A5100643218- Lymphoma Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- CAR-T cell therapy research
- Multiple Myeloma Research and Treatments
- Cancer Genomics and Diagnostics
- T-cell and Retrovirus Studies
- Acute Myeloid Leukemia Research
- Viral-associated cancers and disorders
- Immunodeficiency and Autoimmune Disorders
- CNS Lymphoma Diagnosis and Treatment
- Cutaneous lymphoproliferative disorders research
- Vector-Borne Animal Diseases
- Immune Cell Function and Interaction
- Hematopoietic Stem Cell Transplantation
- Protein Degradation and Inhibitors
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Cancer Treatment and Pharmacology
- Acute Lymphoblastic Leukemia research
- Animal Disease Management and Epidemiology
- Mast cells and histamine
- Neutropenia and Cancer Infections
- Peptidase Inhibition and Analysis
- Lung Cancer Treatments and Mutations
- Histone Deacetylase Inhibitors Research
- Urticaria and Related Conditions
Institut Gustave Roussy
2016-2025
Laboratoire d'études sur les monothéismes
2023
Université Paris-Saclay
2017-2022
Inserm
2012-2022
Université Paris-Sud
2017
La Ligue Contre le Cancer
2017
Service de la Santé Publique
2013
Université Paris Cité
2006-2012
Délégation Paris 5
2008-2012
Centre National de la Recherche Scientifique
2004-2012
Human T-cell lymphotropic virus type 1 (HTLV-1) is transmitted through a viral synapse and enters target cells via interaction with the glucose transporter GLUT1. Here, we show that Neuropilin-1 (NRP1), receptor for semaphorin-3A VEGF-A165 member of immune synapse, also physical functional partner HTLV-1 envelope (Env) proteins. Env NRP1 complexes are formed in cotransfected cells, endogenous contributes to binding cells. overexpression increases Env-dependent syncytium formation. Moreover,...
Adult's mastocytosis is usually associated with persistent systemic involvement and c-kit 816 mutation, while pediatrics disease mostly limited to the skin often resolves spontaneously. We prospectively included 142 adult patients histologically proven mastocytosis. compared phenotypic genotypic features of adults whose started during childhood (Group 1, n = 28) those at adult's age 2, 114). Genotypic analysis was performed on biopsy by sequencing exons 17 8 13. According WHO classification,...
Background Indolent forms of mastocytosis account for more than 90% all cases, but the types and type severity symptoms their impact on quality life have not been well studied. We therefore performed a case-control cohort study to examine self-reported disability in patients with mastocytosis. Methodology/Principal Findings In 2004, 363 90 controls France were asked rate overall (OPA score) 38 individual symptoms. The latter was used calculate composite score (AFIRMM score). Of respondents,...
The intestinal microbiota plays a key role in the pathogenesis of acute graft-versus-host disease (aGVHD). High-dose conditioning regimens given prior to allogeneic hematopoietic stem cell transplantation (aHSCT) modulate composition gut and damage epithelial barrier, resulting increased systemic inflammation. We assessed whether decontamination with antibiotics (ATB) aHSCT influenced frequency aGVHD mortality 500 patients from two Canadian centers between 2005 2012. rate grade II–IV was...
Abstract Purpose: IL6 is important for the growth and survival of myeloma cells. This study evaluated blocking with siltuximab to delay transition from high-risk smoldering multiple (SMM) myeloma. Patients Methods: In a randomized, double-blind, placebo-controlled, multicenter study, 85 patients SMM were randomized 15 mg/kg (43 patients) or placebo (42 patients). The primary endpoint was 1-year progression-free (PFS) rate, based on IMWG CRAB criteria. Secondary endpoints included progressive...
Abstract The purpose of this study is to describe the clinical and prognostic features evaluate outcome different therapeutic approaches among patients with blastic plasmacytoid dendritic cell neoplasm (BPDCN) who have been diagnosed treated in institutions. A total 398 from 75 centers were included study. Treatment consisted non-Hodgkin lymphoma (NHL)–like regimens 129 (32.8%) acute leukemia (AL)–like 113 (23.5%) patients. In 61 (15.5%) 16 (4.1%) patients, chemotherapy was followed by...
