A5028397897- Zebrafish Biomedical Research Applications
- Olfactory and Sensory Function Studies
- Neurobiology and Insect Physiology Research
- Neural dynamics and brain function
- Neuroscience and Neuropharmacology Research
- Genetic and Kidney Cyst Diseases
- Animal Behavior and Reproduction
- Biochemical Analysis and Sensing Techniques
- Protist diversity and phylogeny
- Neonatal and fetal brain pathology
- Memory and Neural Mechanisms
- Neurogenesis and neuroplasticity mechanisms
- Photoreceptor and optogenetics research
- Developmental Biology and Gene Regulation
- Advanced Chemical Sensor Technologies
- Fish Ecology and Management Studies
- Congenital heart defects research
- Hemispheric Asymmetry in Neuroscience
- Cerebrospinal fluid and hydrocephalus
- Insect Utilization and Effects
- Fetal and Pediatric Neurological Disorders
- Neuroendocrine regulation and behavior
- Neuroethics, Human Enhancement, Biomedical Innovations
- Ion Channels and Receptors
- Invertebrate Immune Response Mechanisms
Norwegian University of Science and Technology
2015-2025
Koç University
2022-2025
KU Leuven
2013-2021
Neuroelectronics Research Flanders
2011-2021
Kavli Institute for Systems Neuroscience
2016-2021
St Olav's University Hospital
2019
Norwegian Environment Agency
2017
FENS Kavli Network of Excellence
2016
VIB-KU Leuven Center for Microbiology
2013-2015
Vlaams Instituut voor Biotechnologie
2014
Yeast cells produce various volatile metabolites that are key contributors to the pleasing fruity and flowery aroma of fermented beverages. Several these metabolites, including isoamyl acetate ethyl acetate, produced by a dedicated enzyme, alcohol acetyl transferase Atf1. However, despite much research, physiological role ester formation in yeast remains unknown. Using combination molecular biology, neurobiology, behavioral tests, we demonstrate deletion ATF1 alters olfactory response...
Motile cilia are miniature, propeller-like extensions, emanating from many cell types across the body. Their coordinated beating generates a directional fluid flow, which is essential for various biological processes, respiration to reproduction. In nervous system, ependymal cells extend their motile into brain ventricles and contribute cerebrospinal (CSF) flow. Although not only contributors CSF functioning crucial, as patients with defects develop clinical features, like hydrocephalus...
Left-right asymmetries are most likely a universal feature of bilaterian nervous systems and may serve to increase neural capacity by specializing equivalent structures on left right sides for distinct roles [1Concha M.L. Bianco I.H. Wilson S.W. Encoding asymmetry within circuits.Nat. Rev. Neurosci. 2012; 13: 832-843Crossref PubMed Scopus (95) Google Scholar]. However, little is known about how encoded vertebrate circuits lateralization influences processing information in the brain....
Abstract Brain activity and connectivity alter drastically during epileptic seizures. The brain networks shift from a balanced resting state to hyperactive hypersynchronous state. It is, however, less clear which mechanisms underlie the transitions. By studying neural glial in zebrafish models of seizures, we observe striking differences between these networks. During preictal period, neurons display small increase synchronous only locally, while gap-junction-coupled network was highly...
Fear conditioning is a form of learning essential for animal survival and used as behavioral paradigm to study the mechanisms memory. In mammals, amygdala plays crucial role in fear conditioning. teleost, medial zone dorsal telencephalon (Dm) has been postulated be homolog mammalian by anatomical ablation studies, showing conditioned avoidance response. However, neuronal populations required response via Dm have not functionally or genetically defined. We aimed identify population through...
Detecting pathogens and mounting immune responses upon infection is crucial for animal health. However, these come at a high metabolic price (McKean Lazzaro, 2011, Kominsky et al., 2010), avoiding before may be advantageous. The bacterial endotoxins lipopolysaccharides (LPS) are important system cues (Abbas 2014), but it remains unknown whether animals possess sensory mechanisms to detect them prior infection. Here we show that Drosophila melanogaster display strong aversive LPS gustatory...
Motile cilia defects impair cerebrospinal fluid (CSF) flow and can cause brain spine disorders. The development of ciliated cells, their impact on CSF flow, function in axial morphogenesis are not fully understood. We have characterized motile cells within the zebrafish ventricles. show that ventricles undergo restructuring through development, involving a transition from mono- to multiciliated (MCCs) driven by gmnc. MCCs co-exist with monociliated generate directional patterns. These...
In vertebrates, olfactory receptors localize on multiple cilia elaborated dendritic knobs of sensory neurons (OSNs). Although dysfunction can cause anosmia, how their differentiation is programmed at the transcriptional level has remained largely unexplored. We discovered in zebrafish and mice that Foxj1, a forkhead domain-containing transcription factor traditionally linked with motile biogenesis, expressed OSNs required for epithelium (OE) formation. keeping immotile nature cilia, we...
Components of odor mixtures often are not perceived individually, suggesting that neural representations simple combinations the components. We studied responses to binary amino acids and food extracts at different processing stages in olfactory bulb (OB) zebrafish. Odor-evoked input OB was measured by imaging Ca 2+ signals afferents glomeruli. Activity patterns evoked were predictable within narrow limits from component patterns, indicating mixture interactions peripheral system weak....
Astroglial excitatory amino acid transporter 2 (EAAT2, GLT-1, and SLC1A2) regulates the duration extent of neuronal excitation by removing glutamate from synaptic cleft. Hence, an impairment in EAAT2 function could lead to imbalanced brain network excitability. Here, we investigated functional alterations astroglial networks associated with loss astroglia predominant eaat2a gene zebrafish. We observed that eaat2a-/- mutant zebrafish larvae display recurrent spontaneous light-induced seizures...
Odors are initially represented in the olfactory bulb (OB) by patterns of sensory input across array glomeruli. Although activated glomeruli often widely distributed, responding to stimuli sharing molecular features tend be loosely clustered and thus establish a fractured chemotopic map. Neuronal circuits OB transform glomerular into spatiotemporal output activity thereby extract information about stimulus. It is, however, unknown whether spatial organization inputs is maintained during...