A5038878885- Sleep and Wakefulness Research
- Sleep and related disorders
- Obstructive Sleep Apnea Research
- Restless Legs Syndrome Research
- Parkinson's Disease Mechanisms and Treatments
- Neuroscience of respiration and sleep
- Acute Ischemic Stroke Management
- Circadian rhythm and melatonin
- Stroke Rehabilitation and Recovery
- Noise Effects and Management
- Sleep and Work-Related Fatigue
- Cardiovascular and Diving-Related Complications
- EEG and Brain-Computer Interfaces
- Traumatic Brain Injury Research
- Amyotrophic Lateral Sclerosis Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Dysphagia Assessment and Management
- Vestibular and auditory disorders
- Dementia and Cognitive Impairment Research
- Cerebrovascular and Carotid Artery Diseases
- Air Quality and Health Impacts
- Vehicle Noise and Vibration Control
- Tracheal and airway disorders
- Autoimmune Neurological Disorders and Treatments
- Myasthenia Gravis and Thymoma
Sunnybrook Health Science Centre
2016-2025
Health Sciences Centre
2016-2025
Sunnybrook Research Institute
2016-2025
University of Toronto
2016-2025
Sunnybrook Hospital
2021-2023
University of Ottawa
2022
Ottawa Hospital
2022
Royal College of Physicians and Surgeons of Canada
2021
Neurology, Inc
2020
Hospital for Sick Children
2019
Emerging studies have implicated air pollution in the neurodegenerative processes. Less is known about influence of pollution, especially at relatively low levels, on developing dementia. We conducted a population-based cohort study Ontario, Canada, where concentrations pollutants are among lowest world, to assess whether exposure associated with incident The population comprised all Ontario residents who, 1 April 2001, were 55–85 years old, Canadian-born, and free physician-diagnosed...
Background and Purpose— In stroke patients, obstructive sleep apnea (OSA) is associated with poorer functional outcomes than in those without OSA. We hypothesized that treatment of OSA by continuous positive airway pressure (CPAP) patients would enhance motor, functional, neurocognitive recovery. Methods— This was a randomized, open label, parallel group trial blind assessment performed rehabilitation unit. Patients were assigned to standard alone (control group) or CPAP (CPAP group). The...
Health Canada, in collaboration with Statistics and other external experts, conducted the Community Noise Study to better understand impacts of wind turbine noise (WTN) on health well-being. A cross-sectional epidemiological study was carried out between May September 2013 southwestern Ontario Prince Edward Island 1238 randomly selected participants (606 males, 632 females) aged 18-79 years, living 0.25 11.22 km from operational turbines. Calculated outdoor WTN levels at dwelling reached 46...
Functional outcome after stroke is often only evaluated using the modified Rankin Scale, which primarily assesses activities of daily living. Stroke patients may experience difficulties with social reintegration and mental functions, feel isolated, poor quality life, even physical recovery complete. assessments based solely on activity limitations not be able to capture full range problems experienced by survivors.Telephone interviews were conducted 2 3 years poststroke assess multiple...
Sleep loss in attending physicians has an unclear effect on patient outcomes. In this study, we examined the of medical care provided by after midnight outcomes their scheduled elective procedures performed during day.We conducted a population-based, retrospective, matched-cohort study Ontario, Canada. Patients undergoing 1 12 daytime physician who had treated patients from to 7 a.m. were matched 1:1 ratio same procedure day when not midnight. Outcomes included death, readmission,...
To test the hypothesis that enlarged Virchow-Robin space volumes (VRS) are associated with objective measures of poor quality sleep. Retrospective cross-sectional study. Sunnybrook Health Sciences Centre. Twenty-six patients being evaluated for cerebrovascular disease were assessed using polysomnography and high-resolution structural magnetic resonance imaging. Regionalized VRS quantified from three-dimensional imaging correlated polysomnography-derived sleep parameters while controlling...
