A5046711375- Nanoparticle-Based Drug Delivery
- Drug Transport and Resistance Mechanisms
- Ginseng Biological Effects and Applications
- Gold and Silver Nanoparticles Synthesis and Applications
- Photoreceptor and optogenetics research
- Advanced Drug Delivery Systems
- Pharmacological Effects of Natural Compounds
- Neonatal and fetal brain pathology
- Neural dynamics and brain function
- Healthcare and Venom Research
- Mitochondrial Function and Pathology
- Neuroscience and Neural Engineering
- Ginger and Zingiberaceae research
- Pharmacogenetics and Drug Metabolism
- Traditional Chinese Medicine Analysis
- Nicotinic Acetylcholine Receptors Study
- Plant-based Medicinal Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Barrier Structure and Function Studies
- Piperaceae Chemical and Biological Studies
- Neuroscience and Neuropharmacology Research
- Phenothiazines and Benzothiazines Synthesis and Activities
Ningxia Medical University
2023
Otto-von-Guericke University Magdeburg
2017-2020
Center for Behavioral Brain Sciences
2017
Central South University
2015
Academy of Military Medical Sciences
2015
Beijing Radiation Center
2015
Repetitive transorbital alternating current stimulation (rtACS) improves vision in patients with chronic visual impairments and an acute treatment increased survival of retinal neurons after optic nerve crush (ONC) rodent models system injury. However, despite this protection no functional recovery could be detected rats, which was interpreted as evidence "silent survivor" cells. We now analysed the mechanisms underlying survival" effect. Using vivo microscopy retina we investigated...
Because the blood-brain barrier (BBB) is an obstacle for drug-delivery, carrier systems such as polybutylcyanoacrylate (PBCA) nanoparticles (NPs) have been studied. Yet, little known of how physiochemical features size, surfactants and surface charge influence BBB passage in vivo. We now used a rat model vivo imaging retina - which brain tissue can reflect situation at to study size determine NPs' ability cross blood-retina (BRB). Interestingly, poloxamer 188-modified,...
Enhancing cortical plasticity and brain connectivity may improve residual vision following a visual impairment. Since acetylcholine plays an important role in attention neuronal plasticity, we explored whether potentiation of the cholinergic transmission has effect on function restoration. To this end, evaluated for 4 weeks acetylcholinesterase inhibitor donepezil brightness discrimination, visually evoked potentials, cortex reactivity after bilateral partial optic nerve crush adult rats....
Minor changes in the composition of poloxamer 188-modified, DEAE-dextran-stabilized (PDD) polybutylcyanoacrylate (PBCA) nanoparticles (NPs), by altering physicochemical parameters (such as size or surface charge), can substantially influence their delivery kinetics across blood–retina barrier (BRB) vivo. We now investigated mechanisms underlying these different behaviors NP variations at biological barriers and on cellular body distribution. Retinal whole mounts from rats injected vivo with...
To study the effect of Siwu decoction on function and expression P-glycoprotein (P-gp) in Caco-2 cells. The Real-time quantitative poly-merase chain reaction (Q-PCR) was used to analyze mRNA MDR1 gene Flow cytometer uptake Rhodamine 123 cells, order evaluate efflux P-gp. Western blotting method detect P-gp protein Compared with blank control group, after incubation at concentrations 3.3, 5.0, 10.0 g x L(-1) for 24, 48, 72 h, up-regulated, suggesting inducing MDR1. After administration cells...