Microtubule and mitosis dynamics
- Genetics and Neurodevelopmental Disorders
- Phytochemicals and Antioxidant Activities
- Cancer-related Molecular Pathways
- CRISPR and Genetic Engineering
- Plant Genetic and Mutation Studies
- Natural Antidiabetic Agents Studies
- Advanced biosensing and bioanalysis techniques
- Autophagy in Disease and Therapy
- Peptidase Inhibition and Analysis
- Genomics and Rare Diseases
- ATP Synthase and ATPases Research
- Fungal Biology and Applications
- Mitochondrial Function and Pathology
- Cellular transport and secretion
- RNA and protein synthesis mechanisms
- Phytochemistry and Bioactivity Studies
- Amino Acid Enzymes and Metabolism
Okinawa Institute of Science and Technology Graduate University
2024
Hamamatsu University School of Medicine
2018-2022
University of Rajshahi
2019
Mitotic duration is tightly constrained, and extended mitosis characteristic of problematic cells prone to chromosome missegregation genomic instability. We show here that mitotic extension leads the formation p53-binding protein 1 (53BP1)-ubiquitin-specific protease 28 (USP28)-p53 complexes are transmitted to, stably retained by, daughter cells. Complexes assembled through a Polo-like kinase 1-dependent mechanism during elicited p53 response in G
Objective The cytoplasmic fragile X mental retardation 1 interacting proteins 2 (CYFIP2) is a component of the WASP‐family verprolin‐homologous protein (WAVE) regulatory complex, which involved in actin dynamics. An obvious association CYFIP2 variants with human neurological disorders has never been reported. Here, we identified de novo hotspot neurodevelopmental and explore possible involvement mutants WAVE signaling pathway. Methods We performed trio‐based whole‐exome sequencing (WES) 210...
Abstract Vacuolar H + -ATPases (V-ATPases) transport protons across cellular membranes to acidify various organelles. ATP6V0A1 encodes the a1-subunit of V0 domain V-ATPases, which is strongly expressed in neurons. However, its role brain development unknown. Here we report four individuals with developmental and epileptic encephalopathy variants: two a de novo missense variant (R741Q) other biallelic variants comprising one almost complete loss-of-function (A512P N534D). Lysosomal...
By whole exome sequencing, we identified three de novo RHOBTB2 variants in patients with epileptic encephalopathies (EEs). Interestingly, all showed acute encephalopathy (febrile status epilepticus), magnetic resonance imaging revealing hemisphere swelling or reduced diffusion various brain regions. encodes Rho-related BTB domain-containing protein 2, an atypical Rho GTPase that is a substrate-specific adaptor itself substrate for the Cullin-3 (CUL3)-based ubiquitin ligase complex. Transient...
Background: Adverse side effects of currently available therapies against cancer, leads scientists to find effective compounds from natural sources. Objective: In the present study, stem-bark Mycelia champaca is subjected evaluate its antiproliferative effect Ehrlich Ascites Carcinoma (EAC) cells. To date, anti-proliferative M. bark extract EAC cell line has not been reported elsewhere. Therefore, we intended investigate potential cells in vivo. Methods: vivo anticancer activity was...