A5070623205- Cardiac Imaging and Diagnostics
- Cardiovascular Function and Risk Factors
- Cardiac Valve Diseases and Treatments
- Cardiomyopathy and Myosin Studies
- Cardiac pacing and defibrillation studies
- Acute Myocardial Infarction Research
- Advanced MRI Techniques and Applications
- Cardiac Structural Anomalies and Repair
- Coronary Interventions and Diagnostics
- Cardiac Arrhythmias and Treatments
- Infective Endocarditis Diagnosis and Management
- Cardiovascular Disease and Adiposity
- Atrial Fibrillation Management and Outcomes
- Blood Pressure and Hypertension Studies
- Heart Failure Treatment and Management
- Cardiovascular Effects of Exercise
- Congenital heart defects research
- Cardiovascular Health and Disease Prevention
- Cardiovascular Issues in Pregnancy
- Cardiac, Anesthesia and Surgical Outcomes
- Heart Rate Variability and Autonomic Control
- Neurological disorders and treatments
- Cardiac Health and Mental Health
- Mechanical Circulatory Support Devices
- Antiplatelet Therapy and Cardiovascular Diseases
Mayo Clinic
2016-2025
WinnMed
2017-2025
Mayo Clinic in Arizona
2016-2024
Mayo Clinic Health System
2024
Cleveland Clinic
2021-2024
Harefield Hospital
2017-2023
Imperial College London
2011-2023
Lung Institute
2023
Guy's and St Thomas' NHS Foundation Trust
2023
NIHR Royal Brompton Cardiovascular Biomedical Research Unit
2016-2021
Hypertrophic cardiomyopathy (HCM) exhibits genetic heterogeneity that is dominated by variation in eight sarcomeric genes. Genetic a large number of non-sarcomeric genes has also been implicated HCM but not formally assessed. Here we used very case and control cohorts to determine the extent which contributes HCM.We sequenced known putative new prospective cohort (n = 804) analysed data alongside largest published series clinically genotyped patients 6179), previously reference population...
Angina is common in hypertrophic cardiomyopathy (HCM) and associated with abnormal myocardial perfusion. Wave intensity analysis improves the understanding of mechanics ischemia. was used to describe mechanisms underlying perfusion abnormalities patients HCM. Simultaneous pressure flow were measured proximal left anterior descending artery 33 HCM 20 control at rest during hyperemia, allowing calculation wave intensity. Patients also underwent quantitative first-pass cardiac magnetic...
Background Spontaneous coronary artery dissection (SCAD) is a cause of acute syndrome predominantly in women without usual cardiovascular risk factors. Many have history migraine headaches, but this association poorly understood. This study aimed to determine prevalence among SCAD patients and assess differences clinical factors based on history. Methods Results A cohort was conducted using the Mayo Clinic “Virtual” Multi‐Center Registry composed with as confirmed angiography....
Type 2 myocardial infarction (T2MI) occurs because of an acute imbalance in oxygen supply and demand the absence atherothrombosis. Despite being frequently encountered clinical practice, population-based incidence trends remain unknown, long-term outcomes are incompletely characterized.
Data on the clinical use of left atrial (LA) hemodynamic monitoring during MitraClip procedure are limited. This study evaluated association between intraprocedural changes in LA pressure after and improvement exercise capacity as documented by 6-minute walk test (6MWT).Study population included 50 patients who underwent at Mayo Clinic (Rochester, MN), June 2014 July 2016 completed both baseline 30-day follow-up 6MWT. Primary outcome for current analysis was defined 6MWT above median. Mean...
Left ventricular function can be evaluated by qualitative grading and eyeball estimation of ejection fraction (EF). We sought to define the reproducibility these techniques, how they are affected image quality, experience accreditation. Twenty apical four-chamber echocardiographic cine loops (Online Resource 1-20) varying quality left were anonymized presented 35 operators. Operators asked provide (1) a one-phrase global systolic (2) an "eyeball" EF estimate (3) rating on 0-100 visual...
Left atrial appendage (LAA) closure for stroke prevention in the setting of non-valvular fibrillation is an alternative to oral anticoagulation patients with increased bleeding risk. It allows similar reduction thromboembolic events, particular stroke, compared warfarin. A common clinical dilemma management peri-device leak after LAA occlusion. This has been documented both percutaneous as well surgical approaches. The specific definitions severity, and longer-term implications are poorly...
Background We tested whether biologic age, as estimated by deficits, functional impairments, or Age‐Gap their combination, provide improved estimation of cause‐specific death compared with chronological age. Methods Cardiovascular and noncardiovascular were prospectively collected in 535 patients aged ≥55 years undergoing percutaneous coronary interventions between August 1, 2014, March 31, 2018. was calculated the difference age artificial intelligence ECG using a convolutional neural...
Background: Patients receiving implantable cardioverter‐defibrillators (ICDs) often have severely impaired left ventricular function and a poor prognosis. Having an ICD in situ effectively denies them the possibility of quick, arrhythmic death. It is still unclear if when end life device deactivation should be discussed with patients how much want to know prior implantation. Methods: active for chronic heart failure were interviewed regarding their attitude toward ICD, recollection consent...
Abstract Introduction Hepatic epithelioid hemangioendothelioma is a rare malignancy arising from the vascular endothelial cells within liver. Historically, disease characterized as being poorly responsive to both chemotherapy and radiotherapy, with liver resection or transplantation treatment of choice when feasible. For patients advanced disease, reports long-term therapeutic benefits conventional cytotoxic treatments are very limited. Owing rarity this malignancy, there no structured...
BackgroundIn at-risk patients with left ventricular dysfunction, implantable cardioverter defibrillators (ICDs) prolong life. Implantable are increasingly implanted for primary prevention and therefore into lower risk patients. Trial data have demonstrated the benefit of these devices but does not provide an estimate potential lifespan-gain over longer time periods, e.g. a patient's lifespan.
Hypertrophic cardiomyopathy (HCM) is an important cause of sudden cardiac death associated with heterogeneous phenotypes, but there no systematic framework for classifying morphology or assessing risks. Here, we quantitatively survey genotype-phenotype associations in HCM to derive a data-driven taxonomy disease expression.