ABSTRACT Introduction This study aimed to assess programmed death‐1 (PD‐1) and death ligand‐1 (PDL‐1) expression in newly diagnosed pediatric cases of acute B‐lymphoblastic leukemia (B‐ALL) at 6 months treatment explore their value as biomarkers. Methods Fifty B‐ALL patients 30 controls were recruited. Bone marrow samples or peripheral blood obtained from children diagnosis after cytotoxic therapy. Flow cytometric analysis was done the PD‐1, PDL‐1, CD3 (cluster differentiation) expressions...

Disease activity score 28 (DAS28) for rheumatoid arthritis (RA) is the commonly used DAS; it relies on clinical parameters that could be subjective. This work aimed to create a more accurate DAS RA and assess its validity.The study included 98 patients 53 matched controls; they were interviewed, clinically examined, their visual analogue scales (VAS) reported, then blood samples withdrawn erythrocyte sedimentation rate (ESR), complete count (CBC), C-reactive protein (CRP). Platelet indices...

Abstract Background The distress thermometer (DT) is an effective tool for identifying among cancer patients worldwide. However, DT has not been studied in Egyptian patients. We aimed to study the prevalence of with different types cancers using DT. Methods A total 550 newly diagnosed hematological and solid who were followed up at 3 Oncology Centers Egypt enrolled. They completed a sociodemographic clinical status questionnaire, Problem List (PL) scale. Results At cut-off score ≥4, 46% had...

IL27 and IL35 are regulatory T cells (T-regs) related cytokines; they were accused in eukemogenesis of acute myeloid leukemia (AML). This study aimed to assess the expression these cytokines de novo AML investigate their role as biomarkers.Seventy newly diagnosed patients with primary 30 matched healthy volunteers recruited. diagnosis was confirmed flowcytometric immunophenotypic analyses, while ELISA used serum levels controls. Receiver operating characteristic curve analysis estimate...

Background &objectives: Exercise and physical activity are very important for fitness.Exercise could be particularly students as the old proverb stated that "Normal brain exists in normal body".This study was conducted to evaluate effect of body mass index (BMI) on adherence exercise females.Subjects &Methods: Assessment BMI done 3 groups participants, after taking their informed consent then a questionnaire self -administered all participants.Questions were inquire about demographic, social...

Myeloid leukemias (MLs) are clonal stem cell disorders affecting myeloid lineage cells. Advances in cytogenetic and molecular studies partially disclosed the mystery about risk factors pathophysiology of MLs. Regarding incidence, factors, response to treatment, overall survival patients, research showed differences among different countries. However, Western registry data basis for documented description MLs medical textbooks. This aimed study Middle Eastern health centers. Egypt has highest...

Acute myeloid leukemia (AML) is a hematopoietic stem cell disorder that carries very poor prognosis. Understanding molecular basis of AML leukemogenesis could lead to the emergence effective targeted therapies for AML. bearing nucleophosmin (NPM) gene mutation has distinct features. This study was conducted investigate role mutated (m) NPM in pathogenesis de novo through studying its contribution proliferation line cells.Two types human lines were used. One them model AMLs with mNPM and...

A total of 244 patients with hereditary haemolytic anaemias (HHA) were screened for acute symptomatic human parvovirus B19 infection (HPV-B19) in a prospective study. To assess the risks associated HPV-B19 infection, classified into Group I and II according to presence or absence (symptoms, signs specific serology) respectively. In all, 131 (53·7%) had β-thalassaemia, 75 (30·7%) spherocytosis (HS), 27 (11·1%) sickle cell anaemia (SCA) 11 (4·5%) glucose-6-phosphate dehydrogenase (G6PD)...

The sickle cell trait (SCT) disorder possesses a clinical heterogeneity ranging from symptomless condition to sudden death. This study aimed develop diagnostic approach that helps the characterization and identification of SCT normal subjects disease (SCD) patients, assess its severity.Sixty controls, 24 SCD patients 31 were assessed clinically, radiologically by laboratory investigations.Of subjects, 12.8% symptomatic (3.2% anemic, 6.4% hemolytic crisis, 3.2% painful crises). Anemia was...

Platelet indices (PIs) are platelet parameters that correlated with activity. Despite being widely available, inexpensive, and feasible; their use in clinical settings is limited. Recently, we developed a new score (EgyDAS), which relies on PIs assesses disease activity rheumatoid arthritis (RA).This study explored the practicability validity of EgyDAS RA ankle involvement, considering neglected commonly used DAS28 score.This comparative case-control included 2-groups patients, group1...

Abstract Background and objectives Platelet indices are widely available relatively cheap platelet parameters. The critical objective of this study is to assess the reliability as biomarkers for diagnosis prognosis in adult thrombocytopenic patients. Methods A retrospective case–control study, including 81 immune thrombocytopenia (ITP) cases, 50 aplastic anemia (AA) 150 participants a control group. This included patients admitted from 2016 2021 Clinical Hematology Unit, Department Internal...

