A5009925518- Vitamin D Research Studies
- Circadian rhythm and melatonin
- Burn Injury Management and Outcomes
- Hormonal Regulation and Hypertension
- Estrogen and related hormone effects
- Tryptophan and brain disorders
- Stress Responses and Cortisol
- Wound Healing and Treatments
- Photoreceptor and optogenetics research
- Polysaccharides Composition and Applications
- Skin Protection and Aging
- Allergic Rhinitis and Sensitization
- Dialysis and Renal Disease Management
- Antiplatelet Therapy and Cardiovascular Diseases
- Nanocomposite Films for Food Packaging
- Neurobiology and Insect Physiology Research
- Eicosanoids and Hypertension Pharmacology
- Fatty Acid Research and Health
- Genetic and Kidney Cyst Diseases
- Click Chemistry and Applications
- Vitamin C and Antioxidants Research
- Cholesterol and Lipid Metabolism
- Chronic Kidney Disease and Diabetes
- COVID-19 Clinical Research Studies
University of Alabama at Birmingham
2020-2023
Nicolaus Copernicus University
2021
Jagiellonian University
2012-2018
Instituto de Diagnóstico e Investigaciones Metabólicas
2009
University of Buenos Aires
2009
Abstract The interactions of derivatives lumisterol (L3) and vitamin D3 (D3) with liver X receptors (LXRs) were investigated. Molecular docking using crystal structures the ligand binding domains (LBDs) LXRα β revealed high scores for L3 hydroxymetabolites, similar to those natural ligands, predicting good receptor. RNA sequencing murine dermal fibroblasts stimulated D3-hydroxyderivatives LXR as second nuclear receptor pathway several D3-hydroxyderivatives, including 1,25(OH) 2 D3. This was...
Abstract The negative outcomes of COVID‐19 diseases respiratory distress (ARDS) and the damage to other organs are secondary a “cytokine storm” attendant oxidative stress. Active hydroxyl forms vitamin D anti‐inflammatory, induce antioxidative responses, stimulate innate immunity against infectious agents. These properties shared by calcitriol CYP11A1‐generated non‐calcemic hydroxyderivatives. They inhibit production pro‐inflammatory cytokines, downregulate NF‐κΒ, show inverse agonism on...
Abstract In the fly's visual system, morphology of cells and number synapses change during day. present study we show that in first optic neuropil (lamina) Drosophila melanogaster, a presynaptic active zone protein Bruchpilot (BRP) exhibits circadian rhythm abundance. day/night (or light/dark, LD) conditions level BRP increases two times, morning evening. The same pattern changes was detected whole brain homogenates, thus indicating majority peaks twice However, these abundance, measured as...
Abstract Melanoma is a leading cause of cancer deaths worldwide. Although immunotherapy has revolutionized the treatment for some patients, resistance towards therapy and unwanted side effects remain problem numerous individuals. Broad anti‐cancer activities melatonin are recognized; however, additional investigations still need to be elucidated. Herein, using various human melanoma cell models, we explore in vitro new insights into regulation by its metabolites which possess, on other side,...
Background. Autosomal dominant polycystic kidney disease (ADPKD) shows an increase in both urine monocyte chemoattractant protein-1 (MCP-1) and carotid intima–media thickness (CIMT) before changes serum creatinine concentration. Although microalbuminuria is index of progression, data on whether renal alterations vascular remodelling are already present at normal or minimally increased levels albumin excretion early stages the lacking. Methods. Forty-eight ADPKD patients (24.8 ± 0.8 years)...
We investigated the effects of melatonin and its selected metabolites, i.e., N1-Acetyl-N2-formyl-5-methoxykynurenamine (AFMK) 6-hydroxymelatonin (6(OH)Mel), on cultured human epidermal keratinocytes (HEKs) to assess their homeostatic activities with potential therapeutic implications. RNAseq analysis revealed a significant number genes distinct overlapping patterns, resulting in common regulation top diseases disorders. Gene Set Enrichment Analysis (GSEA), Reactome FIViZ, Ingenuity Pathway...
Pullulan and chitosan are biocompatible polysaccharides obtained from natural sources with many biomedical applications. Cationically modified polymers, such as pullulan after covalent attachment of glycidyltrimethylammonium chloride (GTMAC), showed beneficial biological properties. In the present study, it was clearly demonstrated confirmed that both cationically (chitosan-GTMAC pullulan-GTMAC) have antiatherosclerotic potential by inhibition atherosclerotic plaque development controlling...
Abstract Disclosure: A. Slominski: None. T. Kim: E. Podgorska: Z. Janjetovic: J. Stefan: S. Ravichandran: R.M. Y. Song: Szpotan: Mobley: C. Raman: Tang: A.M. Jetten: M.F. Holick: R. Tuckey: While the role of vitamin D3 in body homeostasis is well established, functions its photoderivative, lumisterol (L3), are gradually being appreciated. Previously, we reported that L3 can be metabolized by CYP11A1 and CYP27A1 to mono- dihydroxy-L3. Furthermore, have shown 7DHC reductase (DHCR7) does not...
Vitamin D3 acts through its most active form, calcitriol, 1α,25-dihydroxyvitamin [1,25(OH)2D3] as agonist of one the receptors involved in this ligand action, vitamin D receptor (VDR), which is also a transcription factor. Numerous modifications calcitriol at side-chain, C-ring, A-ring, triene system, alone or combination, well nonsteroidal mimics provided new VDR agonists and some antagonists with biological activity possible therapeutical potential. Some metabolites, including 20,23(OH)2D3...
Abstract New pathways of vitamin D3 (D3) activation initiated by CYP11A1 and involving other CYPs have been discovered. At least 15 hydroxyderivatives, including 20(OH)D3 as the major product, are generated these (1,2) with some being present in human serum, epidermis, pig adrenals. can also metabolize 7-dehydrocholesterol to produce 7-dehydropregnenolone, which be further modified steroidogenic enzymes generating Δ7-steroids (1,2). Lastly, CYP27A1 act on lumisterol (L3) producing at 9...