Inhibitory interneurons of the olfactory bulb are subjected to permanent adult neurogenesis. Their number is modulated by learning, suggesting that they could play a role in plastic changes bulbar network associated with memory. Adult male C57BL/6 mice were trained an associative task, and we analyzed long-term retention task 5, 30, 90 d post-training. In parallel, assessed fate these newborn cells, mapped their distribution measured functional implication using immediate early gene Zif268....

One major unresolved problem in olfaction research is to relate the percept molecular structure of stimuli. The present study examined this issue and showed for first time a quantitative structure-odor relationship which more structurally complex monomolecular odorant, numerous olfactory notes it evokes. Low-complexity odorants were also rated as aversive, reflecting fact that low complexity may serve warning cue system. Taken together, these findings suggest provides framework explain...

Understanding the physiological mechanisms that limit animal thermal tolerance is crucial in predicting how animals will respond to increasingly severe heat waves. Despite their importance for understanding climate change impacts, these underlying upper limits of are largely unknown. It has been hypothesized fish limited by brain and ultimately caused a global depolarization. In this study, we developed methods measuring (CT max ) larval zebrafish ( Danio rerio with simultaneous recordings...

Abstract Exposure to stress during early life affects subsequent behaviors and increases the vulnerability adult pathologies, a phenomenon that has been well documented in humans rodents. In this study, we introduce chronic unpredictable protocol adapted young zebrafish, which is an increasingly popular vertebrate model neuroscience research. We exposed zebrafish series of intermittent mild stressors from day 10 17 post-fertilization. The stressed fish showed reduced exploration novel...

Odor-driven behaviors such as feeding, mating, and predator avoidance are crucial for animal survival. The neural pathways processing these have been well characterized in a number of species, involve the activity diverse brain regions following stimulation olfactory bulb by specific odors. However, while zebrafish circuitry is understood, comprehensive characterization linking odor-driven to odors needed better relate computations responses.

Gadolinium (Gd) is one of the rare earth elements (REY) and widely used in magnetic resonance imaging (MRI) contrast agents. Anthropogenic Gd enrichment has frequently been found wastewater treatment plant effluents industrialised countries, rising concerns regarding effects on aquatic biota. This study investigates acute toxicity sublethal two forms, as inorganic salt (GdCl3) Gd-based agent (GBCA), early life stages zebrafish (Danio rerio). Nominal exposure concentrations ranged from 3 to...

Sensory neural activity is highly context dependent and shaped by experience expectation. In the olfactory bulb (OB), first cerebral relay of processing, responses to odorants are previous experiences including contextual information thanks strong feedback connections. present experiment, mice were conditioned associate an odorant with a visual then exposed alone. We found that alone elicited exploration odor port similar stimulus when it was initially presented. OB, activation pattern,...

Both passive exposure and active learning through reinforcement enhance fine sensory discrimination abilities. In the olfactory system, this enhancement is thought to occur partially integration of adult-born inhibitory interneurons resulting in a refinement representation overlapping odorants. Here, we identify mice novel unexpected dissociation between at level granule cells. Specifically, while both processes augment neurogenesis, cells differ their morphology, functional coupling thus...

Interhemispheric connections enable interaction and integration of sensory information in bilaterian nervous systems are thought to optimize computations. However, the cellular spatial organization interhemispheric networks computational properties they mediate vertebrates still poorly understood. Thus, it remains unclear what extent connectivity between left right brain hemispheres participates processing. Here, we show that zebrafish olfactory bulbs (OBs) receive direct projections from...

Background It has recently been proposed that adult-born neurons in the olfactory bulb, whose survival is modulated by learning, support long-term memory. However, mechanism used to select which following learning will participate retention of information unknown. We addressed this question investigating effect bulbar consolidation on memory and neurogenesis. Methodology/Principal Findings Initially, we a behavioral ecological approach using adult mice assess impact Using paradigms time was...

We recently reported data showing that, while human olfactory pleasantness is modulated by semantic knowledge of smells, the physicochemical aspects odorant molecules are prominent determinants odor hedonic valence, especially in children and seniors, two age groups characterized either low level (children) or weak access to (seniors) knowledge.1 Here, we present additional from a an animal study, confirming that structure predicts suggesting this influence may be already engraved at receptor level.

Noradrenaline contributes to olfactory-guided behaviors but its role in olfactory learning during adulthood is poorly documented. We investigated implication associative and perceptual using local infusion of mixed α1-β adrenergic receptor antagonist (labetalol) the adult mouse bulb. reported that learning, as opposed was not affected by labetalol infusions Accordingly, this treatment did affect survival bulbar adult-born neurons. Altogether, our results suggest noradrenergic system plays...

We recently reported data showing that, while human olfactory pleasantness is modulated by semantic knowledge of smells, the physicochemical aspects odorant molecules are prominent determinants odor hedonic valence, especially in children and seniors, two age groups characterized either low level (children) or weak access to (seniors) knowledge.1 Here, we present additional from a an animal study, confirming that structure predicts suggesting this influence may be already engraved at receptor level.

Human generated environmental change profoundly affects organisms that reside across diverse ecosystems. Although nervous systems evolved to flexibly sense, respond, and adapt change, it is unclear whether the rapid rate of outpaces adaptive capacity complex systems. Here, we explore neural mediating responses to, or impacted by, changing environments, such as those induced by global heating, sensory pollution, habitation zones. We focus on rising temperature accelerated changes in...

Abstract Behavioral and physiological evidence indicates that odor processing in the main olfactory bulb is influenced by experience. At cellular level, changes inhibitory influence exerted granular interneurons may contribute to restructuring representations. To assess experience‐dependent modulation responsiveness of granule cells, we measured level spatial distribution odor‐induced expression immediate–early gene Zif268 cell layer adult mice submitted or not discrimination conditioning....

ABSTRACT Understanding the physiological mechanisms that limit animal thermal tolerance is crucial in predicting how animals will respond to increasingly severe heatwaves. Despite its importance for understanding climate change impacts, these underlying upper limits of are largely unknown. It has been hypothesised fish limited by brain and it ultimately caused a global depolarization. In this study, we developed methods measuring (CT max ) larval zebrafish ( Danio rerio with simultaneous...

SUMMARY Interhemispheric connections enable interaction and integration of sensory information in bilaterian nervous systems are thought to optimize computations. However, the cellular spatial organization interhemispheric networks as well computational properties they mediate vertebrates still poorly understood. Thus, it remains unclear which extent connectivity between left right brain hemispheres participates processing. Here, we show that zebrafish olfactory bulbs (OBs) receive direct...

ABSTRACT Odor-driven behaviors such as feeding, mating and predator avoidance are crucial for animal survival. While the zebrafish olfactory circuitry is well understood, a comprehensive description of odor-driven needed to better relate computations responses. Here, we used medium-throughput setup measure swimming trajectories 10 in response 17 ecologically relevant odors. By selecting appropriate locomotor metrics, constructed ethograms systematically describing odor-induced changes...