A5000442029- Mesenchymal stem cell research
- Osteoarthritis Treatment and Mechanisms
- Liver physiology and pathology
- Wound Healing and Treatments
- Hearing, Cochlea, Tinnitus, Genetics
- Bioactive Compounds in Plants
- Liver Disease Diagnosis and Treatment
- Diabetic Foot Ulcer Assessment and Management
- Drug-Induced Hepatotoxicity and Protection
- Hydrogels: synthesis, properties, applications
- Bioactive Natural Diterpenoids Research
- Biochemical Acid Research Studies
- Phytochemistry and Bioactivity Studies
- Enzyme Production and Characterization
- Connexins and lens biology
- Advanced Drug Delivery Systems
- Silk-based biomaterials and applications
- Circular RNAs in diseases
- Medicinal Plants and Bioactive Compounds
- MicroRNA in disease regulation
- Adipose Tissue and Metabolism
- Gynecological conditions and treatments
- Phytochemicals and Antioxidant Activities
- Psidium guajava Extracts and Applications
- Corneal Surgery and Treatments
University of the Punjab
2013-2024
Centre of Excellence in Molecular Biology
2012-2024
Oxidative stress is a major obstacle against cartilage repair in osteoarthritis (OA). Anti-oxidant agents can play vital role addressing this issue. We evaluated the effect of Vitamin E preconditioning improving potential mesenchymal stem cells (MSCs) to confer resistance oxidative prevailing during OA.Vitamin pretreated MSCs were exposed vitro by hydrogen peroxide (H2O2) and also implanted surgically-induced rat model OA. Analysis was done terms cell proliferation, apoptosis, cytotoxicity,...
Transplantation of mesenchymal stem cells (MSCs) or autologous chondrocytes has been shown to repair damages articular cartilage due osteoarthritis (OA). However, survival transplanted is considerably reduced in the osteoarthritic environment and it affects successful outcome transplantation cells. Differentiated chrondroytes derived from adipose have proposed as an alternative source our study investigated this possibility rats. We regenerative potential ADSCs DCs found that maintained...
Abstract Pectin/polyacrylic acid (PPAA) hydrogel is a unique and versatile biomaterial with applications in drug delivery, wound healing, tissue engineering, agriculture, owing to its tailored properties multifunctional attributes. This study aims harness the therapeutic potential of Strobilanthes urticifolia extract within PPAA matrix attenuate liver kidney fibrosis through targeted sustained delivery biologically active substances. was prepared by free radical polymerization, followed...
Mesenchymal stem cells (MSCs) are being used to treat many diseases as they exhibit great regenerative potential. However, MSC's transplantation sometimes does not yield the maximum outcome unable survive in inflammatory conditions. Several approaches including preconditioning improve survival rate of mesenchymal cells. One such recently reported approach is MSCs with plant extracts. The present study was designed evaluate effect
Inflammatory microenvironment after transplantation affects the proliferation and causes senescence of adipose-derived mesenchymal stem cells (hADMSCs) thus compromising their clinical efficacy. Priming with herbal extracts is considered very promising to improve viability in inflammatory milieu. Aesculus indica (A. indica) used treat many diseases Asia for decades. Herein, we explored protective role A. extract on human Mesenchymal Stem Cells against Monosodium Iodoacetate (MIA) induced...
Aim: The aim of the present study is to use human amniotic membrane (HAM) for in vitro chondrogenesis placenta-derived mesenchymal stem cells (MSCs) and umbilical cord-derived MSCs. Materials & methods: MSCs from placenta cord were isolated, characterized by immunophenotyping after analyzing their rate proliferation, cytotoxicity viability, was performed on plastic adherent surface HAM. Results: Successfully isolated revealed positive expression markers CD90, CD73, CD105 CD49d, while they...
Epigallocatechin gallate is a polyphenol of tea plants. Other than its trace amounts are found in apple skin, onions and plums. It has anti-adipogenic anti-oxidant potential. was investigated that epigallocatechin stopped the adipogenic differentiation mice mesenchymal stem cells but underlying mechanism not well understood. Different proteins transcription factors responsible for adipocytes could be targets. This study designed to determine potential target human. Human Peroxisome...
Osteoarthritis is characterized by the progressive deterioration of articular cartilage, leading to joint pain and functional impairments. Current treatment options are limited in their ability stimulate cartilage regeneration. Evidence suggests that co-culture technique, involving interplay multiple cell types, may effectively restore damaged cartilage. This investigation assessed regenerative impact on osteoarthritis-affected rat knee joints. Gene expression profiling validated phenotypic...
Liver fibrosis is a natural process that initiates after liver injury to repair the damaged tissue. The has significant capacity for self-repair of To great extent, miscellaneous interactions immune cell subtypes manage these procedures like and wound healing. Objectives: assess hepatoprotective anti-inflammatory potential Euphorbia pilulifera through modulating NF-KB/Nrf2/AKT/TGF-β1 pathway. Methods: methanolic extract was primarily assessed its cytotoxic against HepG2 cells. Methanolic E....
Stress is a state of threatened homeostasis that causes the body to release hormone cortisol produced by adrenal glands.Oviductus ranae (OR) an animal based raw material folk medicine which plays variety activities.However, its anti-stress effects mechanism has not been fully revealed.In this work, on network pharmacology, potential targets OR were screened, and protein-protein interaction (PPI) between target was constructed using STRING database.Kyoto Encyclopedia Genes Genomes (KEGG) used...
Abnormal uterine bleeding (AUB) is from corpus , abnormal in volume, regularity, or timing.
 Objective: To compare the efficacy terms of adequate endometrial sample received by pathologist manual vacuum aspiration versus dilation & curettage females presenting with bleeding.
 Methods: It was a Randomized Controlled Trial performed Department Obstetrics Gynecology, Lahore General Hospital, for one year (April 3, 2020 till april 2, 2021). 390 were randomly divided two groups...
Oxidative stress is a destructive phenomenon that affects various cell structures including membranes, proteins, lipoproteins, lipids, and DNA. inflammation owing to lifestyle changes may lead serious diseases such as Cancers, Gout, Arthritis etc. These disorders can be prevented using different therapeutic strategies nanomedicine. Biosynthesized gold nanoparticles (GNPs) because of their anti-inflammatory antioxidant bioactivities key player in reversal these ailments. This study was...