ABSTRACT Detection of galactomannan antigen (GMA) in serum is the standard assay for diagnosis invasive aspergillosis (IA) high-risk patients with hematological disorders. Aspergillus DNA has been proposed, but its sensitivity lower than that GMA when small volumes (SSV) are used. In this study, we investigated whether extraction from large (LSV) improves diagnostic yield. a 13-month prospective compared performances twice-weekly screening by an enzyme immunoassay and weekly fumigatus...
Hairy cell leukaemia (HCL) is a rare haematological malignancy, with approximately 175 new incident cases in France. Diagnosis based on careful examination of the blood smear and immunophenotyping tumour cells, panel four markers being used specifically to screen for hairy cells (CD11c, CD25, CD103 CD123). In 2011, V600E mutation BRAF gene exon 15 was identified HCL; present HCL, it absent variant form HCL (HCL-v) splenic red pulp lymphoma (SRPL), two entities related HCL. The management...
The Bruton tyrosine kinase inhibitor ibrutinib has become a leading therapy against chronic lymphoid leukemia. Recently, been associated with the occurrence of invasive fungal infections, in particular aspergillosis. mechanisms underlying increased susceptibility to infections exposure are currently unknown. Innate immunity, polymer-phonuclear neutrophils, represents cornerstone anti-Aspergillus immunity; however, potential impact on neutrophils little studied. Our study investigated...
ABSTRACT Introduction We retrospectively analysed bortezomib–dexamethasone–rituximab (BDR) combination in patients with Waldenström macroglobulinaemia (WM) a real world setting. Methods A total of 87 were included: 49 (56%) treated frontline, 22 (25%) second line and 16 (19%) third or further settings. log‐rank test was used to compare overall event‐free survival (OS EFS) whereas Gray's performed cumulative incidence deaths relapse (CID CIR) according the IPSS‐WM groups, MYD88/CXCR4...
We assessed the long-term results of autologous stem-cell transplantation for patients with first-relapsed or refractory Hodgkin lymphoma included in prospective Lymphoma Study Association/Société Française de Greffe Moelle H96 trial. This large multicenter phase II trial evaluated a risk-adapted strategy single tandem 245 patients. Poor-risk (n=150) had primary (n=77) ≥2 risk factors at first relapse (n=73) and were eligible transplantation. Intermediate-risk (n=95) one factor With median...
Rapamycin, an inhibitor of mammalian target rapamycin kinase, is a potent immunosuppressive drug that also displays antineoplastic properties and expands regulatory T cells. Steroid-refractory acute graft-versus-host disease (GVHD) remains significant cause mortality after allogeneic stem-cell transplantation therapeutic options are not codified. We retrospectively evaluated the role in this setting.In retrospective single-center study, 22 patients were identified, from October 2004 to...
ABSTRACT Hormographiella aspergillata , a filamentous basidiomycete, has rarely been involved in human infections. We describe 2 febrile neutropenic patients who developed severe pulmonary infection due to H. while receiving empirical caspofungin therapy for presumed fungal pneumonia. After introduction of liposomal amphotericin B, one patient, had neutrophil recovery, presented favorable outcome, the other, remained throughout course infection, died. Resistant fungi, including...
Suboptimal levels of antiretroviral drugs result in virologic failure HIV-infected patients treated with highly active therapy (HAART).To assess the relationship between indinavir hair and outcome.Cross-sectional study.7 AIDS clinics France.89 who received HAART that included indinavir.Patients were classified as responders or nonresponders on basis viremia at time collection. In nonresponders, resistance mutations protease gene assessed baseline measurement.Mean (+/-SD) significantly higher...
Quantification of peripheral blood (PB) CD34+ cells is commonly used to plan progenitor cell (PBPC) collection but time-consuming. Sysmex has developed a hematology analyzer that can quickly identify population immature hematopoietic (HPCs) according size, density, and differential lysis resistance, which may indicate the presence PBPCs in PB. This prospective study evaluated potential such method predict PBPC mobilization.A total 141 patients underwent mobilization. PB HPCs were...