A5069432662- Autism Spectrum Disorder Research
- Genetics and Neurodevelopmental Disorders
- Congenital heart defects research
- Neurotransmitter Receptor Influence on Behavior
- Neuroscience and Neuropharmacology Research
- Metabolism and Genetic Disorders
- Receptor Mechanisms and Signaling
- Neurological and metabolic disorders
- Diet and metabolism studies
- Neurogenesis and neuroplasticity mechanisms
Radboud University Nijmegen
2020-2025
Radboud University Medical Center
2020-2025
University Medical Center
2025
Autism-associated CHD8/CHD7/kismet deficiency in blood-brain barrier glia causes developmental hyperserotonemia and sleep defects.
Epilepsy is a mechanistically complex, incompletely understood neurological disorder. To uncover novel converging mechanisms in epilepsy, we used Drosophila whole-brain single-cell RNA-sequencing to refine and characterize previously proposed human epilepsy-associated gene co-expression network (GCN). We identified conserved co-expressed module of 26 genes, which comprises fly orthologs 13 genes integrates synaptic metabolic functions. Over one-third the pan-neuronal knockdown models...
Vulnerability to drug addiction relies on substantial individual differences. We previously demonstrated that serotonin transporter knockout (SERT-/- ) rats show increased cocaine intake and develop signs of compulsivity. However, the underlying neural mechanisms are not fully understood. Given pivotal role glutamate prefrontal cortex in cocaine-seeking behavior, we sought investigate expression proteins implicated neurotransmission naïve cocaine-exposed lacking SERT. focused infralimbic...
Habituation, the most ancient and fundamental form of learning, manifests already before birth. Neuroscientists have been fascinated for decades by its function as a firewall protecting our brains from sensory information overload indispensability higher cognitive processing. Evidence that habituation learning is affected in autism related monogenic neurodevelopmental syndromes their animal models has exponentially grown, but potential this convergence to advance both fields still largely...
Habituation is the most ancient and fundamental form of learning. As a firewall that protects our brain from sensory overload, it indispensable for higher cognitive processes. Studies in humans animal models provide growing body evidence habituation affected autism related monogenic neurodevelopmental disorders (NDDs). An integrated application assessment NDDs their has currently unexploited potential neuroscience medical care.With aim to gain mechanistic insights, we systematically...