A5045544414- Immunotherapy and Immune Responses
- Mitochondrial Function and Pathology
- T-cell and B-cell Immunology
- CAR-T cell therapy research
- Genetics, Aging, and Longevity in Model Organisms
- Cancer Immunotherapy and Biomarkers
- Endoplasmic Reticulum Stress and Disease
- Lipid metabolism and biosynthesis
- Anesthesia and Neurotoxicity Research
- Intensive Care Unit Cognitive Disorders
- Immune Response and Inflammation
- CRISPR and Genetic Engineering
- Advanced Fluorescence Microscopy Techniques
- Neuroinflammation and Neurodegeneration Mechanisms
- Cancer Cells and Metastasis
- vaccines and immunoinformatics approaches
- Immune Cell Function and Interaction
The University of Texas Southwestern Medical Center
2021-2024
Jackson Laboratory
2021
Baylor University
2014
Abstract Dendritic cells (DCs) play the central role in priming of naive T and differentiation unique effector cells. In this study, using lung tissues blood from both humans humanized mice, we analyzed response human CD1c+ CD141+ DC subsets to live-attenuated influenza virus. Specifically, type CD4+ cell immunity elicited by virus–exposed DCs. Both induce proliferation allogeneic with capacity secrete IFN-γ. However, DCs are uniquely able IL-4– IL-13–producing IL-13–secreting through OX40...
Abstract The mechanisms by which microbial vaccines interact with human APCs remain elusive. Herein, we describe the transcriptional programs induced in DCs pathogens, innate receptor ligands and vaccines. Exposure of to influenza, Salmonella enterica Staphylococcus aureus allows us build a modular framework containing 204 transcript clusters. We use this characterize responses monocytes, monocyte-derived blood DC subsets 13 Different induce distinct based on pathogen type, adjuvant...
Concussion is associated with a myriad of deleterious immediate and long-term consequences. Yet the molecular mechanisms genetic targets promoting selective vulnerability different neural subtypes to dysfunction degeneration remain unclear. Translating experimental models blunt force trauma in C. elegans concussion mice, we identify conserved neuroprotective mechanism which reduction mitochondrial electron flux through complex IV suppresses trauma-induced highly vulnerable dopaminergic...
Metastasis of melanoma significantly worsens prognosis; thus, therapeutic interventions that prevent metastasis could improve patient outcomes. Here, we show using humanized mice colonization distant visceral organs with is dependent upon a human CD33+CD11b+CD117+ progenitor cell subset comprising <4% the CD45+ leukocytes. Metastatic tumor-infiltrating CD33+ cells from patients and (h)NSG-SGM3 showed converging transcriptional profiles. Single-cell RNA-seq analysis identified gene...
Yu, C. I., Becker, P. Metang, F. Marches, Y. Wang, H. Toshiyuki, J. Banchereau, M. Merad, and A. K. Palucka. 2014. Human CD141+ dendritic cells induce CD4+ T to produce type 2 cytokines. Immunol. 193: [4335–4343][1]. The sixth author’s name was published incorrectly. The correct
Neurons deploy diverse adaptive strategies to ensure survival and neurotransmission amid cellular stress. When these pathways are overwhelmed, functional impairment or neurodegeneration follows. Here we show that stressed neurons actively induce a state of transmissive dormancy as protective measure. Extending observations neurotrauma in C. elegans mice, human dopaminergic capable surviving severe challenges both decrease spontaneous activity modulate dopamine homeostasis through the...
Abstract Metastasis is a major risk factor for poor melanoma outcome, but mechanisms supporting distant organ colonization by are not fully understood. Here, we found that metastatic tumors from patients infiltrated CD33+ myeloid cells. To determine the role of cells in metastasis, used NSG mice humanized engraftment human CD34+ hematopoietic progenitor and transgenic expression cytokines SCF/GM-CSF/IL-3 (SGM3). Humanized (h)NSG-SGM3 enabled development bone marrow peripheral tissues, when...