A5019505522- Chronic Lymphocytic Leukemia Research
- Immunotherapy and Immune Responses
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Acute Myeloid Leukemia Research
- Chronic Myeloid Leukemia Treatments
- Cell Adhesion Molecules Research
- Clinical Laboratory Practices and Quality Control
- Digital Imaging for Blood Diseases
- Blood Coagulation and Thrombosis Mechanisms
- Monoclonal and Polyclonal Antibodies Research
- Vitamin K Research Studies
- Lymphoma Diagnosis and Treatment
- AI in cancer detection
- Glycosylation and Glycoproteins Research
- Immune Cell Function and Interaction
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Hematological disorders and diagnostics
- T-cell and B-cell Immunology
- Eosinophilic Disorders and Syndromes
- Chemokine receptors and signaling
- Hemoglobinopathies and Related Disorders
- Prion Diseases and Protein Misfolding
- Platelet Disorders and Treatments
- Acute Lymphoblastic Leukemia research
- X-ray Diffraction in Crystallography
Manchester Royal Infirmary
2012-2023
Manchester University NHS Foundation Trust
2015-2023
University of Manchester
2013-2023
Cancer Research UK Manchester Institute
2011-2023
Foundation University Medical College
2016
King Saud University
2016
King Abdulaziz Medical City
2016
Universitat Politècnica de Catalunya
2016
Achievers University
2016
National Health Service
2015
Summary These guidelines provide information on how to reliably and consistently report abnormal red blood cells, white cells platelets using manual microscopy. Grading of nomenclature a brief description the are provided. It is important that all countries in world use consistent reporting cells. An international group morphology experts have decided these consensus opinion. For some cell abnormalities, it was parameters produced by automated haematology analyser might be more accurate less...
Triazole-capped α-aminoisobutyric acid (Aib) octameric foldamers formed very active ion channels in phospholipid bilayers after the addition of copper(<sc>ii</sc>) chloride, with activity “turned off” by extraction.
Key Points Platelet-poor plasma clotting and fibrinolysis assays detect bleeding tendency in patients with factor XI deficiency. Contact pathway inhibition corn trypsin inhibitor increases sensitivity of these to tendency.
Summary We report the results of a pilot study assessing use digital ‘virtual slides’ in haematological quality assessment. Conducted together with UK National External Quality Assessment Scheme for General Haematology, involved 166 separate participants, using format typical assessment exercise. The revealed substantial concordance observations made slides those reported previous glass slide surveys that used identical cases. Participant feedback strongly supported electronic teaching and...
The laboratory interpretation of blood film morphology is frequently a rapid, accurate, and cost-effective final-stage count analysis. However, the findings often rests with single individual, errors can carry significant impact. Cell identification classification skills are well supported by existing resources, but contribution importance other less understood.The UK external quality assurance group in haematology (UK NEQAS(H)) runs Continued Professional Development scheme where large...
Abstract CXC chemokine receptor 4 (CXCR4) is overexpressed by a broad range of hematological disorders, and its interaction with ligand 12 (CXCL12) central importance in the retention chemoprotection neoplastic cells bone marrow lymphoid organs. In this article, we describe biological evaluation new CXCR4-targeting -antagonizing molecule (BAT1) that designed show that, when incorporated into liposomal drug delivery system, it can be used to deliver cancer therapeutics at high levels chronic...
Chronic lymphocytic leukemia (CLL) is a common hematopoietic malignant disease with variable outcome. CLL has been divided into distinct groups based on whether somatic hypermutation occurred in the region of immunoglobulin heavy-chain locus or alternatively if cells express higher levels CD38 protein. We have analyzed proteome 12 cases (six mutated (M-CLL) and six unmutated (UM-CLL) loci; seven CD38-negative five CD38-positive) using two-dimensional electrophoresis mass spectrometry....
In chronic myeloid leukemia (CML) cells from different stages of maturation may have differential expression BCR-ABL at both messenger RNA (mRNA) and protein level. However, the significance such to clinical disease behavior is unknown. Using CML-derived, expressing cell line, K562, distinct plastic-adherent (K562/Adh) nonadherent (K562/NonAdh) subpopulations were established then analyzed as single bulk populations. mRNA was upregulated in K562/Adh compared with K562/NonAdh population...
Introduction Previous guidelines recommend that FXI :C levels should be used to monitor replacement in factor XI ( ) deficiency. However, do not correlate with bleeding tendency this disorder and may the optimal test by which determine further treatment postoperative period. Aim To assess whether thrombin generation assay TGA rotational thromboelastometry can peri‐operatively deficiency if changes clot formation parameters following solvent‐detergent fresh frozen plasma SD ‐ FFP ). Methods...
Introduction The absence of a reliable clinical test to predict bleeding tendency leaves factor XI ( FXI )‐deficient individuals at risk overtreatment or under treatment. Aim To assess whether rotational thromboelastometry has value in detection deficiency and identification tendency. Methods Thromboelastometry was measured whole blood platelet‐rich plasma PRP ) samples containing corn trypsin inhibitor CTI from controls n = 50) ‐deficient 93) tissue TF 0.12 p m . effect plasminogen...
Background: Morphological examination of blood films remains the reference standard for malaria diagnosis. Supporting skills required to make an accurate morphological diagnosis is therefore essential. However, providing support across different countries and environments a substantial challenge.