A5046227343- Chronic Lymphocytic Leukemia Research
- Lymphoma Diagnosis and Treatment
- Clinical Laboratory Practices and Quality Control
- Visual perception and processing mechanisms
- AI in cancer detection
- Glycosylation and Glycoproteins Research
- Chronic Myeloid Leukemia Treatments
- Viral-associated cancers and disorders
- Immunotherapy and Immune Responses
- Digital Imaging for Blood Diseases
- Colorectal Cancer Screening and Detection
- Chemokine receptors and signaling
- Calcium signaling and nucleotide metabolism
- Tactile and Sensory Interactions
- Semantic Web and Ontologies
- Neuroendocrine Tumor Research Advances
- RNA modifications and cancer
- Monoclonal and Polyclonal Antibodies Research
- Cognitive and developmental aspects of mathematical skills
- Acute Lymphoblastic Leukemia research
- Spatial Neglect and Hemispheric Dysfunction
- Blood groups and transfusion
- Mast cells and histamine
- Sleep and Wakefulness Research
- Visual Attention and Saliency Detection
University of Plymouth
2014-2021
University Hospitals Plymouth NHS Trust
2015-2021
Hospital for Sick Children
2019
Plymouth Hospital
2015
University of Leicester
2011-2015
University of Manchester
2008-2014
St Mary's Hospital
2014
Derriford Hospital
2014
Cancer Research UK Manchester Institute
2011
Manchester Academic Health Science Centre
2009
Summary We report the results of a pilot study assessing use digital ‘virtual slides’ in haematological quality assessment. Conducted together with UK National External Quality Assessment Scheme for General Haematology, involved 166 separate participants, using format typical assessment exercise. The revealed substantial concordance observations made slides those reported previous glass slide surveys that used identical cases. Participant feedback strongly supported electronic teaching and...
Abstract CXC chemokine receptor 4 (CXCR4) is overexpressed by a broad range of hematological disorders, and its interaction with ligand 12 (CXCL12) central importance in the retention chemoprotection neoplastic cells bone marrow lymphoid organs. In this article, we describe biological evaluation new CXCR4-targeting -antagonizing molecule (BAT1) that designed show that, when incorporated into liposomal drug delivery system, it can be used to deliver cancer therapeutics at high levels chronic...
Mature dendritic cells (DCs) may be derived from the BCR/ABL1 expressing monocytes in chronic myeloid leukaemia. These have potential therapeutic applications, but are recognised to defective function. In normal DCs, activation and maturation depend on ABL1 dependent signals. We therefore tested hypothesis that DCs of leukaemia, presence molecule disrupts signal pathways, contributes observed functional defects cells.We employed vitro culture clinical samples, combining microscopic...
Summary Two distinct groups of chronic lymphocytic leukaemia (CLL) are distinguished by the presence or absence somatic hypermutation immunoglobulin heavy‐chain gene. CLL without hypermuataion has an adverse outcome, but precise biological differences that underlie this more aggressive clinical‐course unclear. Using a proteomic approach, we found two prognostic forms were consistently according to their protein expression pattern. The most important difference observed related different...
Mantle cell lymphoma (MCL) is a rare and aggressive form of non-Hodgkin's lymphoma. It can follow heterogeneous clinical course but generally patients relapse early after standard immunochemotherapy regimens develop resistance to subsequent therapies. For younger patients, intensive approaches followed by autologous stem transplantation offer excellent long-term disease control with the possible exception an allogenic transplant, MCL incurable condition. As principally affects older...
Those stimuli that together promote the survival, differentiation and proliferation of abnormal B-lymphocytes chronic lymphocytic leukaemia (CLL) are encountered within tissues, where they form growth-supporting microenvironment. Different tissue-culture systems survival neoplastic lymphocytes from CLL, partly replicating in vivo tissue environment disorder. In present study, we focussed on initial adaptive changes to culture focussing particularly migratory behaviour cellular interactions....
A 79-year-old male had anaemia and apparent thrombocytosis on routine blood analysis (haemoglobin 10·6 g/dl, white cell (WBC) count 2·7 × 109/l, platelet 916 109/l); however, when analysed an optical analyser, the true was found to be low 10·9 WBC 2·8 79 109/l). The thrombocythaemia due multiple needle-like crystals that formed as sample cooled (the upper left panel shows freshly collected with early crystal formation, right prominent appearing allowed cool). Immunological investigation...
Background The recognition and interpretation of abnormal blood cell morphology is often the first step in diagnosing underlying serious systemic illness or leukemia. Supporting staff who interpret film therefore essential for a safe laboratory service. This paper describes an open-access, web-based decision support tool, developed by authors to morphological diagnosis, arising from earlier studies identifying mechanisms error reporting. effectiveness this intervention was assessed using...
Older adults' performance is known to be impaired when they perform secondary or interleaved tasks, compared performing those tasks alone. It not known, however, whether this impairment extends simple low-level motion discriminations. We investigated a task would affect coherence thresholds in both older and younger participants. Coherence (79% correct) were measured for judging the direction of translational global (3.4% contrast) young (<25 yrs) elderly (>65 Simultaneous with stimulus up...
Logarithmic reading charts provide standardized measures of performance. Here we show that existing equivalent assessments visual aspects are in good agreement with traditional acuity and seem uninfluenced by cognitive (linguistic) factors.The aims this study were to (1) determine the equivalence logarithmic sentence word reading, (2) evaluate relationship between chart performance more assessment, (3) establish influence linguistic factors on performance.In a sample 82 normally sighted...
<sec> <title>BACKGROUND</title> The recognition and interpretation of abnormal blood cell morphology is often the first step in diagnosing underlying serious systemic illness or leukemia. Supporting staff who interpret film therefore essential for a safe laboratory service. This paper describes an open-access, web-based decision support tool, developed by authors to morphological diagnosis, arising from earlier studies identifying mechanisms error reporting. effectiveness this intervention...