Despite recent studies linking air pollution to neurodegenerative illness, evidence relating and Parkinson's disease (PD) remains scarce. We conducted a population-based cohort study in Ontario, Canada, determine the association between incident PD.Using health administrative databases, we identified all adults aged 55-85 years, free of PD, who lived Ontario on 1 April 2001 (∼2.2 million). Individuals were followed up until 31 March 2013. derived long-term average exposures fine particulate...
Asking for assistance from a teacher is generally viewed by elementary school students as way of avoiding rather than resolving peer conflict. However, there are situations when it appropriate and perhaps necessary to seek help. This study investigated such situations. Vignettes that portrayed aggressive conflict at were presented 128 3rd 4th graders, who asked what they would do why. Students' self-perceptions relations also measured. At Grade 3, boys girls equally likely go the help,...
Abstract Animal studies suggest that rapid eye movement (REM) sleep is governed by the interaction of REM‐promoting and REM‐inhibiting nuclei in pontomesencephalic tegmentum. The pedunculopontine nucleus proposed to be REM promoting. Using polysomnography, we studied five parkinsonian patients undergoing unilateral deep brain stimulation (DBS). We demonstrated a near doubling nocturnal between DBS “off” “on” states, without significant changes other states. This represents first...
Ponto-geniculo-occipital (PGO) waves are phasic pontine, lateral geniculate, and cortical field potentials occurring during before REM sleep that proposed to mediate a wide variety of related neural processes. We sought identify characterize human PGO waves. recorded simultaneously from intrapontine depth electrodes scalp in subject across states. Tertiary care neurological neurosurgical referral center. studied patient involved study the clinical effects unilateral pedunculopontine nucleus...
Background and Purpose— Intravenous tissue plasminogen activator for ischemic stroke is approved eligible patients who can be treated within a 3-hour window, but treatment rates remain disappointingly low, often <5%. To improve rapid access to thrombolysis in Toronto, Canada, citywide prehospital acute activation protocol was implemented by the provincial government transport directly one of 3 regional centers, bypassing local hospitals. This comprised paramedic screening tool, ambulance...
Objective: To longitudinally examine objective and self-reported outcomes for recovery of cognition, communication, mood participation in adults with traumatic brain injury (TBI) co-morbid post-traumatic sleep/wake disorders.
To investigate the association between self-reported and objective measures of sleep wind turbine noise (WTN) exposure.
In 2010, a safety signal was detected for narcolepsy following vaccination with Pandemrix, an AS03-adjuvanted monovalent pandemic H1N1 influenza (pH1N1) vaccine. To further assess possible association and inform policy on future use of adjuvants, we conducted multi-country study adjuvanted pH1N1 vaccines. We used electronic health databases to conduct dynamic retrospective cohort incidence rates (IR) before during virus circulation, after campaigns in Canada, Denmark, Spain, Sweden, Taiwan,...
Background: Independence and reintegration into community roles are important patient-centered outcomes after stroke. Depression cognitive impairment common post-stroke conditions that may impair long-term function even years a However, screening for these comorbidities remains infrequent in stroke prevention clinics the utility of this predicting higher-level has not been evaluated. Aims: To evaluate ability validated brief Depression, Obstructive sleep apnea, Cognitive screen (DOC screen)...
Abstract Background: To examine the association between severity of obstructive sleep apnea (OSA) and nocturnal hypoxemia with incident cancer. Methods: This was a multicenter retrospective clinical cohort study using linked provincial health administrative data on consecutive adults who underwent diagnostic 1994 2017 in four academic hospitals (Canada) were free cancer at baseline. Cancer status derived from Ontario Registry. Cox cause–specific regressions utilized to address objective...
When schoolchildren are harassed by peers, it sometimes is necessary to seek help from a teacher. However, students and teachers may have different sense of when necessary. The authors investigated students' perceptions harassment seeking, examining whether related popularity differ. Fourth- 5th-grade (classified as popular, average, or unpopular) were interviewed about types harassment. Unpopular children perceived teasing more seriously than other children; in fact, they said that serious...