A5033500430- Wound Healing and Treatments
- Mesenchymal stem cell research
- Electrospun Nanofibers in Biomedical Applications
- Hydrogels: synthesis, properties, applications
- Tissue Engineering and Regenerative Medicine
- Diabetic Foot Ulcer Assessment and Management
- Liver physiology and pathology
- Nanoparticles: synthesis and applications
- Pancreatic function and diabetes
- Osteoarthritis Treatment and Mechanisms
- Silk-based biomaterials and applications
- Graphene and Nanomaterials Applications
- Peroxisome Proliferator-Activated Receptors
- Advanced Drug Delivery Systems
- Metabolism, Diabetes, and Cancer
- Exercise and Physiological Responses
- Adipose Tissue and Metabolism
- Liver Disease Diagnosis and Treatment
- Heavy metals in environment
- Mechanical Circulatory Support Devices
- Natural Antidiabetic Agents Studies
- Curcumin's Biomedical Applications
- Mangiferin and Mango Extracts
- Polysaccharides Composition and Applications
- Angiogenesis and VEGF in Cancer
Centre of Excellence in Molecular Biology
2015-2024
University of the Punjab
2015-2024
National University of Sciences and Technology
2011
Decline in the function of stem cells with age, such as other body, results an imbalance between loss and renewal. Increasing age donor thus diminishes effectiveness MSCs (mesenchymal cells) transplantation age-related diseases. The clinical use cell therapies needs autologous transplantation; it is essential therefore to study repair ability survivability before transplantation. Bone marrow derived possess multi-lineage differentiation potential, but aging adversely affects their...
Oxidative stress is a major obstacle against cartilage repair in osteoarthritis (OA). Anti-oxidant agents can play vital role addressing this issue. We evaluated the effect of Vitamin E preconditioning improving potential mesenchymal stem cells (MSCs) to confer resistance oxidative prevailing during OA.Vitamin pretreated MSCs were exposed vitro by hydrogen peroxide (H2O2) and also implanted surgically-induced rat model OA. Analysis was done terms cell proliferation, apoptosis, cytotoxicity,...
Introduction: Diabetic wounds are challenging to treat due a wide range of pathophysiological changes. Hypoxia is one the predominant contributing factors poor vascularization and chronicity in diabetic wounds. This study was designed develop polycaprolactone (PCL)-based oxygen-releasing electrospun wound dressings evaluate their efficacy for improved full thickness healing rats. Methods: PCL-based oxygen releasing were made using electrospinning technology. The developed characterized terms...
Use of medicinal plants for the biosynthesis nanoparticles offers several advantages over other synthesis approaches. Plants contain a variety bioactive compounds that can participate in reduction and capping nanoparticles. Plant mediated has leverage cost effectiveness, eco-friendly approach sustained availability. In current study Silybum marianum, medicinally valuable plant rich silymarin content, is used as reducing stabilizing agent fabrication Biosynthesized CuO-NPs were characterized...
Nanotechnology is an emerging area of research that deals with the production, manipulation, and application nanoscale materials. Bio-assisted synthesis particular interest nowadays, to overcome limitations associated physical chemical means. The aim this study was synthesize ZnO nanoparticles (NPs) for first time, utilizing seed extract Lepidium sativum. synthesized NPs were confirmed through various spectroscopy imagining techniques, such as XRD, FTIR, HPLC, SEM. characterized then...
Abstract Introduction Mesenchymal stem cells (MSCs) have the potential for treatment of diabetic cardiomyopathy; however, repair capability MSCs declines with age and disease. from animals exhibit impaired survival, proliferation, differentiation therefore require a strategy to improve their function. The aim study was develop preconditioning augment ability diabetes patients heart. Methods Diabetes induced in C57BL/6 mice (6 8 weeks) streptozotocin injections (55 mg/kg) 5 consecutive days....
Ischemia is the major cause of acute kidney injury (AKI), associated with high mortality and morbidity. Mesenchymal stem cells (MSCs) have multilineage differentiation potential can be a potent therapeutic option for cure AKI. MSCs were cultured in four groups SNAP (S-nitroso N-acetyl penicillamine), + Methylene Blue (MB), MB control vitro analysis. Cultured pre-conditioned either (100 μM) or (1 both 6 hours. Renal ischemia was induced (as study) rats by clamping left renal padicle 45...
Abstract Diabetes is a complex metabolic disorder and different environmental toxicants including heavy metals have been involved in diabetes induction. Therefore, assessment of the risk factors induced toxicity become critical for reducing consequences pollutants. Previously, we reported nephrotoxicity non-diabetic diabetic rats. Here, extended our analysis by examining organs (heart, kidney, liver, pancreas, spleen) damage Wistar rats using histopathology quantitative real-time PCR...
Following recent findings from our group that curcumin preconditioning augments the therapeutic efficacy of adipose-derived stem cells in healing diabetic wounds rats, we aimed to investigate regenerative effects preconditioned mesenchymal (ASCs) for better recovery acid inflicted burns this study.ASCs were with 5 μM 24 hours and assessed proliferation, migration, paracrine release potential gene expression comparative naïve ASCs. Subsequently, capacity ASCs (Cur-ASCs) versus was examined...
Stimuli-responsive drug delivery systems are urgently required for injectable site-specific and release of drugs in a controlled manner. For this purpose, we developed novel pH-sensitive, biodegradable, antimicrobial hydrogels from bio-macromolecule pectin, polyvinylpyrrolidone (PVP), 3-aminopropyl (diethoxy)methyl silane (3-APDEMS), sepiolite clay via blending solution casting technique. The purified (40 um) was functionalized with 3-APDEMS crosslinker ( ex-situ modification) followed by...
Abstract Burns are potentially fatal and physically debilitating injuries, causing psychological physical scars result in chronic disabilities. A well vascularized wound bed is required to achieve complete scar free closure. For many centuries, a variety of herbal plants have been used for healing, among these aloe vera (AV) has found be very effective healing. Secondly, the main reason delayed healing bacterial infections. Ofloxacin (OX) reported as an active antibacterial drug topical...
The therapeutic effectiveness of stem cells after transplantation is hampered by the hypoxic milieu chronic wounds. Prior research has established antioxidant priming as a thorough plan to improve cell performance. purpose this study was ascertain how caffeic acid (CA) affected ability human adipose-derived (hASCs) function under stress. In order cytoprotective properties CA, hASCs were primed with CA in CoCl