A5008887560- Advanced Fluorescence Microscopy Techniques
- Thyroid Cancer Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- Optical Coherence Tomography Applications
- Cancer-related Molecular Pathways
- Cancer, Lipids, and Metabolism
- Nanofabrication and Lithography Techniques
- 3D Printing in Biomedical Research
- Immune Cell Function and Interaction
- Innovative Microfluidic and Catalytic Techniques Innovation
- Immune cells in cancer
- Bioinformatics and Genomic Networks
Brigham and Women's Hospital
2021-2022
Harvard University
2018-2022
Cancer Research Institute
2018-2020
Beth Israel Deaconess Medical Center
2018-2020
Center for Vascular Biology Research
2018
Background: BRAFV600E acts as an ATP-dependent cytosolic kinase. inhibitors are widely available, but resistance to them is reported in the clinic. Lipid metabolism (fatty acids) fundamental for energy and control cell stress. Whether how impacts lipid regulation papillary thyroid carcinoma (PTC) still unknown. Acetyl-CoA carboxylase (ACC) a rate-limiting enzyme de novo synthesis inhibition of fatty acid oxidation (FAO). ACC1 ACC2 genes encode distinct isoforms ACC. The aim our study was...
By observing the activity of anti-cancer agents directly in tumors, there is potential to greatly expand our understanding drug response and develop more personalized cancer treatments. Implantable microdevices (IMD) have been recently developed deliver microdoses chemotherapeutic locally into confined regions live tumors; tissue can be subsequently removed analyzed evaluate response. This method has rapidly screen multiple drugs, but requires surgical removal only evaluates at a single...
Advances in the intratumor measurement of drug responses have included a pioneering biomedical microdevice for high throughput screening vivo, which was further advanced by integrating graded-index lens based two-dimensional fluorescence micro-endoscope to monitor tissue situ across time. While previous system provided bulk both delivery and response from given region tumor, it incapable visualizing distribution three-dimensional (3D) way, thus missing critical relationship between...
Tumor-infiltrating immune cells experience significant metabolic reprogramming in the tumor microenvironment (TME), and they share similar pathways nutrient needs with malignant cells. This positions these cell types direct competition TME. We currently lack a complete understanding of similarities, differences, functional consequences utilized by activated from different lineages versus neoplastic study applies novel situ approach using implantable microdevices to expose 27 controlled...