A5050768539- Mesenchymal stem cell research
- Wound Healing and Treatments
- 3D Printing in Biomedical Research
- Electrospun Nanofibers in Biomedical Applications
- Innovative Microfluidic and Catalytic Techniques Innovation
- Hydrogels: synthesis, properties, applications
- Glaucoma and retinal disorders
- Angiogenesis and VEGF in Cancer
- Curcumin's Biomedical Applications
- Microfluidic and Bio-sensing Technologies
- Diabetic Foot Ulcer Assessment and Management
- Retinal Diseases and Treatments
- Retinal Development and Disorders
- RNA Interference and Gene Delivery
Centre of Excellence in Molecular Biology
2019-2023
Pakistan Council of Scientific & Industrial Research
2023
University of the Punjab
2019-2022
Brigham and Women's Hospital
2019-2020
Harvard University
2019-2020
Abstract Current in vitro antitumor drug screening strategies insufficiently mimic biological systems. They tend to lack true perfusion and draining microcirculation systems, which may post significant limitations explicitly reproducing the transport kinetics of cancer therapeutics. Herein, fabrication an improved tumor model consisting a bioprinted hollow blood vessel lymphatic pair, hosted 3D microenvironment‐mimetic hydrogel matrix is reported, termed as tumor‐on‐a‐chip with pair...
There has been an increasing demand for bioengineered blood vessels utilization in both regenerative medicine and drug screening. However, the availability of a true vascular graft remains limited. Three-dimensional (3D) bioprinting presents potential approach fabricating or vascularized tissue constructs various architectures sizes transplantation regeneration. In this review, we summarize basic biology different vessels, as well 3D approaches bioink designs that have applied to fabricate...
Following recent findings from our group that curcumin preconditioning augments the therapeutic efficacy of adipose-derived stem cells in healing diabetic wounds rats, we aimed to investigate regenerative effects preconditioned mesenchymal (ASCs) for better recovery acid inflicted burns this study.ASCs were with 5 μM 24 hours and assessed proliferation, migration, paracrine release potential gene expression comparative naïve ASCs. Subsequently, capacity ASCs (Cur-ASCs) versus was examined...
The therapeutic effectiveness of stem cells after transplantation is hampered by the hypoxic milieu chronic wounds. Prior research has established antioxidant priming as a thorough plan to improve cell performance. purpose this study was ascertain how caffeic acid (CA) affected ability human adipose-derived (hASCs) function under stress. In order cytoprotective properties CA, hASCs were primed with CA in CoCl
DOI: 10.1002/adfm.201807173 In the original version of this article in Figure 6B, right panels were accidentally placed redundancy with left panels. Upon further understanding issue, it was identified that for specific set data, microscopy images not saved correctly leading to same being collected 6B panel at time points 60 min, 12 h, and 24 h. This error is now corrected updated 6, where entire (including point 5 min) have been replaced an independent data experimental group. These errors...
To delineate the genetic bases of primary congenital glaucoma (PCG), we ascertained a large cohort consisting 48 consanguineous families. Of these, previously reported 26 families with mutations in CYP1B1 and six LTBP2, whereas responsible for PCG 16 remained elusive. We employed next-generation whole exome sequencing to basis four these familial cases. Exclusion linkage loci was established followed by sequencing, which performed on 10 affected individuals manifesting cardinal systems...
Aim: Pretreatment of stem cells with antioxidants accelerates their ability to counter oxidative stress and is associated the overall therapeutic outcome transplantation. Material & methods: Wharton Jelly derived mesenchymal (WJMSCs) were cultured pretreated various doses antioxidants; Vitamin C (Vit C), E E), D3 D3) Cocktail, followed by exposure in vitro heat injury. Assessment WJMSCs survival, paracrine release, wound healing expression angiogenic survival markers was conducted. Results:...
In article number 1807173, Yu Shrike Zhang and co-workers report the development of an improved tumor-on-a-chip model consisting a bioprinted hollow, perfusable blood vessel for liquid delivery single end-blinded lymphatic interstitial fluid draining, hosted in 3D tumor microenvironment-like hydrogel matrix. This featuring biomimetic local microcirculation exhibits well-controlled transport biomolecules anti-cancer drugs.