Aplastic anemia (AA) is a hypoproliferative that led to significant morbidity and mortality. Recently, dramatic improvement in prognosis of AA was achieved; this part due advances immunosuppressive therapy HSCT. Nevertheless, still one the most challenging hematological disorders could face hematologist. This study conducted at Assiut University Hospital (AUH), Assiut, Egypt evaluate current situation future prospective AA. 63 patients with were prospectively enrolled study; they admitted...

Myeloproliferative neoplasms (MPNs) are a group of hematological disorders characterized by proliferation one or more than myeloid lineage. Genetically they express single multiple mutations the Janus tyrosine kinase receptors. Advances in understanding molecular and cytogenetic pathophysiology MPNs led to further identification different rather classical break point cluster region Abelson (BCR-ABL). Although onset disease all is insidious may be asymptomatic, also run slowly progressive...

Background: Sideropenic anemias (SAs) are a group of hypoproliferative characterized by hyposideremia. Although they run an insidiously started slowly progressive course, pointer for underlying serious disease. Fortunately, in most cases, management SAs is available, effective and relatively inexpensive. Splenomegaly was reported patients with variation Hacckett's grading hematological profile. Etiopathogenesis splenomegaly mainly explained as related to the pathologic process anemia or...

Worldwide, about 350 million persons have chronic hepatitis B virus (HBV) infection, and about 125 been infected with C (HCV), putting viral and C among the world's greatest infectious disease health problems. In Saudi Arabia, hepatitis ranked second most common reportable in 2007. The aim of study: was to assess impact educational intervention on knowledge pregnant women toward viral hepatitis & infections, also, know prevalence among laboring Al Dawadmi. Study Design: A...

Abstract Background: The distress thermometer (DT) is an effective tool for identifying among cancer patients worldwide. However, DT has not been studied in Egyptian patients. We aimed to study the prevalence of with different types cancers using DT. Methods: A total 550 newly diagnosed hematological and solid who were followed up at 3 Oncology Centers Egypt enrolled. They completed a sociodemographic clinical status questionnaire, Problem List (PL) scale. Results: At cut-off score ≥4, 46%...

Abstract Background Hemoglobinopathies represent a set of inherited red blood cell (RBCs) disorders, characterized by abnormal hemoglobin molecule. They include qualitative and quantitative hemoglobinopathies, with structurally globin chain in the first defective production later. This study assessed, for time, significance mathematically calculated RBC indices to identify patients hemoglobinopathies from normal subjects or iron deficiency anemia (IDA) differentiate various types each other....

Background: Sideropenic anemias (SAs) are a group of hypoproliferative characterized by hyposideremia. Although they run an insidiously started slowly progressive course, pointer for underlying serious disease. Fortunately, in most cases, management SAs is available, effective and relatively inexpensive. Splenomegaly was reported patients with variation Hacckett's grading hematological profile. Etiopathogenesis splenomegaly mainly explained as related to the pathologic process anemia or...

Since the first transplant in 1957 and hematopoietic stem cell transplantation (HSCT) is curative modality for numerous hematological disorders. Nevertheless, it not available all patients. Besides unavailability of matched donors a lot factors could hinder HSCT resource limited setting, as financial administrative factors. In our daily practice we noticed other that center, common myths misconceptions about donation. This quasi-experimental study assessed, time, among 218 medical nursing...

In our previous work, we provided strong evidence that nucleophosmin (NPM) gene mutation has an important role in leukemogenesis of primary acute myeloid leukemia (AML). Furthermore, speculated a new targeted therapy patients with AML and bearing mutated NPM (mNPM). Based on these results together findings other researchers, it was essential to develop method for accurate detection mNPM.Our based utilizing the most recent flow cytometeric techniques instruments measuring mNPM. Attributed...

Abstract Background The distress thermometer (DT) is an effective tool for identifying among cancer patients worldwide. However, DT has not been studied in Egyptian patients. We aimed to study the prevalence of with different types cancers using DT. Methods A total 550 newly diagnosed hematological and solid who followed at 3 Oncology Centers Egypt were enrolled. They completed a sociodemographic clinical status questionnaire, Problem List (PL) scale. Results At cut off score ≥ 4, 46% had...

Abstract Background: The distress thermometer (DT) is an effective tool for identifying among cancer patients worldwide. However, DT has not been studied in Egyptian patients. We aimed to study the prevalence of with different types cancers using DT. Methods: A total 550 newly diagnosed hematological and solid who were followed up at 3 Oncology Centers Egypt enrolled. They completed a sociodemographic clinical status questionnaire, Problem List (PL) scale. Results: At cut-off score ≥4, 46%...